Navigation Links
Statins May Boost Diabetes Risk in Older Women
Date:1/9/2012

By Kathleen Doheny
HealthDay Reporter

MONDAY, Jan. 9 (HealthDay News) -- Statin medications used by women after menopause appear to increase their risk of developing diabetes, according to a large, new study.

The research echoes findings of other studies linking the cholesterol-lowering drugs with an increased diabetes risk in men and women. Statins include drugs such as Lipitor, Lescol and Mevacor.

"We found statins increased the risk of diabetes about 48 percent after adjusting for different risk factors such as family history of diabetes, body mass index and [physical] activity," said Dr. Yunsheng Ma, associate professor of medicine and an epidemiologist at the University of Massachusetts Medical School in Worcester, Mass. "It's a moderate risk," he said.

However, the study found an association, not a cause and effect.

The authors stressed that the findings -- published online Jan. 9 in the Archives of Internal Medicine -- are not a reason to change current guidelines for use of the drugs in those with or without diabetes. Statins are often prescribed to lower blood cholesterol levels in order to prevent heart disease or its progression. Diabetes is a strong risk factor for heart disease.

For the study, the researchers followed nearly 154,000 participants in the Women's Health Initiative, a long-running look at health issues in postmenopausal women.

At the study start in 1993, their average age was 63, and slightly more than 7 percent were taking statins. By 2005, more than 10,200 reported they had developed type 2 diabetes, meaning their blood sugar levels were too high.

People with type 2 diabetes don't make or properly utilize insulin, a hormone that regulates the amount of sugar, or glucose, in the blood. Uncontrolled diabetes can damage the kidneys, nerves and eyes.

Those taking statins were more likely to develop diabetes, the researchers found. When contributing factors such as family history and excess weight were considered, the statin users were nearly 1.5 times more likely to develop diabetes than those not taking statins. The risk applied for all kinds of statin drugs.

The researchers can't explain the link. "It's still an area under scrutiny," said Annie Culver, the study's first author and a consulting pharmacist with the University of Massachusetts Medical School.

"Statins may affect the way the body manages insulin and glucose responses," she said.

The take-home message for women and others, the researchers said, is to pay attention to lifestyle measures that can lower diabetes risk or help manage the disorder if they already have it. Keeping a healthy body weight, eating a healthy diet and getting regular physical activity can all help.

"If they do need statin therapy, they should not be complacent that medication will solve the problem," Culver said. Lifestyle measures still matter, she added.

If an older woman needs statins to reduce heart attack or stroke risk, this study should not dissuade them, agreed Dr. Spyros Mezitis, a clinical endocrinologist consultant at Lenox Hill Hospital in New York City. He said the findings are observational, and as such the researchers cannot control for all the possible confounding factors.

Doctors should try to keep statin dosage as low as possible, he said. And women with and without diabetes who are prescribed a statin to lower cholesterol should expect regular monitoring of their cholesterol and blood glucose levels.

Dr. Suzanne Steinbaum, attending cardiologist and director of Women and Heart Disease at the Heart and Vascular Institute at Lenox Hill Hospital, said that as a result of the findings, women on the medications should watch their intake of sugar, starches and carbohydrates to maintain healthy blood sugar levels.

Every woman taking a statin needs to know her risk of heart disease, Steinbaum said, and she needs to ask her doctor, "Is the statin necessary?"

The researchers, who noted that statins can manage the heart-related consequences of diabetes, said more work is needed to unravel the link between the drugs and the blood-sugar disorder.

More information

To learn more about statins and cholesterol, visit the U.S. Food and Drug Administration.

SOURCES: Yunsheng Ma, M.D., Ph.D., associate professor of medicine and epidemiologist, University of Massachusetts Medical School, Worcester, Mass.; Annie Culver, B.Pharm., consulting pharmacist, University of Massachusetts Medical School, Worcester, Mass.; Spyros Mezitis, M.D., Ph.D., endocrinologist and clinical endocrinology consultant, Lenox Hill Hospital, New York City, and assistant professor, clinical medicine, New York Presbyterian Hospital-Cornell Medical Center; Suzanne Steinbaum, D.O., attending cardiologist and director, Women and Heart Disease, Heart and Vascular Institute, Lenox Hill Hospital, New York City; Jan. 9, 2012, Archives of Internal Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Statins may increase risk of interstitial lung abnormalities in smokers
2. Could Statins Help Those Hospitalized With Flu?
3. Statins may reduce mortality in patients hospitalized with influenza
4. High Doses of Statins Tied to Less Arterial Plaque in Study
5. Statins Dont Raise Risk of Brain Bleeds After Stroke: Study
6. Statins reduce deaths from infection and respiratory illness, 8 years on from trial
7. Statins May Help Heart in Some Young Stroke Patients
8. Statins Dont Seem to Raise Cancer Risk
9. High-Dose Statins May Increase Diabetes Risk
10. Statins may protect against kidney complications following elective surgery
11. Statins make radiation more effective at curing prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins May  Boost Diabetes Risk in Older Women
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, ... ... has partnered with Mediaplanet to help educate the many who are unaware of ... section dedicated to aphasia will run within the “Stroke Awareness” campaign. , The ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... students studying complementary medicine. Allison Outerbridge is this year’s Life University ... May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching ...
(Date:5/26/2016)... ... ... W.S. Badger Co. Inc ., the maker of certified organic and ... Award for its use of effective workplace strategies to increase business and employee success. ... the Families and Work Institute (FWI) and the Society for Human Resource Management (SHRM), ...
(Date:5/26/2016)... ... , ... Connor Sports, through its Connor Cares initiative, will continue ... Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and ... forms and levels of the game, Connor Sports has committed to a significantly increased ...
(Date:5/26/2016)... ... ... There are nearly 14.5 million people living with and beyond cancer in ... 5, 2016, communities around the world will gather to recognize these cancer survivors as ... Day® is an annual worldwide Celebration of Life that is held on the first ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... , May 25, 2016  Granger Diagnostics today announced ... for wounds and infections. This test ensures discovery ... select viruses. The test requires only a simple swab ... David G. Bostwick , MD, Chief ... facilitate wound healing: "We are excited to make ...
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: