Navigation Links
Standard treatment for prostate cancer may encourage spread of disease
Date:10/1/2007

A popular prostate cancer treatment called androgen deprivation therapy may encourage prostate cancer cells to produce a protein that makes them more likely to spread throughout the body, a new study by Johns Hopkins researchers suggests.

Although the finding could eventually lead to changes in this standard treatment for a sometimes deadly disease, the Johns Hopkins researchers caution that their discovery is far too preliminary for prostate cancer patients or physicians to stop using it. The therapy is effective at slowing tumor growth, they emphasized.

David Berman, an assistant professor of pathology, urology and oncology at The Johns Hopkins University School of Medicine, and his colleagues identified the unsuspected potential problem with treatments that suppress testosterone after discovering that the gene that codes for the protein, called nestin, was active in lab-grown human prostate cancer cells.

Curious about whether prostate cancer cells in people also produce nestin, the researchers looked for it in cells taken from men who had surgery to remove locally confined cancers of their prostates and found none. But when they looked for nestin in prostate cancer cells isolated from patients who had died of metastatic prostate cancer - in which cancer cells spread out from the prostate tumor - they found substantial evidence that the nestin gene was active.

What was different, Berman speculated, is that androgen deprivation therapy, a treatment that reduces testosterone in the body, is generally given only when prostate cancers become aggressive and likely to metastasize.

Because prostate cancer growth is typically stimulated by testosterone, the treatment is thought to slow tumor growth and weaken the disease. Patients who eventually die because their disease metastasizes are almost certain to have received this type of therapy, he says.

Speculating that depriving cells of androgens might also,
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New standards for Human Research Safety
2. Angioplasty Should be the Standard
3. Presence of substandard drugs can pose concern for patients
4. Government Organisation Proposes Strict Guidelines For SubStandard Medical Devices
5. Researchers Feel The Need For Standards Of Practice In Immunoglobulin Therapy
6. Chinese Poultry Vaccine Could Be Sub-Standard: Expert
7. DMAA to Develop Disease Management Standards by December
8. Setting Standards: Benchmark Medical Tests to Gauge Accuracy of Medical Tests
9. Medical Colleges, Confident of Meeting Standards Before 90-days deadline
10. Cancer Care To Be Standardized
11. An International Growth Standard For Childs Releases By WHO
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... The Mesothelioma Applied Research Foundation ... Registry Act of 2015’. The bill was introduced in Congress yesterday by Representatives ... McCollum (D-MN), Joe Kennedy (D-MA), and Leonard Lance (R-NJ). The purpose of the ...
(Date:7/30/2015)... ... July 30, 2015 , ... Using the latest online digital technologies, happiness expert ... ways to prevent and manage major depression. , “Suicide is 100% preventable. The problem ... through the cracks and die needlessly everyday,” says Walker. “I’m out to end suicide. ...
(Date:7/30/2015)... ... July 30, 2015 , ... Boston Web Marketing ... Summit. Google Partners is the platform for search marketing agencies to communicate with ... tools necessary to run successful search marketing campaigns. Google Partners also affords businesses ...
(Date:7/30/2015)... ... July 30, 2015 , ... Between 2012 and 2014 HIV infection rates ... Florida on June 17th. Those untreated heroin use disorders share their needles and ... of dirty needles throughout the community. Ultimately Florida’s HIV infection rates have bolstered to ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... Ocean Hills ... available, including the very rare “no recommendations.” No recommendations means CARF found no areas ... is a notation that less than 3% of all facilities receive. In addition, Ocean ...
Breaking Medicine News(10 mins):Health News:Bill to Create Patient Registry for Deadly Cancer Introduced in Congress 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3Health News:Boston Web Marketing Attends Google Partners All-Stars Summit 2Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 2Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2
... looks to kill cells on organ,s surface, spare ... -- Patients are being recruited for a clinical trial ... pleural mesothelioma, a cancer of the lung,s lining that,s ... the standard treatment is to remove the affected lung. ...
... reduce hot flashes effectively. The good news is that cool herbs ... , ... Ann Arbor, MI (PRWEB) July 21, 2008 -- The hot summer ... merits of synthetic or bio-identical hormones. Too much complicated information overwhelms menopause ...
... the immune system interact, scientists at The Feinstein Institute for Medical Research ... spleen communicate. , ... Manhasset, NY (PRWEB) July 21, 2008 -- In ... system interact, scientists at The Feinstein Institute for Medical Research ...
... who need to be concerned about the heavily polluted ... cardiovascular problems for some spectators. , Two researchers ... Feinberg School of Medicine warn that for people in ... cause heart attacks and strokes within 24 hours of ...
... Kennedy DSc, Dean of Tufts University,s Gerald J. and ... announced the 3rd Annual Friedman School Symposium, a conference ... industry, policy-makers, academics and thought leaders in the coming ... 24th to 26th, 2008. , Fifteen experts will present ...
... healthy meals for less, , , MONDAY, July 21 (HealthDay News) ... your car, groceries are likely the next biggest expense in ... more and more of the average Americans income. , ... Then, in just the first five months of 2008, ...
Cached Medicine News:Health News:Lung Cancer Trial Targets Asbestos-Related Disease 2Health News:Menopause: Hot Flashes Can Be Reduced 90% without Hormones 2Health News:Menopause: Hot Flashes Can Be Reduced 90% without Hormones 3Health News:Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease 2Health News:Embargoed Until Monday, July 21 at 5 p.m. EST; Scientists Figure Out How the Immune System and Brain Communicate to Control Disease 3Health News:Beijing pollution may trigger heart attacks, strokes 2Health News:'Nutrition Agenda 2008' is focus of Tufts Friedman School Symposium 2Health News:'Nutrition Agenda 2008' is focus of Tufts Friedman School Symposium 3Health News:Stretch That Grocery List in Lean Times 2Health News:Stretch That Grocery List in Lean Times 3
(Date:7/30/2015)...  Lannett Company, Inc. (NYSE: LCI ) today ... Genuity 35th Annual Growth Conference on Wednesday, August 12, ... Hotel.  A webcast of the presentation ... encouraged to visit the web site at least 10 ... register, download and install any necessary software.  The presentation ...
(Date:7/30/2015)... 2015  Cleave Biosciences today announced that the ... the company a key patent providing the protection ... This newly issued patent, "Fused pyrimidines ... 9,062,026, allows for claims on the composition of ... inhibitor of p97, a critical enzyme that controls ...
(Date:7/30/2015)... CHICAGO , July 30, 2015 Flexpoint ... and financial services sectors, today announced that it has ... and Bryan Stuart to form Kastle Therapeutics, ... Chicago , will focus on acquiring, developing and ... needs. Target acquisition opportunities include select therapies already approved ...
Breaking Medicine Technology:Flexpoint Ford Announces Partnership with Alan MacKenzie and Bryan Stuart to Form Kastle Therapeutics 2Flexpoint Ford Announces Partnership with Alan MacKenzie and Bryan Stuart to Form Kastle Therapeutics 3
... Patients with breast or,colorectal cancer, two of the ... with Avastin(R) (bevacizumab) and Herceptin(R),(trastuzumab) following new data ... of Clinical Oncology (ASCO) annual meeting in Chicago ... will attend the meeting which,is the premier event ...
... May 15 Cytopia Limited,(ASX: CYT) today announced that ... the 2008 Annual Meeting of the American Society,of Clinical ... ASCO,s,website (http://www.asco.org ) from 9pm on Thursday 15 ... I evaluation of CYT997, a novel,cytotoxic and vascular disrupting ...
Cached Medicine Technology:New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients 2New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients 3New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients 4New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients 5New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients 6
Contoured design provides secure support and immobilization of the wrist and distal forearm while preserving finger mobility...
Designed to provide comfortable support, protection and immobilization MCP joint along with immobilization of the wrist...
Design allows for easy-one hand application to provide support and immobilization of the wrist while preserving finger mobility...
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
Medicine Products: