Navigation Links
St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Date:1/27/2009

t. This measurement helps clinicians identify patients whose disease is highly responsive to chemotherapy and therefore might be cured with milder and less-toxic treatment; and also shows if remission induction therapy will likely fail.

The researchers performed a search of 476,796 inherited SNPs from two independent groups of children with newly diagnosed ALL: 318 patients on clinical trials at St. Jude and 169 patients on COG clinical trials.

The study discovered 102 of the inherited genetic variations that affected the level of residual leukemia or MRD. A high proportion (21 of 102) of these MRD-linked SNPs also predicted leukemic relapse; moreover, 21 SNPs linked eradication of MRD with greater exposure of the leukemic cells to the chemotherapy drugs.

For example, the researchers discovered five SNPs that are located in and around a gene called IL15, which codes for a protein called interleukin 15 that stimulates multiplication of leukemic cells. The finding was significant because previous studies showed that IL15 protects tumors from certain chemotherapy drugs; and that it is linked to both invasion of the central nervous system by leukemic cells and an increased risk of recurrence in that area following treatment. In the current study, the team found a link between the IL15 SNPs, increased levels of IL15 in leukemia cells, and an increased risk of high MRD at the end of induction therapy.

"Our finding that IL15 plays such an important role in the failure of chemotherapy suggests that this gene may be a marker we could use to predict outcome of therapy," Relling said. "IL15 might also represent a new target for novel drugs that knock out its activity and improve the outcome of patients with high levels of this interleukin."

In addition, 21 of the 102 SNPs that predicted MRD also significantly associated with the pharmacokinetics of two antileukemic drugs, etoposide and methotrexate, which are representative of the
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Verified Physicians a Must for Ensuring Quality Data From Online Surveys, Finds Frost & Sullivan
2. Manhattan Research Survey Finds That Physicians Overwhelmingly Support Commercially-Funded Continuing Medical Education
3. Study Finds High-Fructose Corn Syrup Contains Mercury
4. Cell phones dangerous for child pedestrians, UAB study finds
5. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
6. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
7. U.S. Government Finds 40% of People Currently Receiving Long Term Care are 18-64; Numbers Continue to Rise
8. UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases
9. Hearing Aids Offer Hope for Those Who Suffer from Persistent Ringing in the Ears, Better Hearing Institute Survey Finds
10. Survey Finds Employers Split on Impact and Cost of Migraine
11. Photos: Apples iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... LI, New York (PRWEB) April 28, 2015 ... Therapy in Commack. 2015 will be the third year that ... attention for the entire week. Hands On is offering some ... be offered. "What better time of the year could there ... Hands On. "All women deserve pampering and this is a ...
(Date:4/28/2015)... April 28, 2015 The buyer power ... out of 5, indicating a medium level of buyer ... and suppliers have equal power during negotiations. One factor ... than purchasing a health insurance policy from an insurance ... Humana), buyers can choose to self-fund their own policy ...
(Date:4/28/2015)... 28, 2015 Dead or damaged trees can ... property. In many cases, tree removal by a skilled team ... eliminate the threat. , In their latest article ... removal available to property owners today. Each method requires skill ... job well done. , The article states that, “Tree removal ...
(Date:4/28/2015)... Washington, DC (PRWEB) April 28, 2015 ... for Medicare-Medicaid dual eligibles reached 2.2 million in ... Services, Inc.’s (AIS) new Medicare-Medicaid Dual Eligibles ... all programs and plans serving the dual-eligible community. ... Dual Eligibles Database began tracking initiatives in January, ...
(Date:4/28/2015)... (PRWEB) April 28, 2015 “ Gwee ... monthly Tech Report, which features the latest and coolest ... expert and special reporter for NewsWatch, conducted the review ... innovative iPad case. , As much as everyone loves ... the screen. Aside from looking at them, it's even ...
Breaking Medicine News(10 mins):Health News:Commack Massage Therapy and Wellness Day Spa Dedicates Time To Celebrate Women 2Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 2Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 3Health News:New Data for Group Health Insurance Procurement Category Market Research Report from IBISWorld 4Health News:Tree Removal Methods and Services Discussed in Recent Article by Precision Tree Services 2Health News:Enrollment in Duals Programs Increases 14%, New AIS Database Finds 2Health News:The Most Innovative iPad Case was Featured on NewsWatch Television 2
... SILVER SPRING, Md., July 6 The Obesity Society, the ... obesity, is pleased to announce the selection of Francesca M. ... Ms. Dea comes to The Obesity Society with an ... and media relations. , , According to Robert Kushner, ...
... famotidine effective at curtailing ulcers , MONDAY, July 6 (HealthDay ... in people taking low-dose aspirin, often to reduce the risk ... phase III trial included 404 patients taking 75 milligrams to ... to take either 20 milligrams of famotidine or a placebo ...
... in those with advanced chronic heart failure, have an ... to new research from researchers at the University of ... in the European Heart Journal , also suggest ... risk of death in heart failure patients, contradicting previous ...
... 6 SCAN Health Plan of Arizona has announced that ... Studios today. This partnership allows SCAN Health Plan to regularly ... and weekend shows. , , SCAN also will serve ... Gila River Casino Club 55+. This initiative is part of ...
... future of organ transplantation could include microscopic beads that ... new organ, Medical College of Georgia researchers say. ... at the MCG Center for Molecular Chaperone/Radiobiology and Cancer ... with skin grafts. The degradable microparticles deliver the ...
... Blood Types - Patients Need YOU , , NEW ... York Blood Center (NYBC) and its divisions in Manhattan, Long ... call upon the community to please give blood this month. ... of all blood types and ethnicities are encouraged to donate ...
Cached Medicine News:Health News:The Obesity Society Selects Executive Vice President 2Health News:Drug Limits Stomach Trouble in Patients Taking Low-Dose Aspirin 2Health News:Atrial fibrillation linked to increased hospitalization in heart failure patients 2Health News:Arizona's AM 1230 KOY to be Broadcast from SCAN Health Plan Studios 2Health News:Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs 2Health News:Who Says Negatives Can't Be Positive? 2Health News:Who Says Negatives Can't Be Positive? 3
(Date:4/28/2015)... , April 28, 2015 ANI Pharmaceuticals, ... Company plans to release its first quarter 2015 financial ... of the U.S. financial markets. The earnings press release ... the Company,s website, www.anipharmaceuticals.com . ... Officer, and Charlotte C. Arnold , Vice President ...
(Date:4/28/2015)... CARLOS, Calif. , April 28, 2015  Rosa ... expertise in drug-disease modeling and simulation, today announced its ... in the exciting field of Quantitative Systems Pharmacology (QSP). ... in pharmaceutical drug development.  ... Rosa,s ...
(Date:4/28/2015)...  Boston Scientific Corporation (NYSE: BSX ) ... quarter ended March 31, 2015, compared to the ... to $1.800 billion.  This represents 6 percent operational ... and flat revenue on a reported basis, all ... achieved adjusted earnings per share of $0.21 for ...
Breaking Medicine Technology:ANI Pharmaceuticals Schedules Conference Call for First Quarter 2015 Financial Results 2Rosa & Co. is the Lead Partner for the Quantitative Systems Pharmacology (QSP) Congress in Basel, Switzerland and Will Present the Keynote Address 2Rosa & Co. is the Lead Partner for the Quantitative Systems Pharmacology (QSP) Congress in Basel, Switzerland and Will Present the Keynote Address 3Boston Scientific Announces Results for First Quarter 2015 2Boston Scientific Announces Results for First Quarter 2015 3Boston Scientific Announces Results for First Quarter 2015 4Boston Scientific Announces Results for First Quarter 2015 5Boston Scientific Announces Results for First Quarter 2015 6Boston Scientific Announces Results for First Quarter 2015 7Boston Scientific Announces Results for First Quarter 2015 8Boston Scientific Announces Results for First Quarter 2015 9Boston Scientific Announces Results for First Quarter 2015 10Boston Scientific Announces Results for First Quarter 2015 11Boston Scientific Announces Results for First Quarter 2015 12Boston Scientific Announces Results for First Quarter 2015 13Boston Scientific Announces Results for First Quarter 2015 14Boston Scientific Announces Results for First Quarter 2015 15Boston Scientific Announces Results for First Quarter 2015 16Boston Scientific Announces Results for First Quarter 2015 17Boston Scientific Announces Results for First Quarter 2015 18Boston Scientific Announces Results for First Quarter 2015 19Boston Scientific Announces Results for First Quarter 2015 20Boston Scientific Announces Results for First Quarter 2015 21Boston Scientific Announces Results for First Quarter 2015 22Boston Scientific Announces Results for First Quarter 2015 23Boston Scientific Announces Results for First Quarter 2015 24Boston Scientific Announces Results for First Quarter 2015 25
... AT&T * today announced that the Arkansas Department ... mobile flu clinic solution to help the agency more efficiently ... to extend the use of the application to other year-round ... As an important part of its mission to ...
... 2011 Inhibitex, Inc. (Nasdaq: INHX ) today ... shares of its common stock, at a purchase price of ... The net proceeds to Inhibitex from the sale of the ... are expected to be approximately $44 million.  Inhibitex has granted ...
Cached Medicine Technology:Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 2Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 3Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 4Inhibitex Prices $47 Million Public Offering 2Inhibitex Prices $47 Million Public Offering 3
Ultraview 1700 Central Monitor...
The Hypervisor VI is a solution for telemetry, LAN and wireless LAN networking. It includes bi-directional communication with Mindray bedside patient monitors and can store waveforms and numeric info...
DS 7600 Central Station...
... The MedSystem III DLE (Drug List ... dimension to drug infusion technology. The instrument ... features and clinical versatility in an unparalleled ... Calculation, the MedSystem III Infusion System simplifies ...
Medicine Products: