Navigation Links
Stanford/Yale study gives insight into subtle genomic differences among our own cells
Date:11/18/2012

that were there all along but had been missed in the earlier, mass analysis," Urban said. These CNVs had gone undetected because the fibroblasts in which they resided represented as little as a fraction of a percent of the fibroblasts in a biopsy sample. But any CNV in a fibroblast lucky enough to become the "parent" of the billions of iPS cells bearing its identical genomic "face" would now stick out like the proverbial sore thumb. Six out of the 20 different iPS cell lines sported at least one CNV unshared with the other lines, the investigators found. To the extent this reflects differences in parental fibroblasts, it means about 30 percent of the cells in human skin may harbor unique CNVs.

"This is a huge amount of cell-to-cell genetic variation," said Urban, who also participated in a recent study of human tissues conducted by the laboratory of Michael Snyder, PhD, professor and chair of genetics at Stanford. That study showed there can be distinct CNV patterns in kidney, pancreas and liver. "Rather than monoliths, our bodies may be mosaics composed of cells whose genomes differ. What we do not know is whether or when these differences are dangerous, irrelevant or beneficial."

That may depend on the organ, said Urban. "The more complicated something is, the more ways there are that something could go wrong with it. The brain is a particularly complicated organ. CNVs affecting cells in particular brain structures or areas could be playing a role in complex neurodevelopmental disorders such as schizophrenia and autism." Urban intends to find out, he said.


'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Hamstring ... area with stretching, soft tissue manipulation. Platelet rich plasma injections also have ... research to improve treatment outcomes. This localized treatment seems to address the ...
(Date:8/29/2015)... ... 29, 2015 , ... Vascular Health Sciences announced today that ... Arterosil HP, and that all claims and counterclaims have been irrevocably dismissed. , ... in the United States District Court for the Southern District of Texas for ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... center management, Decatur County Memorial Hospital recently transitioned management companies to partner with ... Center Management for their outpatient wound center. , Transitioning wound care management ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... at the Zoo to celebrate children helping children, a thank you to the ... West Ohio have contributed to the United Methodist initiative to end malaria deaths. ...
(Date:8/28/2015)... , ... August 28, 2015 , ... An article ... local pizza maker Paul LaRocco has gone through to open a pizzeria in Westchester. ... permitting process tends to take several months, but the current process, having already gone ...
Breaking Medicine News(10 mins):Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2
... Conn. Yale scientists have discovered the molecular pathway ... DNA mutations trigger a signaling cascade, resulting in programmed ... issue of Cell . Mitochondria are cellular ... generate most of the cell,s supply of energy. They ...
... HealthDay Reporter , THURSDAY, Feb. 16 (HealthDay News) ... anymore. In a new small study, women with severe ... drugs at the push of a button, a delivery ... conditions. Roughly 1.5-by-2.5 inches in size, the microchip ...
... patients with septic shock is safe and decreases vasopressor ... from researchers in France. "The benefits and ... remains a matter of controversy," said lead author Frdrique ... Crteil, France. "In our study, external cooling to achieve ...
... Montaner of the British Columbia Centre for Excellence in ... in this week,s PLoS Medicine that the cost-effectiveness of ... analyses have not yet taken into account the beneficial ... The authors comment: "the strategic value of expanded ...
... -- Most men who have surgery for prostate cancer can ... gland are not removed, according to a new study. ... number of his nerves that are spared will play a ... study followed 408 men who underwent a procedure to remove ...
... and grading, schoolteachers have a demanding job, and lately it,s ... challenges, thousands of Florida educators rely on a free, online ... teaching tools and resources, just when they need them. Soon ... Department of Education using federal Race to the Top funds ...
Cached Medicine News:Health News:How mitochondrial DNA defects cause inherited deafness 2Health News:Implanted Microchip Might Be Future of Drug Delivery 2Health News:Implanted Microchip Might Be Future of Drug Delivery 3Health News:Fever control using external cooling reduces early mortality in septic shock patients 2Health News: Nerve-Sparing Prostate Surgery Helps Men Retain Sexual Function 2Health News:$10.5 million grant will expand vast online hub for educators, by educators 2Health News:$10.5 million grant will expand vast online hub for educators, by educators 3Health News:$10.5 million grant will expand vast online hub for educators, by educators 4
(Date:8/28/2015)... 2015  CytomX Therapeutics, Inc., a biopharmaceutical company developing ... the filing of a registration statement on Form S-1 ... to a proposed initial public offering of its common ... the price range for the offering have not yet ... under the symbol "CTMX" on the NASDAQ Global Market. ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... ) has announced the addition of the ... report to their offering. Originally discovered ... as Yoshitomi Pharmaceutical Industries, Ltd) as an inflammatory ... by Senju Pharmaceutical Co., Ltd under the trade ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... ) has announced the addition of the ... Capacity and Production" report to their offering. ... Survey of Biopharmaceutical Manufacturing Capacity and Production is ... contract manufacturing organizations, current and projected future capacity ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Pranoprofen Market, 2010-2019 212th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2
... N.C., June 20, 2011 Pharmaceutical Institute, the ... pharmaceutical and biotech industry and a subsidiary of ... updates to its Therapeutic Area Essentials™ ... disease state training for pharmaceutical and biotech R&D ...
... dreamed of becoming a pilot for as long as he can ... child opting to play with toy planes instead of cars, and ... a family trip to Disney World.  At 8-years old Baniecki scribbled ... airline pilot and placed it into a time capsule.  Ten years ...
Cached Medicine Technology:Therapeutic Area Essentials "Class of 2011" Brings Current Disease State Training to Pharma 2Pilot's Dream Comes True Thanks to New Robotic Surgery 2Pilot's Dream Comes True Thanks to New Robotic Surgery 3Pilot's Dream Comes True Thanks to New Robotic Surgery 4
Stedman's Medical Dictionary includes charts and tables and navigation and search tools....
English and Spanish translations of all medical terms and phrases used in clinician-patient interactions....
ICDMeister is an electronic reference containing 15,000 of the 2006 ICD-9-CM diagnosis codes. Use whichever of the four different approaches for finding codes that you ....
CPTMeister is a coding reference based on the Physicians' Current Procedural Terminology (CPT) codes developed by the American Medical Association. It is an iSilo document composed of more than 2,000...
Medicine Products: