Navigation Links
Statin Alternative Looks Promising in Early Trials
Date:3/21/2012

which include liver damage or muscle pain -- and others don't achieve the recommended LDL blood levels of 70 milligrams (mg) per deciliter or lower for those at risk of heart disease.

Two randomized, single-dose studies of the antibody, known as REGN727, were administered either intravenously (in 40 participants) or by injection (in 32 participants) and compared with a group given an inactive placebo. These trials were followed by a randomized study of multiple doses in 51 adults with high cholesterol who were taking atorvastatin (brand name Lipitor) and whose baseline LDL levels were more than 100 mg per deciliter.

Higher doses of REGN727 lowered LDL cholesterol levels by up to 64 percent, and the effect was similar across the board whether or not participants were also taking a statin, which works by a different mechanism.

Commenting on the study, Christine Metz, head of the Laboratory of Medicinal Biochemistry at the Feinstein Institute for Medical Research in Manhasset, N.Y., said, "The next step would be to test a much larger group of people for a much longer time. But this is very promising, apparently safe under the conditions used, and worth very quickly going forward."

Garratt noted that the new drug, which could take at least several years to reach the market, would need to be injected, since antibodies typically can't be formulated into pills. Such a compound would likely be extremely expensive, especially when compared to statins, which are now available as generic drugs. Also, like statins, such a drug would probably need to be taken for life, he said.

Metz pointed out that the trials were very small and consisted heavily of men, making it hard to generalize results for a broader population.

However, "I thought the study was very beautifully conceived and well done," she added. "It did everything it set out to do."

More information

The U.S. National Library of Medicine has
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Small Increase in Diabetes Risk Noted in Statin Patients
2. Statins May Benefit Prostate Cancer Patients
3. Alternative to Statins Shows Promise
4. Statins may slow progression of multiple sclerosis, new study finds
5. Statins May Slow Progression of Multiple Sclerosis, New Study Finds
6. Do Statins Lower Male Sex Drive?
7. Statins Wont Lower Colon Cancer Risk
8. Statins decrease risk of clot-related diseases
9. Statin Use Tied to Eye, Kidney, Liver Troubles
10. Some statins have unintended effects and warrant closer monitoring, study finds
11. Too Many Stroke Patients Go Without Statins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statin Alternative Looks Promising in Early Trials
(Date:7/13/2014)... Albany, New York (PRWEB) July 13, 2014 ... Share, Growth, Trends and Forecast 2013 - 2019 , ... the patients suffering from myopia or cataracts. The lenses ... crystalline. After the cataract surgery intraocular lens replaces the ... (PIOL) switches with original crystalline lens to deliver the ...
(Date:7/13/2014)... inexpensive, portable, microchip-based test for diagnosing type-1 diabetes ... better understand the disease, according to the device,s ... , Described in a paper to be published ... the test employs nanotechnology to detect type-1 diabetes ... the two main forms of diabetes mellitus, which ...
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, ... Additionally, the company’s chief executive officer has announced a new ... are offered at discounted prices, from 15 to 26 percent ... are in huge demand in the current market. We are ... have a lot of high quality products for sale. Many ...
(Date:7/13/2014)... 13, 2014 The North American water storage ... 2013 to $5,450 million by 2018, at a CAGR of ... is expanding at a rapid pace in North America. The ... laws on water & wastewater storage and collection, and the ... market is expanding at a healthy rate in Canada, and ...
(Date:7/13/2014)... July 13, 2014 The report ... Molybdenum, Iron), Form (Chelated & Non Chelated), Application ... - Global Trends and Forecast to 2018” defines ... an analysis and forecasting of the global value ... the driving and restraining factors for the global ...
Breaking Medicine News(10 mins):Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4
... social growth might also see growing waistlines among their ... University and the University of Colorado. The ... improve conditions such as malnutrition and infectious disease, it ... "It,s a troubling finding," said Rice sociology ...
... from the NCAA will kick off a groundbreaking, long-term ... led by University of Michigan researchers and their colleagues ... to begin to fund a longitudinal study by the ... that includes three founding members from the University of ...
... Storrs HealthDay Reporter , TUESDAY, March 13 (HealthDay ... do with factors like race, age and where they live, ... to a new study. Researchers analyzed food questionnaires from ... and older in the continental United States, with a focus ...
... March 11 (HealthDay News) -- High school and college students around ... or sick on vacation can ruin the fun. The American ... take to prevent injuries and stay safe while traveling with their ... a person should go to the nearest ER so we can ...
... Madonna Behen HealthDay Reporter , THURSDAY, March 8 ... can take years off your life, but a new Israeli ... mid-80s, carrying some extra pounds might actually help you live ... that while obesity did increase the risk of dying for ...
... March 8, 2012 Research published today in the ... Ludwig Institute for Cancer Research (LICR) and Memorial Sloan-Kettering Cancer ... (ipilimumab), fostered a strong immune response and a favorable clinical ... of skin cancer. The size of both the tumor ...
Cached Medicine News:Health News:Economic and social growth of developing nations may increase obesity 2Health News:Groundbreaking, long-term study of head injuries among athletes kicks off with NCAA grant 2Health News:Groundbreaking, long-term study of head injuries among athletes kicks off with NCAA grant 3Health News:Race, Location Big Factors in American Diets 2Health News:Race, Location Big Factors in American Diets 3Health News:Spring Break Safety Tips to Keep Vacation Fun 2Health News:Could Fat Be Your Friend Over Age 85? 2Health News:Could Fat Be Your Friend Over Age 85? 3Health News:NEJM study shows combination treatments benefit melanoma patient 2
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
(Date:7/10/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), a ... entered into an agreement with Merck KGaA, Darmstadt, ... in the United States and ... KGaA,s biopharmaceutical division on the development and commercialization of ... Ventana,s proprietary diagnostic assays. In alignment with Merck KGaA,s ...
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Sept. 21 As consumer healthcare expenses rise, ... customer satisfaction has increased considerably from 2009, according ... National Pharmacy Study(SM) released today. ... http://www.newscom.com/cgi-bin/prnh/20050527/LAF028LOGO-a ) The study, now in ...
... 21 HealthWarehouse.com, Inc. (OTC Bulletin Board: ... Columbia Medical Associates, an outpatient clinic system offering medical ... partnership to offer patients a 30-day supply of more ... home delivery. Columbia Medical Associate,s "Columbia Care" ...
Cached Medicine Technology:J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 2J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 3J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 4J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 5HealthWarehouse.com Partners with Columbia Medical Associates to Bring Affordable Healthcare to Washington State 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: