Navigation Links
Stanford researchers unmask proteins in telomerase, a substance that enables cancer
Date:3/20/2008

STANFORD, Calif. - One of the more intriguing workhorses of the cell, a protein conglomerate called telomerase, has in its short history been implicated in some critical areas of medicine including cancer, aging and keeping stem cells healthy. With such a resume, telomerase has been the subject of avid interest by basic scientists and pharmaceutical companies alike, so you'd think at the very least people would know what it is.

But researchers have been frustrated in their attempts to find the proteins that make up this complex. They know that it's a behemoth of an enzyme and is made up of more than just the two components they've gotten their hands on in the past. They also know what it does: it maintains the cell's genetic material in fetal cells, normal adult stem cells and in cancer cells.

What they don't know is what other proteins make up the massive telomerase complex. Until now, that is.

Researchers at Stanford University School of Medicine have identified two new proteins that make up the telomerase complex and have a lead on several more. This is the first significant step toward understanding the makeup of telomerase since 1999. The discovery of these two proteins provides new targets for cancer treatments, the researchers said.

"It's so surprising that we are discovering new components of this enzyme almost ten years after it was discovered," said Steven Artandi, MD, PhD, assistant professor of medicine and senior author of the study. The work will be published in the March 21 issue of Cell.

Telomerase is best known for its role in maintaining the cell's genetic material, the chromosomes. Every time a person's cell divides, it makes a second copy of the 46 chromosomes, then sends one copy to each of the two resulting cells. As that copying process proceeds, each replication snips a bit off the protective tips of the chromosomes, called telomeres. Those ever-shortening chromosomes are one reason cells age
'/>"/>

Contact: Amy Adams
650-723-3900
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cancer detected earlier, faster, with new medical imaging, Stanford study finds
2. Stanford biologist awarded 2008 Sophie Prize in Norway
3. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
4. Hypnosis helped Stanford/Packard physicians pinpoint cause of childrens seizures
5. Hand-held computers prod older adults to exercise more, Stanford study shows
6. Video games activate reward regions of brain in men more than women, Stanford study finds
7. New nanotube findings by Stanford researchers give boost to potential biomedical applications
8. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
9. Computer calls can talk couch potatoes into walking, Stanford study finds
10. Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
11. Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Childrens Research Hospital(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... MEMPHIS, Tenn. Researchers at Le Bonheur Children,s Hospital ... results of a clinical trial of a new drug ... illness of healthy adult volunteers intranasally infected with respiratory ... of lower respiratory tract infections in young children in ... comes from the labs of Infectious Disease Specialist John ...
(Date:7/24/2014)... 24, 2014 In signing the ... Obama cited the Atlanta BeltLine Workforce Partnership in ... across the country ( http://www.whitehouse.gov/ready-to-work ). The ... pillar of U.S. economic strategy and profiled successful ... recognition from President Obama highlights the power of ...
(Date:7/24/2014)... with high-throughput data generated by breast cancer biologists ... computational method to determine how gene networks are ... as they respond to potential cancer therapy agents., ... each other in laboratory-grown cells is described in ... PLOS Computational Biology . , The method ...
(Date:7/24/2014)... rare procedure occasionally performed during Jewish circumcisions that involves ... herpes simplex virus type 1 (HSV-1) transmissions documented in ... conducted by Penn Medicine researchers and published online ... Society found. The reviewers, from Penn,s ... in New York, Canada and Israel. , The practiceknown ...
(Date:7/24/2014)... E. Taylor, M.D., director of The Miriam Hospital,s ... 2014 Rhode Island Medical Journal special ... c virus infection (hep c or HCV) is ... address other health challenges, and improve health care ... States, Taylor says, include lack of funding earmarked ...
Breaking Medicine News(10 mins):Health News:RSV research breakthrough to help infected children 2Health News:President Cites Atlanta BeltLine Workforce Partnership in Healthcare as National Model 2Health News:President Cites Atlanta BeltLine Workforce Partnership in Healthcare as National Model 3Health News:President Cites Atlanta BeltLine Workforce Partnership in Healthcare as National Model 4Health News:President Cites Atlanta BeltLine Workforce Partnership in Healthcare as National Model 5Health News:Gene changes in breast cancer cells pinpointed with new computational method 2Health News:Gene changes in breast cancer cells pinpointed with new computational method 3Health News:Link between ritual circumcision procedure and herpes infection in infants examined 2Health News:Miriam Hospital physician advocates awareness, collaboration to combat peaking hep C virus 2Health News:Miriam Hospital physician advocates awareness, collaboration to combat peaking hep C virus 3Health News:Miriam Hospital physician advocates awareness, collaboration to combat peaking hep C virus 4
... Children who can read and have good phonetic skills - ... may still be poor spellers. In a paper published in ... Annett, at the School of Psychology of Leicester, UK, show ... be right-handed than other poor spellers. , The three-year study ...
... May 29 Alsius Corporation,(Nasdaq: ALUS ... (IVTM(TM)) therapies for critically ill patients, was ... L.P. to provide,intravascular temperature management products to ... the fifth contract we have been awarded ...
... to what is known about relationship between fitness and,diabetes, ... 2 diabetes in women is significantly increased as a ... Index (BMI), and a,combination of the two increases the ... at the 55th Annual Meeting of the American,College of ...
... a first for URAC, the,independent, non-profit accreditation organization ... has developed to help case management,practitioners assess patient ... instrument is a standardized assessment case managers,can voluntarily ... from any interested,parties, including purchasers, policy makers, consumers, ...
... that they have coordinated all the entertainment for Rhinestone ... Hotel Indigo, on,West End, from 7pm until midnight., ... a,place for you to connect with artists, friends and ... the world of country music quick, easy,and free!, ...
... firefighters study to be presented at ... American College of Sports Medicine, MISSOULA, ... Exercise Metabolism (Montana WPEM) will present a human,clinical study at ... that wildland firefighters who consumed a yeast based,(beta glucan) antioxidant ...
Cached Medicine News:Health News:Alsius Corporation Awarded Three-Year Agreement With Premier, Inc. 2Health News:Alsius Corporation Awarded Three-Year Agreement With Premier, Inc. 3Health News:Studies Define Type 2 Diabetes Risk Factors in Women, Adolescents 2Health News:Studies Define Type 2 Diabetes Risk Factors in Women, Adolescents 3Health News:Studies Define Type 2 Diabetes Risk Factors in Women, Adolescents 4Health News:URAC Develops New Case Management Patient Satisfaction Tool, Invites Public Input On Voluntary Survey Instrument 2Health News:URAC Develops New Case Management Patient Satisfaction Tool, Invites Public Input On Voluntary Survey Instrument 3Health News:DigitalRodeo.com Lines Up Entertainment for Rhinestone Cure 2Health News:Montana Center for Work Physiology and Exercise Metabolism Presents Firefighter Health Study 2
(Date:7/24/2014)... N.C. , July 24, 2014 ... has signed an Agreement with Kineticos, a ... consulting company. Kineticos will support LSI Medience in ... sepsis management, to demonstrate utility in clinical trials. ... shown potential utility in diagnosis of sepsis, prognosis ...
(Date:7/24/2014)... CAMPBELL, Calif. , July 24, 2014 /PRNewswire/ ... the development of novel interventional devices to facilitate ... United States Patent and Trademark Office has issued ... core technology behind the company,s Lazarus Cover TM ... The Lazarus ReCover is a single-component stent-retriever ...
(Date:7/24/2014)... "North America Orthopedic Braces and Supports Market Outlook to ... Orthopedic Braces and Supports market. The report provides value, ... and average price data (in US dollars), within market ... , Ankle Braces and Supports , Spinal Braces ... Photo - http://photos.prnewswire.com/prnh/20140723/129806 ...
Breaking Medicine Technology:LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2Lazarus Effect Receives Notice of Allowance for New US Patent Covering Core Protection Technology 2North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 2North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 3North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 4North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 5
The AutoSet Respond offers ResMeds unique AutoSet algorithm and product quality in a convenient, affordable model. The AutoSet algorithm responds to the patients pressure needs on a breath-by-breath ...
... The AutoSet Spirit is the premium ... flow generators, S7. The AutoSet algorithm responds ... breath-by-breath basis. The flow generator stores and ... software. The AutoSet devices combine integrated ...
These products are primarily for use with paediatric patients and for patients with difficult veins....
... Blood Collection Sets allow you to ... safety. The BD Vacutainer® Safety-Lok™ Blood ... be shielded with one-handed activation. This ... and infusion procedures. It comes with ...
Medicine Products: