Navigation Links
St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Date:1/27/2009

t. This measurement helps clinicians identify patients whose disease is highly responsive to chemotherapy and therefore might be cured with milder and less-toxic treatment; and also shows if remission induction therapy will likely fail.

The researchers performed a search of 476,796 inherited SNPs from two independent groups of children with newly diagnosed ALL: 318 patients on clinical trials at St. Jude and 169 patients on COG clinical trials.

The study discovered 102 of the inherited genetic variations that affected the level of residual leukemia or MRD. A high proportion (21 of 102) of these MRD-linked SNPs also predicted leukemic relapse; moreover, 21 SNPs linked eradication of MRD with greater exposure of the leukemic cells to the chemotherapy drugs.

For example, the researchers discovered five SNPs that are located in and around a gene called IL15, which codes for a protein called interleukin 15 that stimulates multiplication of leukemic cells. The finding was significant because previous studies showed that IL15 protects tumors from certain chemotherapy drugs; and that it is linked to both invasion of the central nervous system by leukemic cells and an increased risk of recurrence in that area following treatment. In the current study, the team found a link between the IL15 SNPs, increased levels of IL15 in leukemia cells, and an increased risk of high MRD at the end of induction therapy.

"Our finding that IL15 plays such an important role in the failure of chemotherapy suggests that this gene may be a marker we could use to predict outcome of therapy," Relling said. "IL15 might also represent a new target for novel drugs that knock out its activity and improve the outcome of patients with high levels of this interleukin."

In addition, 21 of the 102 SNPs that predicted MRD also significantly associated with the pharmacokinetics of two antileukemic drugs, etoposide and methotrexate, which are representative of the
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Verified Physicians a Must for Ensuring Quality Data From Online Surveys, Finds Frost & Sullivan
2. Manhattan Research Survey Finds That Physicians Overwhelmingly Support Commercially-Funded Continuing Medical Education
3. Study Finds High-Fructose Corn Syrup Contains Mercury
4. Cell phones dangerous for child pedestrians, UAB study finds
5. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
6. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
7. U.S. Government Finds 40% of People Currently Receiving Long Term Care are 18-64; Numbers Continue to Rise
8. UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases
9. Hearing Aids Offer Hope for Those Who Suffer from Persistent Ringing in the Ears, Better Hearing Institute Survey Finds
10. Survey Finds Employers Split on Impact and Cost of Migraine
11. Photos: Apples iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... March 27, 2015 Florida Hospital is excited ... the team’s exclusive health care provider for the 2015 and ... Hospital provides medical care and an athletic trainer for the ... kick off its season against the Cleveland Gladiators at Amalie ... partnership is extremely important to us as it gives us ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The federal ... that allege the statin medication increases the risk that ... Pfizer Inc.’s Motion to Dismiss four individual cases that ... Case Management Order issued in the U.S. District Court, ... determined that the dismissals were warranted because the plaintiffs ...
(Date:3/27/2015)... First Choice Emergency Room opened its ... located 12665 W Lake Houston Pkwy, Houston, Texas and is ... look forward to delivering the highest quality emergency medical care ... of First Choice Emergency Room Summerwood. , To ... to Summer Creek High School at First Choice Emergency Room’s ...
(Date:3/27/2015)... 27, 2015 Bleeding is one ... percutaneous coronary intervention (PCI), resulting in increased mortality, ... “risk-treatment paradox,” in which the highest-risk PCI patients ... treated less often with bleeding avoidance strategies than ... Mid America Heart Institute asked the question whether ...
(Date:3/27/2015)... New York, NY (PRWEB) March 27, 2015 ... is seeing more plastic surgery patients travel to the ... Tania Medina. The plastic surgery clinic is turning the ... for international cosmetic surgery patients — with trustworthy services ... important factor when selecting a plastic surgeon. Patients are ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3
... Public Health Message to Austin,s American,Heart Association Heart ... disease was the leading,cause of death among Texans ... deaths. People with heart disease are at an ... the flu. Therefore, the,U.S. Centers for Disease Control ...
... Broadcast Live to Over 500 Conference ... ... gastrointestinal (GI),specialists recently converged on Methodist Dallas Medical Center to,participate ... Texas Live 2008 featured advanced interventional procedures performed,at Methodist ...
... Milk and Related Products at the 79th National Sugar & ... ... /Xinhua-PRNewswire-FirstCall/ -- China Yingxia,International, Inc. (OTC Bulletin Board: CYXI) ("China ... nutritional food industry,engaged in the development, manufacture and distribution of ...
... have,flocked to warm bubbly waters to soothe their aching ... home spas of today that can cost,anywhere from $5,000 ... a backyard water oasis simply a luxury or could ... the soak?, To view the Multimedia News Release, ...
... Companies Will Be Expected to Cede Control, But,Retain Responsibility ... Today,s consumers want to have a,greater say about food ... around the globe expect the way they choose and ... study of consumers in five,countries., The study, called ...
... Health Protection Advisory Committee Member Says EPA,Analysis Justified ... The U.S. Environmental,Protection Agency (EPA) has taken a ... strengthening the nation,s air quality standard for lead,today, ... own analysis justifies an even lower lead standard, ...
Cached Medicine News:Health News:Huston Street Joins Mended Hearts with an Important Heart Health Message: Get Your Flu Shot! 2Health News:Huston Street Joins Mended Hearts with an Important Heart Health Message: Get Your Flu Shot! 3Health News:World-Renowned Physicians Converge on Methodist Dallas Medical Center for Largest Live Demonstration of Its Kind in Texas 2Health News:China Yingxia International, Inc. to Promote Benefits of Its Soy Milk Products Over Scandal-Stricken Cow's Milk in China 2Health News:China Yingxia International, Inc. to Promote Benefits of Its Soy Milk Products Over Scandal-Stricken Cow's Milk in China 3Health News:China Yingxia International, Inc. to Promote Benefits of Its Soy Milk Products Over Scandal-Stricken Cow's Milk in China 4Health News:Video: The Science Behind the Soak - a Coping Tool for Today's Changing World 2Health News:New Study Reveals Consumers Want Greater Say in Key Food Issues 2Health News:New Study Reveals Consumers Want Greater Say in Key Food Issues 3Health News:New Study Reveals Consumers Want Greater Say in Key Food Issues 4Health News:New Study Reveals Consumers Want Greater Say in Key Food Issues 5Health News:New EPA Lead Standard Significantly Improved to Protect Kids' Health 2Health News:New EPA Lead Standard Significantly Improved to Protect Kids' Health 3
(Date:3/27/2015)... , March 27, 2015 Levi & ... Pharmaceutical, Inc. (NASDAQ: OHRP ) concerning possible violations ... issued by the Company in connection with its study ... TO: http://zlk.9nl.com/ohr-pharmaceutical-ohrp or contact Joseph E. ... or by telephone at (212) 363-7500, toll-free: (877) ...
(Date:3/27/2015)... 27, 2015 /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, ... approved the grant of an aggregate of 236,070 options ... consultants of the Company pursuant to the Company,s Stock ... expire on the tenth anniversary of the date of ... anniversary of the date of grant and 50,000 are ...
(Date:3/27/2015)... MONTREAL , March 27, 2015 /CNW Telbec/ - ... Research-Based Pharmaceutical Companies (Rx&D), welcomes the 2015-2016 ... of a working group on the biopharmaceutical industry. However, ... medicines budget. "We commend the government,s intent ... the announcement of measures to promote Quebec,s ...
Breaking Medicine Technology:Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 2Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 3
... , NEW YORK, Oct. 2 Business ... today released "The Role of ISO 9000 in Document ... certification for its Document Review Services, Quality Management System. ... developing a document review Quality Management System (QMS), where ...
... Oct. 1 Algos Therapeutics Inc., a Minnesota-based global ... of Dr. Ganesh Iyer as its new president and ... , "We were incredibly fortunate to have attracted such ... Algos," stated Gary Smaby, Algos Board Chair and managing ...
Cached Medicine Technology:BIA Publishes White Paper: ISO 9000 Role in Document Review, Emphasizes 'Quality Equals Defensibility' 2BIA Publishes White Paper: ISO 9000 Role in Document Review, Emphasizes 'Quality Equals Defensibility' 3Algos Attracts CRO Veteran Dr. Ganesh Iyer as its New CEO 2
Ideal for breast compression and contouring breast cups....
Ideal for breast compression with adjustable hook and eye closure....
Female Mini-VEST, Front Closure, X-Firm...
Male Support Brief...
Medicine Products: