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Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein
Date:11/11/2008

than or equal to 10 percent and half >10 percent (10 percent to 20 percent indicates an intermediate risk level). While they had not had any cardiovascular event, those with a FRS >10 would be considered to be at higher risk for such events than a low risk or completely healthy population. More than 89,000 patients were screened to find the 17,802 who participated. Most of those excluded had either LDL levels that were too high or hsCRP levels that were too low.

Overall, compared to placebo-treated participants in the trial, those given rosuvastatin had a 44 percent reduction in the primary endpoint of a first major cardiovascular event -- a composite of heart attack, stroke, revascularization, hospitalization for unstable angina and cardiovascular death. Hospitalizations for cardiac reasons were also reduced and the authors suggested that the strategy tested in JUPITER of treating elevated hsCRP patients with statin therapy could be cost-effective.

Ridker said one particularly striking finding was a 37 percent reduction in first events in men and women in the statin group who had no other risk factors except for elevated hsCRP, a sign of inflammation that can be associated with increased coronary disease risk.

The researchers found no increase in the number of patients with either muscle pain or cancer among those given rosuvastatin. As in almost all prior statin trials, they observed a small increase in reported diabetes, said Ridker, the Eugene Braunwald Professor of Medicine at Harvard Medical School.

The very low LDL levels produced by rosuvastatin (median 54 at 24 months) raise the question of whether other adverse effects might be seen over a longer time period, but they were not evident here.

Low-density lipoprotein (LDL) is a component of total cholesterol thought to contribute to plaque buildups that narrow arteries, a process called atherosclerosis. JUPITER participants had average LDL levels of 108 milligrams per decil
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SOURCE American Heart Association
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