Navigation Links
Stanford researchers unmask proteins in telomerase, a substance that enables cancer
Date:3/20/2008

. After a lifetime of cells dividing, the telomeres dwindle down to a length that eventually triggers the cell to stop replicating altogether or die.

Cancerous cells overcome that lifespan limitation by making telomerase, which repairs those snipped chromosome ends. Without shortening, the cells can divide forever. Telomerase is normally active in fetal cells, then shortly after birth it is turned off in all cells except normal tissue stem cells and some immune cells.

Since telomerase's discovery in cancerous cells in 1994, the idea has been that if a drug could block telomerase, chromosomes in those cancerous cells would eventually grow shorter and the cells would age and die just like any other cell in the body. But without knowing what proteins make up telomerase it's hard to design a drug to block it.

In the study, Artandi and first author Andrew Veneicher, an MD/PhD student, describe two protein components of telomerase. They also show that disabling one of the proteins brings telomerase to a grinding halt. Although the work was done in cells in a lab dish, the findings suggest that a drug blocking that protein may be a useful tool against cancer.

Artandi said one problem with studying telomerase is that it's available in such small quantities. Growing huge vats of cancer cells in the lab still only results in miniscule amounts of protein. Until recently, no technology was sensitive enough to analyze proteins at such minute levels.

"Many technical advances feed into our ability to make this discovery," Artandi said.

Artandi and his colleagues at the National Cancer Institute and Washington University School of Medicine took advantage of new technologies to get around the quantity problem. They chopped the massive telomerase complex into tiny protein pieces, then sent those pieces through a sensitive device that detected the pieces and compared the protein sequence to a genetic database that could match the
'/>"/>

Contact: Amy Adams
650-723-3900
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cancer detected earlier, faster, with new medical imaging, Stanford study finds
2. Stanford biologist awarded 2008 Sophie Prize in Norway
3. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
4. Hypnosis helped Stanford/Packard physicians pinpoint cause of childrens seizures
5. Hand-held computers prod older adults to exercise more, Stanford study shows
6. Video games activate reward regions of brain in men more than women, Stanford study finds
7. New nanotube findings by Stanford researchers give boost to potential biomedical applications
8. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
9. Computer calls can talk couch potatoes into walking, Stanford study finds
10. Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
11. Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Childrens Research Hospital(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Punzoné , the first line ... has a lot to celebrate this month. October marks Italian ... achievements and contributions of Americans of Italian heritage and Italians ... today it shares its favorite Italian cocktails and encourages everyone ... - even if it is only in a glass. ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Hastings and ... 30 years of service throughout the greater Phoenix area ... legal representation with regard to catastrophic automobile accidents. Statistics ... the country and throughout Arizona. As such, Hastings and ... for legal representation for those who have been injured ...
(Date:10/19/2014)... NATIONS, New York (PRWEB) October 19, 2014 ... United Nations Population Fund, welcomes news of a ceasefire ... of the more than 200 girls who were kidnapped ... "These girls have languished in captivity long enough, and ... families, schools and communities," stated Dr. Osotimehin. , "We ...
(Date:10/19/2014)... October 20, 2014 Recently, Top10BestSEOHosting.com ... announced that JustHost, GoDaddy and HostMonster are the ... VPS (Virtual Private Server) is the method of ... each of which has the appearance and capabilities ... is why the site pays close attention to ...
(Date:10/19/2014)... Charlotte, NC (PRWEB) October 19, 2014 ... muscle building program has just been released to ... throughout the online body building and fitness community. ... the attention of DietsAndFitnessGuides.com's Vin Delmonico prompting an ... the experience of hitting what is commonly known ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2
... , ... will be Offered Initially to the Academic and Research Communities , ... (PRWEB) -- Ziosoft®, Inc. a leader ... basic 2D/3D software free to the academic and research communities. The Windows®-based software ...
... ... in providing proven, non-surgical relief to millions of sufferers. , ... Dallas, TX (PRWEB) November 24, 2009 -- ... Shoulder Syndrome Diagnosis & Treatment seminar dates today. The three-day training seminars begin ...
... , SAN DIEGO, Nov. 24 US Farms, Inc., (Pink ... products is pleased to announce it has received formal certification ... Juice product. , Yan Skwara, CEO of ... that we have completed the certification process with the American ...
... , , 2009 ... New Transfer Agent, MEDICA 2009 , WESTON, Fla., Nov. 24 ... pleased to make available a current corporate update. , Since filing ... diligent in accomplishing additional goals, which are all part of a ...
... , , BATTLE CREEK, Mich., Nov. 24 ... and CEO of the W.K. Kellogg Foundation: , The W.K. ... need to comprehensively and substantially strengthen oral health care for ... of health reform represents a high water mark for oral ...
... behind reasoning that testing less is OK , TUESDAY, Nov. ... been upended in the past two weeks. , Not only ... the age at which it recommends women get their first ... Obstetrics and Gynecologists (ACOG) decided that adolescents should be spared ...
Cached Medicine News:Health News:Ziosoft Releases Free zioTerm Basic 2D/3D Software Application 2Health News:OTZ Announces 2010 Frozen Shoulder Syndrome Seminar Schedule 2Health News:OTZ Announces 2010 Frozen Shoulder Syndrome Seminar Schedule 3Health News:US Farms, Inc. Receives American Vegetarian Association Certification Approval for Aloe365(TM) Juice Product 2Health News:American Scientific Resources Inc. Issues Corporate Update 2Health News:American Scientific Resources Inc. Issues Corporate Update 3Health News:Statement of Support: Strengthening Oral Health Care is Key Part of Health Reform 2Health News:Recent Cancer Screening Changes Leave Many Confused 2Health News:Recent Cancer Screening Changes Leave Many Confused 3Health News:Recent Cancer Screening Changes Leave Many Confused 4
(Date:10/20/2014)... Lpath, Inc. (NASDAQ: LPTN ... official notification from the European Patent Office that ... supporting its iSONEP™ and ASONEP™ programs. ... 2087002, claims compositions of matter related to sonepcizumab, ... iSONEP and ASONEP. Sonepcizumab is an antibody that ...
(Date:10/19/2014)... 20, 2014 Shire plc (LSE: SHP, NASDAQ: ... Chief Financial Officer (CFO), has notified the Board of Directors of ... a new career opportunity as CFO of Severn Trent plc.  James ... company will commence a search for a new CFO immediately. ... has helped build and lead a high-quality finance team at Shire. ...
(Date:10/17/2014)... Oct. 17, 2014 With the recent ... function has come across several challenges in creating ... managing globalization.  The Medical ... dedicated to providing benchmarking and best practices across ... is a service composed of three stages: 1) ...
Breaking Medicine Technology:Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 2Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 3Lpath Granted Key European Patent Related to iSONEP and ASONEP Programs 4Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4Early Key Findings from the Medical Affairs Consortium Research 2
... ROSA, Calif., Feb. 14, 2011 / PRNewswire/ ... closed a $22 million Series D financing round led ... round were Split Rock Partners, Legacy Life Sciences, EDF ... and Asset Management Partners.  In connection with the financing, ...
... (Nasdaq: DYNT ) today announced results for its ... for the quarter ended December 31, 2010, were $8,199,347, compared ... for the six months ended December 31, 2010, were $16,118,635, ... year. Net income for the quarter ended ...
Cached Medicine Technology:Sonoma Orthopedic Products® Closes $22 Million Series D Financing 2Dynatronics Announces Fiscal Second Quarter Results 2Dynatronics Announces Fiscal Second Quarter Results 3Dynatronics Announces Fiscal Second Quarter Results 4
The Biopette E has a comfortable, ergonomic design. Fully motorized piston drive. Virtually eliminates pipetting forces. User-friendly operator interface. Simple, precise volume setting. Rechargelabl...
... The total ergonomic solution and best ... Soft, feather touch action and ultra ... strain, Stress-free tip ejection with long, ... easy volume identification, Accepts universal tips ...
... Electronic Pipette is ideal for all liquid ... display, ergonomically-placed operating buttons, and various dispensing ... and diluting make this a lab favorite. ... a manual pipette without any adverse effects ...
... in liquid handling, we are proud to ... that combines simplicity, comfort and functionality in ... the results of recent independent ergonomics studies, ... gives you the power to reach the ...
Medicine Products: