Navigation Links
Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
Date:10/18/2009

STANFORD, Calif. Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease.

The findings could lead to both a better understanding of the cause of lupus in humans and potential drug treatments for the disorder, which affects an estimated 1.5-2 million people in the United States.

"Just like in mice, in humans, if you don't clear the dying cells, then that predisposes you to lupus," said Lata Mukundan, PhD, a Stanford research associate and one of the first authors of the study to be published online in Nature Medicine Oct. 18. "If you look at patients with lupus, they have an inability to clear those dead cells."

Added Ajay Chawla, MD, PhD, assistant professor of endocrinology and senior author of the study: "The clearing away of dying cells is important. If they're not cleared away, they can provide antigens against ourselves, leading to development of autoimmunity."

Lupus is an autoimmune disease in which the body's system attacks its own cells. The chronic inflammation causes symptoms that can resemble other types of arthritis and rheumatic diseases, affecting the skin, heart, lungs, kidneys, joints and nervous system. The cause is unknown.

Mukundan, Chawla and their colleagues have uncovered one of the pathways by which macrophages sense and silently dispose of these dying cells a naturally-occurring process not previously understood by conducting lab experiments in vitro with mouse and human macrophages, as well as in genetically engineered mice.

Researchers hypothesized that a molecule in the nucleus of cells called PPAR-delta plays a pivotal role in orchestrating the timely disposal of dying cells by macrophages, the white blood cells that swallow and digest cellular debris
'/>"/>

Contact: Tracie White
traciew@stanford.edu
650-723-7628
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Molecular probe paints cancer cells in living animals, Stanford researchers find
6. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
7. IVF technique enables pregnancy without multiple births, Stanford researchers find
8. Stanford researchers find way to fight treacherous hepatitis B
9. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
10. Stanford researchers sniff out gene that gives dogs black fur
11. Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Childrens Research Hospital(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Pa. (April 24, 2014) - Contact lenses coated with an ... lens-related infections, reports a study in Optometry and ... Academy of Optometry . The journal is published by ... Wolters Kluwer Health . , Studies in animals and now ... the antimicrobial peptide melimine, according to the new research by ...
(Date:4/24/2014)... before, during and after colorectal surgery cut hospital stays ... researchers who led a study of the approach at ... is easier on patients before surgery, doing away with ... prescribed. After surgery, patients are encouraged to eat and ... recoveries. , Among findings published in the May 2014 ...
(Date:4/24/2014)... new Institute for Biomedical Sciences at Georgia State ... grant to develop novel therapeutics against Respiratory Syncytial ... Eunice Kennedy Shriver National Institute Of Child Health ... Health will support Plemper,s drug development goals of ... distinct alternative compound. , Infections by RSV, a ...
(Date:4/24/2014)... the corresponding terminology, and the relevance of palliation ... publications on randomized controlled trials (RCTs). This is ... Institute for Quality and Efficiency in Health Care ... report. , Together with external experts, IQWiG analysed ... lung cancer, malignant melanoma, and pancreatic cancer. For ...
(Date:4/24/2014)... than one out of three survivors of critical ... The Lancet Respiratory Medicine , and the ... than mentally. , It is one of the ... functional outcomes of critical care survivors, according to ... Medicine, and it highlights a significant public health ...
Breaking Medicine News(10 mins):Health News:Study supports safety of antimicrobial peptide-coated contact lenses 2Health News:Study supports safety of antimicrobial peptide-coated contact lenses 3Health News:New approach for surgery patients cuts hospital stays and costs 2Health News:New approach for surgery patients cuts hospital stays and costs 3Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 2Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 3
... ... Success”- a new DVD , Parents with teenagers who lack motivation and direction can now ... , ... 19, 2010 -- Parents with teenagers who lack motivation and direction can now access a ...
... matched the real personalities of the profile users , ... that Internet users favor idealized virtual identities, a new ... such as Facebook create profiles that stick closely to ... be more interested in fostering real communication and connections ...
... ... ... ... ...
... ... Morristown motorist and developed tinnitus, or severe ringing in her ears; she was granted compensation ... ... mail carrier represented by East Tennessee attorney Brack Terry of Terry, Terry & Stapleton ...
... ... snap. After one of the coldest Januarys in thirty years typical gas and electricity bills are ... ... energy bills of more than £200 this month because of the cold snap. After one of ...
... Contrast-enhanced magnetic resonance imaging (MRI) may help physicians differentiate ... and wrist enabling more targeted therapies unique to each ... of the American Journal of Roentgenology . Contrast-enhanced ... internal bodily structures. Rheumatoid ...
Cached Medicine News:Health News:Teen Motivation - with the 'Formula for Success' - a New DVD 2Health News:Facebook Profiles Don't Stretch the Truth 2Health News:Facebook Profiles Don't Stretch the Truth 3Health News:Facebook Profiles Don't Stretch the Truth 4Health News:MDS Announces Substantial Issuer Bid 2Health News:MDS Announces Substantial Issuer Bid 3Health News:MDS Announces Substantial Issuer Bid 4Health News:MDS Announces Substantial Issuer Bid 5Health News:MDS Announces Substantial Issuer Bid 6Health News:East Tennessee Attorney Brack Terry Obtains $120,000 Jury Award For Injured Mail Carrier 2Health News:It's Snow Joke as UK Gas and Electricity Bills Hit Record Highs -- Energyhelpline Calls for “Significant” Price Cuts 2Health News:Contrast-enhanced MRI could play a key role in differentiating between common types of arthritis 2
(Date:1/15/2014)... Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic ... . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) ... policy support, China,s orthopedic instrument ... total market size rising from 3.28 billion yuan in ...
(Date:1/15/2014)... 15, 2014  Novation, the leading health care supply chain ... value-added reseller (VAR) national contracts that expand its portfolio ... at lower costs. These include manufacturer product and service ... assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... Conn., Sept. 16 MedClean Technologies (OTC Bulletin Board: ... technology for the treatment and disposal of medical waste ... today announced it has signed a distribution agreement with ... organization with over 125 years of combined experience in ...
... Quarterly Dividend -- ABBOTT PARK, Ill., Sept. 16 ... ... ... // Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Medicine Technology:MedClean Technologies Signs Distribution Agreement with Trojan Energy Systems 2MedClean Technologies Signs Distribution Agreement with Trojan Energy Systems 3Abbott Declares 347th Consecutive Quarterly Dividend 2Abbott Declares 347th Consecutive Quarterly Dividend 3Abbott Declares 347th Consecutive Quarterly Dividend 4Abbott Declares 347th Consecutive Quarterly Dividend 5Abbott Declares 347th Consecutive Quarterly Dividend 6
Angled for temporal approach. Wire 14 mm rounded blades for patient comfort. Dull finish....
Angled for temporal approach. Open 14 mm rounded blades for patient comfort. Dull finish....
Angled upward 45 degrees for temporal approach. Open 14 mm blades....
Fenestrated 14 mm blades. Self-locking mechanism. Dull finish....
Medicine Products: