Navigation Links
Starchy, high carbohydrate diet associated with recurrence of colon cancer
Date:11/7/2012

BOSTON--Colon cancer survivors whose diet is heavy in complex sugars and carbohydrate-rich foods are far more likely to have a recurrence of the disease than are patients who eat a better balance of foods, a new study by Dana-Farber Cancer Institute researchers indicates.

The connection is especially strong in patients who are overweight or obese, the authors write. More than 1,000 patients with advanced (stage III) colon cancer participated in the study, one of the first to examine how diet can affect the chances that the disease will recur. The findings are being published online by the Journal of the National Cancer Institute and will appear later in the journal's print edition.

Although the results point to a potential hazard, for colon cancer patients, of a high-carbohydrate diet, the take-home message is not a conclusive "Eat less sugar," said lead author Jeffrey Meyerhardt, MD, MPH. "Our study certainly supports the idea that diet can impact the progression of colon cancer, and that patients and their doctors should consider this when making post-treatment plans. But further research is needed to confirm our findings."

Recent studies have shown that colorectal cancer survivors whose diet and activity patterns lead to excess amounts of insulin in the blood have a higher risk of cancer recurrence and death from the disease. High insulin levels can be produced by eating too many starchy and sugar-laden foods. In a previous study of advanced-stage colon cancer patients, Meyerhardt and his colleagues found that those with a typical "Western" diet -- marked by high intakes of meat, fat, refined grains, and sugar desserts -- were three times more likely to have a cancer recurrence than those whose diets were least Western. The new study was conducted to explore which component of the Western diet is most responsible for the increased risk of recurrence.

The study involved 1,011 stage III colon cancer patients who had undergone surgery and participated in a National Cancer Institute-sponsored Cancer and Leukemia Group B clinical trial of follow-up chemotherapy for their disease. Participants reported their dietary intake during and six months after the trial.

Researchers tracked the patients' total carbohydrates, as well as their glycemic index (a measure of how quickly blood sugar levels rise after eating a particular food), and glycemic load (which takes into account the amount of a carbohydrate actually consumed), and looked for a statistical connection between these measures and the recurrence of colon cancer.

They found that participants with the highest dietary levels of glycemic load and carbohydrate intake had an 80 percent increased risk of colon cancer recurrence or death compared with those who had the lowest levels. Among patients who were overweight or obese (had a body mass index above 25 kg/m2), the increase was even greater.

"In light of our and other's research, we theorize that factors including a high glycemic load may stimulate the body's production of insulin," Meyerhardt said. "That, in turn, may increase the proliferation of cells and prevent the natural cell-death process in cancer cells that have metastasized from their original site."

Meyerhardt added that while the study doesn't prove that diets high in glycemic load and carbohydrate intake cause recurrence of colon cancer, the results strongly suggest that such dietary factors play a role. "Our findings may offer useful guidance for patients and physicians in ways of improving patient survival after treatment."


'/>"/>
Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute
Source:Eurekalert  

Related medicine news :

1. Sleep apnea linked to increased risk for carbohydrate craving among diabetics
2. Controlling depression is associated with improved health for heart-failure patients
3. Study suggests too much risk associated with SSRI usage and pregnancy
4. Decline in incidence of heart attacks appears associated with smoke-free workplace laws
5. ESDM early intervention improves brain activity associated with social cues
6. Early menopause associated with increased risk of heart disease, stroke
7. Self-Harm Associated With Premature Death in Study
8. Physicians empathy directly associated with positive clinical outcomes, confirms large study
9. Study identifies genes associated with genomic expansions that cause disease
10. Rise in Pregnancy-Associated Cancers Not Fully Explained by Older Age
11. Study finds biologic therapies for rheumatoid arthritis not associated with increased cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Starchy, high carbohydrate diet associated with recurrence of colon cancer
(Date:5/24/2016)... ... May 24, 2016 , ... "ProText Layouts Vol. 3 is ... - CEO of Pixel Film Studios. , ProText Layouts Vol. 3 is a set ... Pro X . With ProText Layouts, video editors can create an lively typography video ...
(Date:5/24/2016)... Connecticut (PRWEB) , ... May 24, 2016 , ... ... Lyme and tick-borne disease research and education, today announced that it has named ... CEO of the Bonnie J. Addario Lung Cancer Foundation (ALCF) in San Francisco, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Researchers from Catholic ... designed to reduce bleeding complications from percutaneous coronary intervention (PCI). The data, presented ... in Orlando, FL, document a 40% reduction in risk-adjusted bleeding event rates over ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... the grand opening of ‘El Centro del Quinto Sol Wheel Park’ in Pueblo, ... ‘east side’ community to offer something special for this often overlooked neighborhood. Located ...
(Date:5/24/2016)... ... May 24, 2016 , ... Celebration is in ... kicked off its 5th Annual Photo Contest. The label contest is underway, and ... year's prizes include a GoPro Hero4, a 40-inch high-definition flat-screen television, an Apple ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... LONDON , May 23, 2016 ... Surgical Devices, Diagnostics and Monitoring, and Vision Care ... Market? Which areas are going to grow at the ... potential revenues to 2026, assessing data, trends, opportunities and ... tables, charts, and graphs. Discover the most lucrative areas ...
(Date:5/23/2016)... 2016 The global  reprocessed medical ... by 2022, according to a new study by Grand ... coupled with the lack of centralized support for waste ... the demand for reprocessed medical devices market. Additionally, the ... that of the original device is the high impact ...
(Date:5/20/2016)... , May 20, 2016 ... Antibody Technologies, Insulins, Growth Hormones, Recombinant Coagulation Factors ... Drugs - This New Study Reveals Selling Opportunities ... ,What is the future of ... latest technological and commercial analysis. Staying ahead in ...
Breaking Medicine Technology: