Navigation Links
St. Jude finds young age may give survival advantage to children with certain brain tumors
Date:5/29/2008

St. Jude Children's Research Hospital investigators have shown that children under 3 years old who have a brain tumor called diffuse pontine glioma (DPG) appear to have a better outcome than older children with the same cancer.

Results of the study, which appear in the advance online publication of the journal "Cancer," are important because clinicians have long believed that DPG was universally fatal. Moreover, it was assumed that clinicians had simply misdiagnosed the disease in children who responded to treatment and survived.

"Our findings show that children under 3 years with DPG can potentially respond better to treatment than older children," said Alberto Broniscer, M.D., assistant member in the St. Jude Department of Oncology and the paper's first author. "Unlike other previous studies in young children where the diagnosis of DPG was based on either CT scans or magnetic resonance imaging (MRI), the diagnosis of all our patients was based on MRI only. CT scans are not able to differentiate between DPGa tumor that occurs in the brainstemand other tumors, which originate in the same area with a better prognosis."

The researchers reviewed the medical records of 10 patients under 3 years of age with DPG. The median age of these patients was 2.2 years, and the median time between symptom development and actual diagnosis was 2.5 months. All children had the diagnosis of DPG based on radiological review of their MRIs at diagnosis.

All of the children received treatmenttwo with radiation, six with radiation plus chemotherapy, and two with chemotherapy only. Four of the children died, but six have survived for at least two years following this therapy, which is ineffective in older children with similar tumors. Based on these findings, the St. Jude team calculates that 45 percent of children under 3 years treated for DPG will survive for at least three years without experiencing tumor growth, and 69 percent of such children will survive.

From these results, the investigators concluded that distinct biological characteristics of DPG in children under 3 years compared to older children might account for their better response to radiation and chemotherapy. The researchers point to a similar finding with a type of glioma that originates in the cerebrum: Young children with high-grade gliomas originating in the cerebrum seem to have a better prognosis when compared to older children. Different biological properties also seem to play a role in the latter case.

Brainstem gliomas account for 10 to 15 percent of all brain tumors in children; and DPGs account for 80 percent of brainstem tumors in childhood. Although MRI revolutionized the diagnosis of DPG, no significant improvements have occurred in its treatment in children during the past 20 years, according to St. Jude researchers. The long-term survival of children with DPG has remained less than 10 percent despite treatment with radiation and chemotherapy.

The St. Jude team is now collecting tumor samples and performing extensive molecular analyses in order to gain a better understanding of the biology of DPGs in children. "We believe that the more we learn about DPGs, the more likely we will be able to design more effective treatments for children of all ages with this tumor," Broniscer said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Related medicine news :

1. USC study finds sex, age and ethnicity assciated with colorectal cancer survival
2. States Scorecard Finds Big Differences in Kids Health Care
3. Poll Finds That Physicians Long for Political Action
4. Study finds unique HIV vaccine formula elicits strong immune responses
5. Israeli study finds obstructive sleep apnea is health factor from day 1
6. Study finds that recalled Aqua Dots did contain poisonous chemical
7. Study finds 21st birthday binge drinking extremely common; can pose serious health hazards
8. Study Finds Gender Disparity in Community-Acquired Pneumonia
9. Study finds parents use cough medicines on under-2s despite the warnings
10. Presidential Candidates Health Care Plans Lack Key Reform Elements, Aspen Institute Finds
11. Chronic Medication Nation: Research Finds Chronic Health Problems Now Afflict More Than Half of All Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... CA (PRWEB) , ... May ... ... lectures and hands-on exercises, the Wharton Seminars for Business Journalists , ... better understanding of key business and economic issues.  This one-day program at ...
(Date:5/5/2016)... , ... May 05, 2016 , ... LELO ... self-love. Every day, LELO fans reach out via email, social media and on the ... upcoming up: “Is the way I masturbate ‘normal’ or ‘correct’?” , While some methods ...
(Date:5/5/2016)... Indianapolis, IN (PRWEB) , ... May 05, 2016 ... ... employee benefits advisory organization, announces McLaughlin & Smoak Benefits as the latest addition ... & Smoak Benefits has a dedicated team of compliance, wellness, human resources, and ...
(Date:5/5/2016)... Bremerton, WA (PRWEB) , ... May 05, 2016 , ... ... program serving the families of Bremerton, Port Orchard and communities west of Seattle. The ... Lowery, a 12 year local girl who died suddenly due to complications from the ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... grants the most heartfelt wishes of these children. The wishes provide hope ... President and CEO of Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Valeritas Holdings, Inc. (OTCQB: VLRX) ... offering (APO). This was accomplished via a reverse merger ... a private placement of approximately 5 million shares of ... Under the terms of the reverse merger, which ... will trade on the OTC Markets under the symbol ...
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute lymphocytic Leukemia Market ... to their offering.       (Logo: ... Acute Lymphocytic Leukemia Market and Competitive Landscape ... Lymphocytic Leukemia pipeline products, Acute Lymphocytic Leukemia ...
(Date:5/3/2016)... 3, 2016  As a teenager, an active and ... which damaged his heart. He continued enjoying sports and ... 2013, Shepherd,s heart was giving out and he was ... 20, 2013, the Mesa, Arizona ... Like a heart transplant, the SynCardia TAH-t is the ...
Breaking Medicine Technology: