Navigation Links
Starving cancer cells of cholesterol might offer a new way to treat brain tumors
Date:9/15/2011

ival of 15 months after diagnosis. The tumors are difficult to surgically remove because malignant cells invade surrounding brain tissue.

In addition, genetic differences leave some glioblastoma cells in the tumor resistant to chemo- and radiation therapy, the researchers say.

"Some glioblastomas respond well to treatment initially when the therapy-sensitive cells are killed, but the tumor then returns relatively quickly as the therapy-resistant cells proliferate," says co-author Dr. Arnab Chakravarti, chair and professor of Radiation Oncology and co-director of the OSUCCC James Brain Tumor Program.

"Because glioblastomas are among the most treatment-resistant of cancers, new therapeutic strategies are urgently needed," says Chakravarti.

The study used tumor-cell lines, cells from patients and an animal model. Key technical findings include the following:

  • In nearly 50 percent of glioblastomas, a mutation called EGFRvIII hyperactivates the PI3K signaling pathway and a master transcriptional regulator called SREBP-1.

  • Activating this pathway upregulates the low-density lipoprotein (LDL) receptor and promotes LDL uptake, enabling tumor cells to import large amounts of cholesterol that feed tumor-cell growth and survival.

  • Pharmacological activation of the nuclear Liver X Receptor leads to the loss of LDL receptors and to upregulation of the ABCA1 protein pump, which transports cholesterol out of the malignant cells. Together, these actions starve tumor cells of cholesterol, causing their death.

"Because this pathway is activated in other types of cancer, this work may have significant implications for a broad range of cancer types," Mischel says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Starving inflammatory immune cells slows damage caused by multiple sclerosis
2. Enhancing arrest of cell growth to treat cancer in mice
3. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
4. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
5. Low forms of cyclin E reduce breast cancer drugs effectiveness
6. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
7. Soft drinks may increase risk of pancreatic cancer
8. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
9. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
10. Single gene mutation induces endometrial cancer
11. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... 2015 New and more complex ... of manufacturers, payers, pharmacists and patients. Now Specialty ... is partnering with the National Association of Specialty ... solely to this developing field to better equip ... need. , “This partnership creates a powerful platform ...
(Date:4/28/2015)... Celebrating women has become a tradition at ... third year that all things mom and female will be ... is offering some great specials Special discounts ... year could there be to focus on woman," states Marla ... this is a terrific time for it. And the special ...
(Date:4/28/2015)... Louis, Missouri (PRWEB) April 28, 2015 ... report that delves into the reality problem Americans have ... the population will need long-term care services as they ... need such care. , In the report, Carol ... organizations such as the American Health Care Association and ...
(Date:4/28/2015)... April 28, 2015 Once considered an unproven ... have taken the industry by storm with perfectly tailored light ... unit. , More than half of every SuperCloset ... LED , proving the stigma is gone and LED Grow ... positive response from customers and their first hand experience using ...
(Date:4/28/2015)... 28, 2015 The west coast, south, ... the top areas that healthcare professionals searched for jobs ... the month of March 2015. Data was released ... travel nurse jobs , physical therapy jobs , ... and allied health fields. , States with ...
Breaking Medicine News(10 mins):Health News:Specialty Pharmacy Times Partners with National Association of Specialty Pharmacy to Improve Care for Patients 2Health News:Specialty Pharmacy Times Partners with National Association of Specialty Pharmacy to Improve Care for Patients 3Health News:Specialty Pharmacy Times Partners with National Association of Specialty Pharmacy to Improve Care for Patients 4Health News:Commack Massage Therapy and Wellness Day Spa Dedicates Time To Celebrate Women 2Health News:SeniorCare.com Report: America Has a Major Misconception on Aging 2Health News:SuperCloset Reports Surge in KIND LED Grow Light Sales, Saving Indoor Growing Enthusiasts up to 40% on their Power Usage. 2Health News:Hot States for Medical Careers: Healthcare Staffing Agency Aureus Medical Releases Online Search Results 2
... A study published in the July edition of the ... // number and severity of cases of constriction of ... ,Normally constriction of blood vessels occurs ... to strokes and neurological deficits. This can cause not ...
... you away from making an appointment with your// dentists, then ... how you’ve thought before. New advancement in dentistry can cause ... you can get all your dental work done while being ... ,The process of dental sedation is done through sedating ...
... guidance titled "Pharmacogenomic Data Submissions" to speed// development ... pharmacogenomics. ,Pharmacogenomics allows health care providers to ... response and predict the best possible treatment option ... development of targeted therapies like Herceptin for metastatic ...
... the land of mystic magic, serine breath taking beauty, and the ... side of humanity. However there is more to this large ... ,The AIDS virus has been silently threatening all of Asia. Its ... in Asia every day. 1,500 persons effected with the virus die ...
... the health journal Epidemiology has published a major retrospective study ... if there is associated infertility. ,Dr. Louise A. ... team followed 12,193 U.S. women treated for infertility between ... with that of the general population. The women were followed ...
... comet assay has gained rapid importance in detecting various ... have numerous disadvantages and are time consuming, resource intensive ... ,The comet assay attracts adherents by it’s simplicity, speed, ... in-vivo study. The Comet assay can be used to ...
Cached Medicine News:Health News:Clazosentan May help to Improve Blood Circulation after Brain Hemorrhage due to burst Aneurysm 2Health News:Advent of New, More Effective and Personalized Medicines 2Health News:AIDS - The ‘silent but lethal tsunami’ of Asia 2Health News:Detecting DNA Damage With In-Vivo Alkaline Comet Assay 2
(Date:4/28/2015)... 2015  Shares of Celladon Corp. (NASDAQ: CLDN ... the announcement of poor drug trial results of the phase ... agent, MYDICAR.  The selloff may be warranted or it ... bargain basement prices. An analyst report update ... pipeline, financial review, analyst summary, valuation, and recommendation can ...
(Date:4/28/2015)... Israel , April 28, 2015 ... in its sixth funding cycle for U.S.- Israel ... and Energy Efficiency. To be considered, a project ... between a company and a university/research institution (one from the ... proposal should have significant commercial potential and the project outcome ...
(Date:4/27/2015)... Techpool Bio-Pharma Co has experienced tremendous changes in ... chief executive officer, transforming from a traditional private Chinese company ... took office in 2011, he was the senior executive ... and Eisai, with more than 20 years successful management experience ... Asia-Pacific region. "I chose Techpool ...
Breaking Medicine Technology:Examining what's Left after MYDICAR Drug Trial Ends In Failure; Celladon Corp. Analyst Report Issued by BrokerBank Securities, Inc. 2Opportunities for Funding U.S.-Israel Cooperation for Renewable Energy and Efficiency 2Techpool Transforms Into International Player 2Techpool Transforms Into International Player 3
... Nov. 2, 2011 LORENZ customers and business partners have ... Article 57(2) of Regulation (EC) 726/2004 and its impact on ... Interest Group for EVMPD – XEVPRM. One of ... registration are the Requirements of Article 57(2) of Regulation (EC) ...
... GenVec, Inc. (Nasdaq: GNVC ) will report financial ... 9, 2011, before the U.S. financial markets open. The announcement ... 10:00 a.m. EST to discuss the company,s third quarter financial ... the live conference call, please dial 877-558-0567 (U.S. or Canada) ...
Cached Medicine Technology:LORENZ' Response to New EU PV Legislation - Regulation No. 1235/2010 and EVMPD 2GenVec to Release Third Quarter 2011 Financial Results and Conduct a Conference Call on November 9, 2011 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: