Navigation Links
Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
Date:3/31/2010

Scientists have uncovered what could be a very important clue in answering one of the most perplexing questions about cancer: why does it spread to the liver more than any other organ? In a new research report published in the April 2010 issue of Journal of Leukocyte Biology (http://www.jleukbio.org), scientists from New York University describe experimental results suggesting that the immune system may be the reason.

"Our work may open a new field of experimental therapeutics as combating the eventual development of liver metastases by targeting immune suppressive cells in the livers in patients with early cancer can have great benefit," said George Miller, a scientist involved in the work from the Departments of Surgery and Cell Biology at the New York University School of Medicine.

Miller and colleagues reached this conclusion after conducting experiments in mice. In the experiments, the researchers used mice that spontaneously developed pancreatic cancer because of a mutation (Kras-mutation) in the progenitor cells of the pancreas, as well as mice with advanced colon cancers that spread to the abdomen. They then studied the expansion of immune suppressive cells in the liver from a very early stage in the cancer development to determine the immune phenotype, stimulus for recruitment, inhibitory effects and tumor-enabling function of these cells. Results suggest that combating immune suppressive cells in the liver early after cancer development may prevent the spread of cancer to this vital organ.

"This study could represent one of those 'a-ha' moments in science where one idea or experiment opens up entirely new ways of approaching and understanding a problem," said Luis Montaner, Editor-in-Chief of the Journal of Leukocyte Biology. "Physicians have known that the spread of cancer to the liver is far too common to occur by chance. Now we know that the immune system likely plays a role in facilitating this process. The next step, obviously, is to learn more so we can prevent it from happening."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Silicon Valley Entrepreneur Launches Startup to Accelerate Tech Entrepreneurship in Upstate New York
2. The Five Best Valentines Day Gifts Youve Never Heard of - Starting Under $20
3. Stopping schizophrenia before it starts?
4. St. Augustine Elks to Start Elks Kids Fit Club
5. All for Haiti: America TeVe Starts a Humanitarian Bridge to Help Earthquake Victims in Haiti
6. Snatched from the Jaws of Retirement: Spiraling Treatment Costs Push Senior To Start Pan American Dental Tours
7. MYA Cosmetic Surgery have an uplifting start in 2010!
8. 2010 Will Be a Great Year for a Change! Start a New Career Now!
9. LogoLoft.com Posts 64% Sales Increase Over Previous Year As More Americans Start Their Own Businesses
10. Golden Living Kick-Starts Post-Acute Health IT with Microsoft HealthVault and Amalga UIS Connection
11. Request A Test Receives Weatherhead 100 Upstart Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... February 23, 2017 , ... Los Angeles-based weight loss surgeon ... TV’s “Mama June: From Not to Hot,” which will begin airing on February 24, ... known to millions from the 2012 reality television series, “Here Comes Honey Boo Boo.” ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rosica Communications, ... relations, content marketing, social media management, corporate communications, SEO and cause marketing, is ... and in nearby New Hampshire, Massachusetts and Canada, Rosica will focus on expanding ...
(Date:2/23/2017)... ... February 23, 2017 , ... On April 13, 2017, ... on “Doping in Sport: How the Culture Might Change,” in conjunction ... The symposium will be held at Pepperdine University in Malibu, California. , Sir ...
(Date:2/23/2017)... ... February 23, 2017 , ... Pink Pig Publishing LLC announces ... and explore the world from different perspectives. By providing a place for people ... understanding, increase empathy, and find greater happiness. , "Our approach to structuring ...
(Date:2/23/2017)... ... , ... Current Meditation , a new meditation concept ... U.S. starting this spring. Current Meditation focuses on “meditation for the modern world,” ... will be the first meditation concept in the U.S. offering franchising opportunities, setting ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 2017 Research and Markets has announced the ... - 2016" report to their offering. ... The latest research Oesophageal Cancer Drugs ... benchmarks in the global Oesophageal Cancer market. The research ... the key drugs marketed for Oesophageal Cancer and their clinical attributes? ...
(Date:2/23/2017)... Calif. , Feb. 23, 2017 ... company focused on the development and commercialization of ... pain, announced that it will release fourth quarter ... Thursday, March 2nd, 2017. AcelRx management will host ... Time (1:30 p.m. Pacific Time) on March 2 ...
(Date:2/23/2017)... York , February 23, 2017 ... arising from increasing caseload for varicose veins in their ... the globe are prompting the adoption of endovenous laser ... on global endovenous laser therapy market, published ... aftereffects of lifestyle choices and consequences of obesity have ...
Breaking Medicine Technology: