Navigation Links
Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
Date:3/31/2010

Scientists have uncovered what could be a very important clue in answering one of the most perplexing questions about cancer: why does it spread to the liver more than any other organ? In a new research report published in the April 2010 issue of Journal of Leukocyte Biology (http://www.jleukbio.org), scientists from New York University describe experimental results suggesting that the immune system may be the reason.

"Our work may open a new field of experimental therapeutics as combating the eventual development of liver metastases by targeting immune suppressive cells in the livers in patients with early cancer can have great benefit," said George Miller, a scientist involved in the work from the Departments of Surgery and Cell Biology at the New York University School of Medicine.

Miller and colleagues reached this conclusion after conducting experiments in mice. In the experiments, the researchers used mice that spontaneously developed pancreatic cancer because of a mutation (Kras-mutation) in the progenitor cells of the pancreas, as well as mice with advanced colon cancers that spread to the abdomen. They then studied the expansion of immune suppressive cells in the liver from a very early stage in the cancer development to determine the immune phenotype, stimulus for recruitment, inhibitory effects and tumor-enabling function of these cells. Results suggest that combating immune suppressive cells in the liver early after cancer development may prevent the spread of cancer to this vital organ.

"This study could represent one of those 'a-ha' moments in science where one idea or experiment opens up entirely new ways of approaching and understanding a problem," said Luis Montaner, Editor-in-Chief of the Journal of Leukocyte Biology. "Physicians have known that the spread of cancer to the liver is far too common to occur by chance. Now we know that the immune system likely plays a role in facilitating this process. The next step, obviously, is to learn more so we can prevent it from happening."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York
2. The Five Best Valentines Day Gifts Youve Never Heard of - Starting Under $20
3. Stopping schizophrenia before it starts?
4. St. Augustine Elks to Start Elks Kids Fit Club
5. All for Haiti: America TeVe Starts a Humanitarian Bridge to Help Earthquake Victims in Haiti
6. Snatched from the Jaws of Retirement: Spiraling Treatment Costs Push Senior To Start Pan American Dental Tours
7. MYA Cosmetic Surgery have an uplifting start in 2010!
8. 2010 Will Be a Great Year for a Change! Start a New Career Now!
9. LogoLoft.com Posts 64% Sales Increase Over Previous Year As More Americans Start Their Own Businesses
10. Golden Living Kick-Starts Post-Acute Health IT with Microsoft HealthVault and Amalga UIS Connection
11. Request A Test Receives Weatherhead 100 Upstart Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/19/2017)...   ZirMed Inc ., a recognized leader in cloud-based ... has been ranked #1 by its users for the seventh ... User Survey. ZirMed was recognized as the top-ranked end-to-end revenue ... centers over 200 beds and holds one of the longest ... history. ...
Breaking Medicine Technology: