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Starting on 3 drugs at time of diagnosis benefits Type 2 diabetics
Date:6/24/2013

many of which were out of the normal range.

  • Patients on triple therapy lost 2-3 pounds on average after two years while patients on conventional therapy gained 9-10 pounds.

  • Fifteen percent of patients on triple therapy experienced one episode of hypoglycemia (low blood glucose), while 46 percent of those on conventional therapy had at least one hypoglycemic event.

    Core deficits corrected

    The triple therapy combines agents that correct two core defects in type 2 diabetes the inability to respond to insulin normally (insulin resistance), and failure of insulin-secreting beta cells to produce enough insulin. Insulin is the hormone that lowers blood glucose levels. Before the study, Dr. DeFronzo and his colleagues, including co-investigator, Muhammad Abdul-Ghani, M.D., Ph.D., of UT Medicine, hypothesized that the triple therapy would produce a greater, more durable reduction in hemoglobin A1c, reduce the fluctuation in plasma glucose by decreasing both fasting and between-meal glucose levels, and prevent weight gain, which is a side effect of traditional therapy.

    Two years of normalcy

    Two years into the three-year study, it is clear that the triple therapy is accomplishing these therapeutic goals, and that beta cells are being preserved and the body is being sensitized to insulin. "These drugs are not cures, but patients are basically normal while taking them," Dr. DeFronzo said. "They are not going to develop the microvascular (blood vessel) complications as long as their blood glucose level remains within the normal range."

    3 drugs, 3 mechanisms

    The triple therapy consists of metformin, a drug that Dr. DeFronzo helped develop in the 1990s; pioglitazone, a newer class of medication for type 2 diabetes; and exenatide, another newer class of drug. Each drug works by a different mechanism, Dr. DeFronzo said. Conventional therapy is to start the patient on metformin and wh
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  • Contact: Will Sansom
    Sansom@uthscsa.edu
    210-567-2579
    University of Texas Health Science Center at San Antonio
    Source:Eurekalert

    Page: 1 2 3

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