Navigation Links
Statins Before Vascular Surgery Cut Deaths, Complications
Date:9/2/2009

Problems halved in patients getting blood-vessel repairs done, study finds

WEDNESDAY, Sept. 2 (HealthDay News) -- A dose of a cholesterol-lowering statin before vascular surgery reduces the risk of complications and death, new Dutch research shows.

The study of nearly 500 patients who had surgery for a variety of blood-vessel problems found the incidence of heart artery blockage and deaths was halved in those who received an 80-milligram dose of fluvastatin before their operation, compared to those given a placebo.

"The manuscript showed that fluvastatin extended-release is safe in the perioperative period, associated with a reduced inflammatory status and improved outcome, compared to placebo," said Dr. Don Poldermans, a professor of internal medicine at Erasmus Medical Center in Rotterdam, the Netherlands, and a principal author of a report in the Sept. 3 issue of the New England Journal of Medicine.

Heart artery blockage occurred in 10.8 percent of the people who received fluvastatin and 19 percent of those who were given a placebo, the report said. Deaths from heart attacks or other cardiovascular problems occurred in 4.8 percent of those who received fluvastatin and 10.1 percent of those given placebo.

Fluvastatin is available in generic form in the United States, sold as Lescol, Canef and other brand names. Other statins include Crestor, Lipitor and Zocor.

The new study confirms the growing idea that statin therapy is a valuable tool in blood-vessel surgery, American experts said.

"This study confirms a lot of previous work," said Dr. Bruce A. Perler, chief of vascular surgery at Johns Hopkins Medical Institutions, in Baltimore. "Much of that work comes from small, retrospective studies. This is a well-done, placebo-controlled trial that confirms what we have suspected for a long time."

Perler led one previous study that compared the outcome of surgery on the carotid artery, the main artery to the brain, in people who had or had not been taking a statin before the operation. "We showed in our study a significantly lower incidence of 30-day stroke and 30-day deaths [with statin treatment]," Perler said.

That study did not distinguish between the various statins being used, but "there is no reason to believe that this isn't a class effect," said Dr. Louis E. Teichholz, medical director of the division of cardiology at Hackensack University Medical Center, in New Jersey. "No matter which statin you give, there is no major difference over another statin."

The major reason for the benefit in surgery probably is not the cholesterol-lowering effects of statins, Perler and Teichholz noted, because the benefit was seen in people who did not have high cholesterol.

The drugs also reduce inflammation, and the Dutch study found marked reductions in markers of inflammation in those given a statin, Teichholz said.

"Statins also have major anti-thrombotic [clot-preventing] effects and are antioxidants," Perler said.

There are no current guidelines recommending use of statins before vascular surgery, but the concept seems to be taking hold in clinical practice, Teichholz noted. "It appears to be what we should be doing, barring contraindications," he said. "There are no official guidelines but, based on this and other studies, it would be prudent to consider statins in patients with vascular disease."

Statins can cause acute muscle pain in a minority of people, and they can be dangerous in people with poor liver function, but are otherwise safe, Teichholz said.

One practical reason why physicians might not prescribe a statin before vascular surgery is that so many people already are taking them, Perler said. "In my practice, it is very unusual to see patients who are not on statins," he added.

More information

Statins and other cholesterol-lowering drugs are described by the American Heart Association.



SOURCES: Don Poldermans, M.D., professor, internal medicine, Erasmus Medical Center, Rotterdam, the Netherlands; Bruce A. Perler, M.D., chief, vascular surgery, Johns Hopkins Medical Institutions, Baltimore; Louis E. Teichholz, M.D., director, division of cardiology, Hackensack University Medical Center, Hackensack, N.J.; Sept. 3, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stopping Statins After Stroke Doubles Death Risk
2. Research to shed new light on how statins benefit heart patients
3. Statins reduce loss of function, keeping old lungs young - even in smokers
4. Better Prostate Cancer Survival for Men Taking Statins
5. Statins After Bypass Lower Stroke Risk
6. Latest Study Says Statins Dont Slow Alzheimers
7. New Gene-Based Therapy an Alternative to Vytorin and Statins in Heart Disease Prevention and Treatment
8. Tendon complications, though rare, linked to statins
9. Cholesterol-Lowering Statins Tied to Tendon Woes
10. Women are treated less frequently than men with statins, aspirin and beta-blockers
11. iGuard.org Presents New Data on Statins at FDA Workshop Demonstrating How Patient-Reported Information Can Enhance Drug Safety Knowledge
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins Before Vascular Surgery Cut Deaths, Complications
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... a number of ,world firsts,: , TwinLink™ ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Surgical Procedure Volumes: Global Analysis (United States, China, Japan, ... report to their offering. ... tool for healthcare business planners, provides surgical procedure volume ... surgery trends with an in-depth analysis of growth drivers ...
(Date:6/23/2016)... -- The National Pharmaceutical Council (NPC) today announced that ... organization as its newest member.  ... and chief scientific officer, Mallinckrodt Pharmaceuticals, will serve ... of Directors. ... in support of our efforts to conduct research ...
Breaking Medicine Technology: