Navigation Links
Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Date:7/10/2008

Using an unusual microscope with a tip the size of a needle, Stanford researchers are now able to look at tiny fibers of working muscles in live humans, with minimum discomfort to the patienta development patients are sure to welcome.

This microendoscopy technique for viewing sarcomeresmicroscopic lengths of muscle fiber about 3 millionths of a meter longhas advantages over the uncomfortable alternative, a muscle biopsy in which a portion of the muscle is removed for examination.

Sarcomeres are the basic contracting engines of muscle. They generally pull in a coordinated fashion, allowing us to walk down the sidewalk or throw a sinking curveball from the pitcher's mound. But out-of-sync sarcomeres are implicated in muscular dystrophy and other diseases of diminished muscular control. It is thought that disease may change the length of sarcomeres and cause havoc with muscle control because the force exerted by muscle is critically dependent on length.

To observe sarcomeres in action, researchers from Stanford's Bio-X program have devised a needle-thin probe, which is inserted through the skin into muscle. When a flash of finely tuned laser light is sent through the probe, the sarcomeres respond with light of their own to form a snapshot of muscle in action.

The researchers see the images in real time on a display screen. A change in the depth of focus of the rapidly scanning device can provide a three-dimensional movie.

"This is a method that does not require any operative procedures," said Mark Schnitzer, an assistant professor of biology and of applied physics. For the first time, "it allows us to view individual sarcomeres in live humans."

The breakthrough was reported online in the journal Nature on July 6.

The technology could prove useful in understanding how muscles are altered by spinal cord injuries or strokes as well as muscular diseases, according to another of the researchers, Scott Delp, a professor of bioengineering and of mechanical engineering and, by courtesy, of orthopedic surgery.

Other areas of interest include biomechanics, orthopedic reconstructions, prosthetic devices and tendon transfers, in which tension adjustments are a crucial element for patients relearning how to walk or grasp. "If you measure the length of the sarcomeres during surgery, then you can adjust them to work at their optimal length, giving maximum muscle strength," Delp said.


'/>"/>

Contact: Dan Stober
dstober@stanford.edu
650-721-6965
Stanford University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find molecule that kills kidney cancer cells
2. Cancer cells revert to normal at specific signal threshold, Stanford researchers find
3. The Sir Allen Stanford Pediatric Fellowship Program Provides Close To CHF 1 Million to Support Kinderspital Zurich
4. Antibiotics can prevent wound complications of childbirth, Stanford/Packard study finds
5. GlaxoSmithKline Announces $500,000 in Fellowships at Stanford Graduate School of Business
6. Stanford Professor Barry M. Trost Visits WuXi PharmaTech and Gives Two Seminars
7. Vital Images Showcases the ViTAL Enterprise Solution at Stanford Universitys 6th Annual Face-Off
8. Brooks Brothers CEO at St. Jude Childrens Research Hospital(R) To Announce Partnership With Stanford St. Jude Championship
9. Stanford researchers synthesize compound to flush HIV out of hiding
10. High blood pressure still sneaking past doctors, Stanford study shows
11. Inaugural Stanford International Pro-Am Winner A Remarkable Story in Determination And the Powerful Impact of St. Jude Childrens Research Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... TransactRx announces the release of ... medical service claims by Pharmacy Benefit Managers that were submitted by Retail Clinics ... TransactRx Cross Benefit Clearinghouse receives standard professional medical claims submitted from the retail ...
(Date:5/25/2016)... FRANCISCO, CA (PRWEB) , ... May 25, 2016 , ... ... School of Nursing and Health Professions. She will lead a team of more than ... Team. Baker will begin her role as dean in late August. , Baker comes ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Laser ... to help turn back the hands of time of female aging. The ... childbirth. Women with symptoms such as leakage, laxity, itchiness and pain have reported ...
(Date:5/25/2016)... NJ (PRWEB) , ... May 25, 2016 , ... Researchers ... 2016 Annual COVD Meeting for their work on visual evoked potential and human attention. ... recent studies that used the Diopsys® NOVA™ ERG and VEP Vision Testing System ...
(Date:5/25/2016)... ... May 25, 2016 , ... HealthPostures ... will join America's leading engineers at the American Society of Safety Engineers Conference ... Congress Center. , Engineers, speakers and exhibitors from more than 40 countries ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 Niederländische Chirurgen ... die es Ärzten erlaubt, ihre Expertise weltweit zu ... kombiniert Live Streaming mit einer Instant-Messaging-Funktion und der ... Mediziner in Europa, Afrika, Asien und den ... die Plattform registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... Marziani has joined VMS BioMarketing as senior vice president of sales, announced Andrea ... Marziani will lead the company,s business development and sales team, exploring new opportunities for ... - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: