Navigation Links
Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Date:7/10/2008

Using an unusual microscope with a tip the size of a needle, Stanford researchers are now able to look at tiny fibers of working muscles in live humans, with minimum discomfort to the patienta development patients are sure to welcome.

This microendoscopy technique for viewing sarcomeresmicroscopic lengths of muscle fiber about 3 millionths of a meter longhas advantages over the uncomfortable alternative, a muscle biopsy in which a portion of the muscle is removed for examination.

Sarcomeres are the basic contracting engines of muscle. They generally pull in a coordinated fashion, allowing us to walk down the sidewalk or throw a sinking curveball from the pitcher's mound. But out-of-sync sarcomeres are implicated in muscular dystrophy and other diseases of diminished muscular control. It is thought that disease may change the length of sarcomeres and cause havoc with muscle control because the force exerted by muscle is critically dependent on length.

To observe sarcomeres in action, researchers from Stanford's Bio-X program have devised a needle-thin probe, which is inserted through the skin into muscle. When a flash of finely tuned laser light is sent through the probe, the sarcomeres respond with light of their own to form a snapshot of muscle in action.

The researchers see the images in real time on a display screen. A change in the depth of focus of the rapidly scanning device can provide a three-dimensional movie.

"This is a method that does not require any operative procedures," said Mark Schnitzer, an assistant professor of biology and of applied physics. For the first time, "it allows us to view individual sarcomeres in live humans."

The breakthrough was reported online in the journal Nature on July 6.

The technology could prove useful in understanding how muscles are altered by spinal cord injuries or strokes as well as muscular diseases, according to another of the researchers, Scott Delp, a professor of bioengineering and of mechanical engineering and, by courtesy, of orthopedic surgery.

Other areas of interest include biomechanics, orthopedic reconstructions, prosthetic devices and tendon transfers, in which tension adjustments are a crucial element for patients relearning how to walk or grasp. "If you measure the length of the sarcomeres during surgery, then you can adjust them to work at their optimal length, giving maximum muscle strength," Delp said.


'/>"/>

Contact: Dan Stober
dstober@stanford.edu
650-721-6965
Stanford University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find molecule that kills kidney cancer cells
2. Cancer cells revert to normal at specific signal threshold, Stanford researchers find
3. The Sir Allen Stanford Pediatric Fellowship Program Provides Close To CHF 1 Million to Support Kinderspital Zurich
4. Antibiotics can prevent wound complications of childbirth, Stanford/Packard study finds
5. GlaxoSmithKline Announces $500,000 in Fellowships at Stanford Graduate School of Business
6. Stanford Professor Barry M. Trost Visits WuXi PharmaTech and Gives Two Seminars
7. Vital Images Showcases the ViTAL Enterprise Solution at Stanford Universitys 6th Annual Face-Off
8. Brooks Brothers CEO at St. Jude Childrens Research Hospital(R) To Announce Partnership With Stanford St. Jude Championship
9. Stanford researchers synthesize compound to flush HIV out of hiding
10. High blood pressure still sneaking past doctors, Stanford study shows
11. Inaugural Stanford International Pro-Am Winner A Remarkable Story in Determination And the Powerful Impact of St. Jude Childrens Research Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , ... March 29, 2017 , ... AvePoint , ... North American office location in Richmond, Virginia, located at the Riverfront Plaza, 901 East ... by Lieutenant Governor of Virginia Ralph S. Northam and Mayor of Richmond Levar M. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Tuesday, March 28, 2017, is the annual ... the Diabetes Risk Test to find out if they are at risk for developing ... light up the evening sky by programming the LAX pylons the color red. Downtown’s ...
(Date:3/28/2017)... CARTERSVILLE, Georgia (PRWEB) , ... March 28, 2017 ... ... analyst to its award-winning team. Ruel Williamson brings his extensive knowledge of appraisals, ... been a leader in the real estate valuation industry for more than 40 ...
(Date:3/28/2017)... ... , ... The Thyroid Secret is a specialized 9-part documentary ... was recently launched on March 1, and Dr. Wentz discussed varied benefits and ... Izabella Wentz is a licensed pharmacist and a foremost thyroid specialist. After being ...
(Date:3/28/2017)... ... March 28, 2017 , ... Medforce Technologies, Inc., ... to announce it has joined the National Association for Home Care and Hospice ... ill, disabled, and dying Americans of all ages and the caregiver who provide ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Medicure Inc. ("Medicure") ... financial results for the year ended December 31, ... 2017. The results are being released later than ... statements will include the operations and balances of ... 2016.  This release and filing date meets TSX ...
(Date:3/28/2017)... March 28, 2017 The global emerging cancer ... of 13.45% from 2016 to 2023 and reach a ... Cancer is a chronic disease and is affecting ... cancer diagnostics market. This report is focused on emerging ... market growth is propelled due to factors such as: ...
(Date:3/28/2017)... 2017 The U.S. Food and Drug ... adults with moderate-to-severe eczema (atopic dermatitis). Dupixent is ... adequately by topical therapies, or those for whom ... used with or without topical corticosteroids. ... approving new and innovative therapies for patients with ...
Breaking Medicine Technology: