Navigation Links
Starving inflammatory immune cells slows damage caused by multiple sclerosis
Date:9/1/2011

In a paper published today in the journal Scientific Reports, a pair of researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences report that inhibiting the ability of immune cells to use fatty acids as fuel measurably slows disease progression in a mouse model of multiple sclerosis (MS).

MS is an autoimmune disease resulting from damage to the myelin sheath, a protective layer surrounding nerve cells. When the sheath is damaged, nerve impulses are slowed or halted, resulting in progressive physical and neurological disabilities. The cause of the damage is inflammation occurring when the body's immune cells attack the central nervous system (CNS).

Marianne Manchester, PhD, professor of pharmacy and first author Leah P. Shriver, PhD, looked at how immune cells in the CNS oxidize fatty acids for energy when their preferred fuel source glucose is in short supply, which may occur in inflamed tissues. In a mouse model mimicking chronic MS, Manchester and Shriver discovered that by inhibiting a single enzyme that helps immune cells effectively exploit fatty acids, the cells eventually starved and died, preventing further inflammatory damage.

Currently, no approved drug or therapy for MS targets fatty acid metabolism. And the specificity of the target inhibiting a single enzyme suggests that adverse side effects associated with existing treatments, such as increased infection risk, is unlikely.

"We expect that because immune cells not in lesions in the CNS are able to use available glucose, they will function just fine during infection and that inhibition of this pathway would not produce general immune suppression," Shriver said.

The enzyme-inhibitor used by Manchester and Shriver in their study is a drug already tested in humans with congestive heart failure, and was generally well-tolerated. The scientists are now using mass spectrometry to determine whether their results in the mouse model are translatable to humans. "We are interested in determining how this pathway is utilized in human tissue samples from MS patients," Manchester said.


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. NIH grant will create behavioral health registry for pediatric inflammatory bowel disease
3. Prozac and Celexa exhibit anti-inflammatory effects
4. Physician's Pain Relief Cream Includes Patented Anti-inflammatory in New Formula
5. Feedback loop explains inflammatory effect on intestinal lining
6. Study Details Machinery of Immune Protection Against Inflammatory Diseases Like Colitis
7. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
8. New research reinforces anti-inflammatory properties of tart cherries
9. First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease
10. POP ROCK BAND Honor Society Drummer Advocates for Inflammatory Bowel Disease Patients on Capitol Hill in Conjunction with World IBD Day
11. Crohn's & Colitis Foundation National Event Helping Women Manage Inflammatory Bowel Disease: Two Women Physician Experts and Researchers in IBD on Interactive Webcast/Teleconference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Starving inflammatory immune cells slows damage caused by multiple sclerosis
(Date:5/4/2016)... ... May 04, 2016 , ... Hight-Doland Insurance Agency’s new community ... up with Big Brothers Big Sisters of Southwest Louisiana to help provide positive mentoring ... . , Big Brothers Big Sisters of Southwest Louisiana has been helping to guide ...
(Date:5/4/2016)... ... May 04, 2016 , ... Dr. Elyson and Dr. Assili, ... surgery at their office. Wisdom tooth removal, a common dental procedure, is performed for ... often are improperly erupted, resulting in risks of complications. By providing wisdom tooth removal ...
(Date:5/4/2016)... ... May 04, 2016 , ... Natalie Jill is a well ... in preparation of the launch of her new book: Natalie Jill’s 7 Day Jump ... guide designed to jump start a new healthy lifestyle featuring simple recipes using MitoXcell’s ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... medical coding, billing and compliance. In upcoming months, AudioEducator has lined up some ... Every conference is designed to give complete compliance know-how and practical, easy-to-apply advice. ...
(Date:5/4/2016)... ... 2016 , ... With the stamp of approval from the United States Congress, ... Cancer Research Month. According to the American Cancer Society (2016) , this year ... in four Americans dying as a result. , With numbers as influential as such, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 2016   Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness ... two patients who tell their personal story and encourage those at risk to get tested ... Hepatitis C ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
(Date:5/3/2016)... , May 3, 2016 Intec ... a clinical-stage biopharmaceutical company, today announced the appointment of ... Regulatory Affairs. "Ms. Strauss-Levy has 15 years ... has established an outstanding track record, having supported the ... regulatory approval processes in the United States ...
(Date:5/2/2016)... , May 2, 2016 Kalorama Information noted ... Medical Records) market in a recent white paper.  The ... Increased physician usage, a growing market are among the ... in Kalorama,s report EMR 2016: The Market ... Kalorama,s seventh complete study of the EMR industry, and ...
Breaking Medicine Technology: