Navigation Links
Stanford researchers synthesize compound to flush HIV out of hiding
Date:5/1/2008

Any hunter will tell you that when your quarry goes into hiding, you have to flush it out to get a good shot at it. Such is the case with HIV, the virus that causes AIDS.

Though antiretroviral "cocktails" can target an active infection, they cannot get at the virus when it retreats inside the host's T cells, where it may lie dormant for decades, waiting for an opportunity to burst forth in a fresh round of infection. What HIV hunters need is a good bird dog.

Now, Stanford chemist Paul Wender and his coworkers have found a way to synthesize better bird dogs, agents that can be tailored to flush HIV out into the open where the immune system and antiretroviral therapies can destroy it. Wender is senior author of a paper about the research in the May 2 issue of Science.

"We're not sure how far this will go, but certainly, from a theoretical point of view, it has promise of taking therapy to the next level-that is, addressing issues related to eradication of the disease, of the virus, at least," said Wender, the Francis W. Bergstrom Professor.

Wender and his co-workers Jung-Min Kee and Jeff Warrington have developed a way to synthesize prostratin and DPP, two compounds that occur naturally in plants, in the laboratory. Prostratin, found in the Mamala plant (Homalanthus nutans) that grows in the Samoan rainforest, has shown promise in previous studies as an activator of dormant HIV. DPP, a molecular relative of prostratin found in resin spurge (Euphorbia resinifera), which grows in arid regions, also has shown potential.

Research has been hampered, though, because the compounds are difficult to obtain, particularly in the quantities needed for practical lab work on their mode of action and therapeutic potential. The yield from both plants is low and highly variable; the availability of the plants is limited; and isolating the compound is difficult. Heavy harvesting of the wild plants, especially in Samoa, also could cause
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. High blood pressure still sneaking past doctors, Stanford study shows
2. Inaugural Stanford International Pro-Am Winner A Remarkable Story in Determination And the Powerful Impact of St. Jude Childrens Research Hospital
3. Defending Champion Woody Austin Helps Memphis Kick-off Countdown to 2008 Stanford St. Jude Championship
4. Stanford University School of Medicine to Address Improving Network Security and Management at EDUCAUSE Western Regional Conference 2008 Using Lancopes StealthWatch System for Network Behavior Analysis
5. YoNaturals to Install Healthy Vending Machines at Stanford University
6. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
7. Cancer detected earlier, faster, with new medical imaging, Stanford study finds
8. Stanford biologist awarded 2008 Sophie Prize in Norway
9. Jeffrey Modell Foundation and Talecris Biotherapeutics Expand Diagnostic Services for Primary Immunodeficiencies at Lucile Packard Childrens Hospital at Stanford
10. Hypnosis helped Stanford/Packard physicians pinpoint cause of childrens seizures
11. Hand-held computers prod older adults to exercise more, Stanford study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... (PRWEB) April 18, 2015 Lowcostcarinsuranceprice.com has ... theft rates have on auto insurance prices . ... high rates of vehicle theft may have to pay ... Some liability auto insurance policies can also offer protection ... can now be compared online on a single website: ...
(Date:4/18/2015)... April 18, 2015 Patients who undergo ... developing mesothelioma later in life, but the disease is ... that is unrelated to radiation. Surviving Mesothelioma has just ... website. Click here to read it now. ... the cases of 45 patients who had both a ...
(Date:4/18/2015)... In the past few weeks, TheBeautyPlace.com has been ... had to run maintenance on our shipping facilities to ... the PR Director. "It disrupted our regular shipping schedule ... back on track after having completed the maintenance." , ... systems which has not allowed some calls to come ...
(Date:4/18/2015)... On April 14th, 2015, Symantec released Volume 20 ... “exposes a tactical shift by cyberattackers.” With everything from frightening ... 2014 - almost a million a day - to how ... and patched by prominent manufacturers – as long as 204 ... a digital world can be fraught with peril, and that ...
(Date:4/18/2015)... “ ArcAngel ” was featured on NewsWatch as part ... latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... In a turbulent world, people may find themselves in dangerous ... their first move, but some situations can be avoided if ...
Breaking Medicine News(10 mins):Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:A Personal Safety Application was Featured on NewsWatch Television 2
... DALLAS June 3, 2009 A simple magnetic resonance ... the best treatment for some cancer patients, report researchers at ... that the amount of oxygen present in a tumor can ... to treatment. Tumors with little oxygen tend to grow stronger ...
... 2 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ("China Sky ... ), a leading,fully integrated pharmaceutical company producing over-the-counter drugs ... it obtained,approval from the State Food and Drug Administration ... drops. The document number for the drug is,2009S02063. , ...
... , This release is available in <A ... induce cells from pigs to transform into pluripotent stem ... capable of developing into any type of cell in ... world that this has been achieved using somatic cells ...
... than 25 years of experience to support growing demand ... June 2 Covance Inc. today announced Monte Jarvis ... for periapproval services. With more than 25 years ... global data management, Jarvis will oversee data management and ...
... June 2 The National Press Club Newsmaker ... Wednesday, June 3, with Argonne National Laboratory Director ... and cannot travel to Washington. , , ... ) , , The press conference ...
... Foundation,s Annual Salute to Service Award , , ... consecutive year, Jim Kerwin of Oxford Communications ( www.oxfordcommunications.bm ... that Oxford Communications will be the primary sponsor of ... Luncheon on June 17th and Celebrity Golf Tournament to ...
Cached Medicine News:Health News:Oxygen + MRI might help determine cancer therapy success, researchers find 2Health News:China Sky One Medical, Inc. Obtains SFDA Approval for Diclofenac Sodium Eye Drops 2Health News:China Sky One Medical, Inc. Obtains SFDA Approval for Diclofenac Sodium Eye Drops 3Health News:World first: Chinese scientists create pig stem cells 2Health News:World first: Chinese scientists create pig stem cells 3Health News:Covance Announces Monte Jarvis as Vice President of Global Data Management and Biostatistics for Periapproval Services 2Health News:Covance Announces Monte Jarvis as Vice President of Global Data Management and Biostatistics for Periapproval Services 3Health News:Jim Kerwin Announces Oxford Communications To Be the Title Sponsor of Bermuda Health Foundation Salute for the Second Year 2
(Date:4/17/2015)... ADELAIDE, Australia , April 17, 2015 ... the discovery and development of innovative therapeutics for the ... system, today announced the presentation of data from three ... American Association for Cancer Research (AACR) 106 th ... Philadelphia, PA USA. ...
(Date:4/16/2015)... , April 16, 2015  Hologic, Inc. ... cervical cancer screening study i published on-line ... peer-reviewed journal of the American Cancer Society. ... and the University of Pittsburgh Medical Center, supports current consensus ... recommend that women 30-65 years of age be ...
(Date:4/16/2015)... , April 16, 2015  Diplomat Pharmacy, Inc. ... Shannon Beltrand to their senior leadership team as ... be responsible for securing and properly monitoring Diplomat,s data, ... both internally and externally. Additionally, she will play key ... "We are very excited to have someone ...
Breaking Medicine Technology:Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Diplomat Names Shannon M. Beltrand as New CISO 2
... The Coolscope operates with a simple ... monitor display. Direct the mouse cursor ... macro image of the slide and ... The intuitive Graphic User Interface (GUI) ...
Advanced ergonomic design allows greater comfort even after long hours of use. The focus knob and stage handle are located equidistant from the operator, permitting one-handed operation in a natural ...
... laboratory microscope whose superior ergonomics, ... to make it the ideal ... designed to fit the user ... to fit the microscope. Optimized ...
Carbide drill bits, cutters, side cutting. Available in various sizes....
Medicine Products: