Navigation Links
Stanford scientists identify protein that keeps stem cells poised for action
Date:12/24/2009

STANFORD, Calif. Like a child awaiting the arrival of Christmas, embryonic stem cells exist in a state of permanent anticipation. They must balance the ability to quickly become more specialized cell types with the cellular chaos that could occur should they act too early (stop shaking those presents, kids!). Researchers at the Stanford University School of Medicine have now identified a critical component, called Jarid2, of this delicate balancing act one that both recruits other regulatory proteins to genes important in differentiation and also modulates their activity to keep them in a state of ongoing readiness.

"Understanding how only the relevant genes are targeted and remain poised for action is a hot topic in embryonic stem cell research," said Joanna Wysocka, PhD, assistant professor of developmental biology and of chemical and systems biology. "Our results shed light on both these questions." Wysocka is the lead author of the research, which will be published in the Dec. 24 issue of Cell.

Jarid2 works through a protein complex called PRC2, for Polycomb Repressive Complex 2. PRCs keep genes quiet by modifying DNA packaging proteins called histones. It's not quite tying a string around a brown paper package, but the concept is similar: Wrapping DNA up neatly around the histones helps it all fit in the tiny space and keeps it out of commission until the appropriate time. That's because, when wrapped, genes can't be converted into proteins to do the work of the cell. PRC2 adds a molecular "Do not open until Christmas" tag to ensure the DNA stays wrapped until it's needed.

PRC2 is necessary to regulate the expression of developmentally important genes in many types of cells. But Wysocka and her colleagues wanted to know specifically how it worked in embryonic stem cells. When they looked in mouse embryonic stem cells, they found that nearly all PRC2 is bound to a protein called Jarid2, which is more prevalent in embryoni
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Molecular probe paints cancer cells in living animals, Stanford researchers find
6. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
7. IVF technique enables pregnancy without multiple births, Stanford researchers find
8. Stanford researchers find way to fight treacherous hepatitis B
9. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
10. Stanford researchers sniff out gene that gives dogs black fur
11. Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Childrens Research Hospital(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... The Workgroup for Electronic Data Interchange ... of health IT to create efficiencies in healthcare information ... Small Providers.” The white paper by WEDI’s ICD-10 Testing ... ICD-10 testing by focusing on primary considerations and steps ... the October 1, 2015 implementation date. Download the ...
(Date:3/2/2015)... NEW YORK, NY (PRWEB) March 02, 2015 ... kicks off March 2–8 and will provide opportunities for people ... find new ways to help people with MS live their ... recognize progress made and to inspire others to join the ... , Multiple sclerosis, an unpredictable, often disabling disease of the ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 Four Seasons Resort ... celebrating its 25th anniversary this year, having officially opened its ... the luxury resort is honoring over 70 employees who started ... -- from amongst the approximately 400 original employees. The ... Resort’s Oceanfront Lawn. , This Four Seasons flagship ...
(Date:3/2/2015)... Houston, TX (PRWEB) March 02, 2015 ... CV? How should physicians request references? When are interviews ... physicians analyze employment opportunities?, Both training and practicing physicians ... answers to these questions and more at the PracticeLink ... March 18. The drop-in Job Fair is from 5:30 ...
(Date:3/2/2015)... 2015 Éminence Organic Skin Care, the ... excited to announce the launch of the Balance Collection, ... time-saving solution for those with combination skin. The Balancing ... divided jar to separate the products, consists of the ... Balancing Moisturizer Duo, also in a divided jar, contains ...
Breaking Medicine News(10 mins):Health News:WEDI Releases New White Paper on ICD-10 Testing for Small Providers 2Health News:Every Connection Counts During MS Awareness Week 2Health News:Every Connection Counts During MS Awareness Week 3Health News:Every Connection Counts During MS Awareness Week 4Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 2Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 3
... HealthDay Reporter , WEDNESDAY, Oct. 20 (HealthDay News) ... decades of warnings linking high-salt diets with an increase in ... stroke. A new Harvard study finds salt intake ... 50 years ago, an amount well above recommended guidelines, noted ...
... Health Initiative (WHI) report show that hormone therapy is associated ... as well as an increased risk of developing invasive breast ... social and preventive medicine at the University at Buffalo and ... in JAMA , says the breast cancers found in ...
... Tecnalia, through its Construction Unit, is participating in and ... Bimosyn. The aim is to develop pest control products ... environmentally friendly and less damaging for human health. The ... with the Swedish University of Agricultural Sciences (SLU) and ...
... that black rice a little-known variety of the grain ... population may help soothe the inflammation involved in allergies, ... Journal of Agricultural and Food Chemistry . Mendel ... several potential health benefits of eating black rice bran. Bran ...
... some women, the effects of breast cancer, the most common ... hospital. Now, researchers in the University of Missouri School of ... following chemotherapy and found that their environments and available support ... "A lot of times people get mentally and emotionally ready ...
... HealthDay Reporter , TUESDAY, Oct. 19 (HealthDay News) -- ... who decided to stop taking the cancer drug Gleevec (imatinib) ... The study, published online Oct. 19 in The Lancet ... the drug might go beyond long-term cancer control and offer ...
Cached Medicine News:Health News:Americans' Salt Intake Unchanged Over 50 Years 2Health News:Americans' Salt Intake Unchanged Over 50 Years 3Health News:Hormone therapy increases invasive breast cancer and mortality, WHI 11-year follow up finds 2Health News:Tecnalia develops environment-friendly and health-friendly pest control products 2Health News:Women fight the effects of chemotherapy long after treatment ends 2Health News:Some With Once-Deadly Leukemia Can Take a Break From Gleevec 2Health News:Some With Once-Deadly Leukemia Can Take a Break From Gleevec 3
(Date:3/2/2015)... March 2, 2015  Sarnova, parent company of ... the new www.tri-anim.com website, continuing Tri-anim,s ... distributor of respiratory, anesthesia and other critical care ... The site has many new features and ... online shopping and ordering easier and more efficient ...
(Date:3/2/2015)... -- Edison Investment Research, a leading ... full coverage of Abzena  Highlights of ... biotech analysts Christian Glennie and Dr ... offers a range of key services and technologies ... biological products. Antitope (immunogenicity testing, protein engineering, cell ...
(Date:3/2/2015)... , March 2, 2015 Attorney ... investigating potential claims on behalf of purchasers of ... or the "Company") (NasdaqGM: VTAE -News).  Such investors ... or his investor relations coordinator Eitan Kimelman ... The investigation concerns whether Vitae Pharmaceuticals and ...
Breaking Medicine Technology:Tri-anim Health Services Launches New Website Featuring Improved Product Selection and Ease of Ordering 2Tri-anim Health Services Launches New Website Featuring Improved Product Selection and Ease of Ordering 3Edison Initiates Coverage on Abzena 2SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Vitae Pharmaceuticals, Inc. 2
... Inc. (NASDAQ: MSON ), a medical ... therapeutic, ultrasonic products worldwide for wound debridement, cosmetic ... medical applications has announced their attendance at the ... (CSM), which was held in New Orleans, LA, ...
... SPRING, Md., May 2, 2011 The U.S. Food ... with diet and exercise, to improve blood glucose control ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) People with Type 2 ... a hormone that regulates the amount of glucose in ...
Cached Medicine Technology:Misonix Exhibits at Annual APTA-CSM Meeting 2Misonix Exhibits at Annual APTA-CSM Meeting 3FDA Approves New Treatment for Type 2 Diabetes 2
... Pipette is ideal for all liquid handling ... ergonomically-placed operating buttons, and various dispensing techniques ... diluting make this a lab favorite. It ... manual pipette without any adverse effects on ...
... Ergonomic Design for Unparalleled Comfort Pick one ... the balance. Notice the trigger and ejector positionsright ... because our pipettors are ergonomically designed to help ... of pipetting. Productivity In The Palm Of ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... Ergonomic Design for Unparalleled Comfort ... it. Notice the balance. Notice the trigger and ... left-handed. Thats because our pipettors are ergonomically designed ... long hours of pipetting. Productivity In The ...
Medicine Products: