Navigation Links
St. Jude finds more than 100 gene variations linked with response to leukemia treatment
Date:1/27/2009

Scientists from St. Jude Children's Research Hospital and the Children's Oncology Group (COG) have discovered in children with acute lymphoblastic leukemia (ALL) scores of inherited genetic variations that clinicians might be able to use as guideposts for designing more effective chemotherapy for this cancer.

The findings are important because although cure rates for ALL exceed 80 percent, patient responses vary significantly to the same drugs. Much of this variance has been unexplained. The newly discovered genetic variations, however, will likely give scientists a clearer understanding of why treatments fail in some patients with ALL, and how to predict early in treatment which children could be successfully treated with less aggressive treatment.

"This study differs from most previous investigations of gene variations linked to chemotherapy outcome because those studies focused only on the genes of the leukemic cells themselves," said Mary Relling, Pharm.D., St. Jude Pharmaceutical Sciences chair. "We focused on genomic variation that is inherited and affects all cells in the body, not just the leukemic cells." Relling is the senior author of a report on the team's study that appears in the January 28, 2009, issue of the Journal of the American Medical Association.

In their research, St. Jude scientists collaborated with a team from COG, a worldwide group of medical institutions that cooperate in laboratory research studies and clinical trials of cancer treatments for children. Instead of studying genetic variations acquired by leukemia cells, scientists identified small genetic variations the children inherited from their parents.

The researchers then determined which of those small, inherited variations, called single-nucleotide polymorphisms (SNPs), were associated with minimal residual disease (MRD). MRD is the small number of leukemic cells that survive after remission induction therapythe initial treatmen
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Verified Physicians a Must for Ensuring Quality Data From Online Surveys, Finds Frost & Sullivan
2. Manhattan Research Survey Finds That Physicians Overwhelmingly Support Commercially-Funded Continuing Medical Education
3. Study Finds High-Fructose Corn Syrup Contains Mercury
4. Cell phones dangerous for child pedestrians, UAB study finds
5. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
6. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
7. U.S. Government Finds 40% of People Currently Receiving Long Term Care are 18-64; Numbers Continue to Rise
8. UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases
9. Hearing Aids Offer Hope for Those Who Suffer from Persistent Ringing in the Ears, Better Hearing Institute Survey Finds
10. Survey Finds Employers Split on Impact and Cost of Migraine
11. Photos: Apples iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... the category creator and world leader in healthy chocolate, the ... improve individual lives worldwide through its exclusive and healthy chocolate ... Austin, Texas based "Xocai Activ Drink" author, is scheduled to ... promote the up and coming mxicorp.com/company/igc Eric Worre engagement to ... a leader in the Network Marketing Profession for over 25 ...
(Date:7/24/2014)... Dr. Henry H. Ting, a nationally recognized ... appointed senior vice president and chief quality officer at ... role, he will oversee the hospital's clinical quality and ... quality initiatives and interprofessional teams at the local, regional ... Door-to-Balloon Alliance, a collaboration of more than 1,000 hospitals ...
(Date:7/24/2014)... 2014 The Traffic and Leads ... designed to help users generate traffic and leads has ... of excitement throughout the internet marketing community. The excitement ... HonestyFirstReviews.com’s Tiffany Hendricks prompting a comprehensive review of the ... in internet marketing will tell you, it can be ...
(Date:7/24/2014)... HI (PRWEB) July 24, 2014 ... completion this month of its $3 million renovation of ... new Lokelani presidential/residential three-bedroom suites, just in time to ... Maui. , With design direction from the internationally-acclaimed BraytonHughes ... suites—the largest on the property and the largest in ...
(Date:7/24/2014)... of Association Executives (ASAE) announced its 2014 Power of ... American Society of Anesthesiologists (ASA). , The ASA ... A Gold Award, one of the top honors from ... of the world through education on the global anesthesia ... care. , ASA was also honored with a Power ...
Breaking Medicine News(10 mins):Health News:Austin, Texas Based "Xocai Activ Drink" Author, Adam Paul Green, to Visit Niigata Japan to Promote mxicorp.com/company/igc Eric Worre Speaking Engagement 2Health News:Austin, Texas Based "Xocai Activ Drink" Author, Adam Paul Green, to Visit Niigata Japan to Promote mxicorp.com/company/igc Eric Worre Speaking Engagement 3Health News:Austin, Texas Based "Xocai Activ Drink" Author, Adam Paul Green, to Visit Niigata Japan to Promote mxicorp.com/company/igc Eric Worre Speaking Engagement 4Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 2Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 3Health News:Traffic And Leads Training Academy - Review Examining Jeff Johnson’s New IM Course Released 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 3Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 4Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 5
... a protein called IGF-1 not entirely successful, studies find ... that prostate cancer can be treated successfully just by ... factor (IGF-1) has been undermined by two new studies. ... a number of drug companies and academic researchers, stimulated ...
... Consumers flooded Castle Connolly,s,website http://www.castleconnolly.com in ... Top Doctors," offered in collaboration with the,award-winning newspaper ... alone,Tuesday, April 29th, Newsday,s online users viewed Castle ... to our usual heavy traffic,from other sources," said ...
... MIRAMAR, Fla., May 1 Nipro Diabetes Systems ... time to the market. The,pump helps control blood ... and 2,diabetes. Built for safety, reliability, accuracy and ... screens for easy programming.,Developed and manufactured in the ...
... to Make Ends Meet, HARRISBURG, Pa., May 1 ... the rising costs of health care,would be greatly helped ... care insurance for all, a Department of Agriculture official ... Food Bank, Deputy Secretary,of Agriculture Cheryl Cook said passage ...
... 1 Physicians Healthcare Management,Group, Inc. (Phyhealth) ... organizations (HMOs) in partnership with physicians, today,announced ... as medical director,of Phyhealth Plan Corporation., ... Orlando, Florida, who has,extensive experience as the ...
... with pregnancy outcomes, CHICAGO, May 1 With ... wants to remind mothers-to-be,that maintaining good oral health is ... Research suggests there may be an association between maternal ... In addition, a,recent study says that pregnant women with ...
Cached Medicine News:Health News:Complications Found in Proposed Prostate Cancer Treatment 2Health News:Castle Connolly's 'Long Island's Top Doctors' Published in Newsday Generates More Than 1.1 Million Views of Top Doctors' Profiles in Single Day 2Health News:Photo: Introduction of the Amigo Insulin Pump Offers a Lifestyle Where 'Life Has No Limits' 2Health News:Pennsylvania Agriculture Official Says Passage of PA ABC Crucial to Rural Communities 2Health News:Phyhealth Appoints Gerald H. Priceman as Medical Director 2Health News:Phyhealth Appoints Gerald H. Priceman as Medical Director 3Health News:American Dental Association Stresses Good Oral Health During Pregnancy 2
(Date:7/24/2014)... Inc. (NASDAQ: QCOR ) today reported financial results ... Ended 06/30/14Three Months Ended 06/30/13 ,  Percentage ChangeGAAP Net Sales ... Net Sales , $278.8 Million , $196.1 Million , ... $1.12 , 37% Non-GAAP Diluted EPS , ... Months Ended 06/30/14Six Months Ended 06/30/13 ,  Percentage ChangeNet Sales ...
(Date:7/24/2014)... 24, 2014 Cancer patients in the west of ... cancer treatment closer to home when a new radiotherapy center ... Medical Systems (NYSE: VAR ) has been selected ... in June for four TrueBeam™ medical linear accelerators. ... and efficient radiotherapy and radiosurgery treatments, will replace older treatment ...
(Date:7/24/2014)...  Bruin Biometrics (BBI), a pioneer in biometric-sensor ... weeks of clinical briefings to over 200 pressure ... substantial concurrence on both the clinical validity of ... BBI,s SEM Scanner. "From our ... drawn from the European Wound Management Association (EWMA) ...
Breaking Medicine Technology:Questcor Reports Record Second Quarter Financial Results 2Questcor Reports Record Second Quarter Financial Results 3Questcor Reports Record Second Quarter Financial Results 4Questcor Reports Record Second Quarter Financial Results 5Questcor Reports Record Second Quarter Financial Results 6Questcor Reports Record Second Quarter Financial Results 7Questcor Reports Record Second Quarter Financial Results 8Questcor Reports Record Second Quarter Financial Results 9Questcor Reports Record Second Quarter Financial Results 10Questcor Reports Record Second Quarter Financial Results 11Questcor Reports Record Second Quarter Financial Results 12Questcor Reports Record Second Quarter Financial Results 13Questcor Reports Record Second Quarter Financial Results 14Questcor Reports Record Second Quarter Financial Results 15Questcor Reports Record Second Quarter Financial Results 16Questcor Reports Record Second Quarter Financial Results 17Questcor Reports Record Second Quarter Financial Results 18Questcor Reports Record Second Quarter Financial Results 19Questcor Reports Record Second Quarter Financial Results 20Questcor Reports Record Second Quarter Financial Results 21Questcor Reports Record Second Quarter Financial Results 22Questcor Reports Record Second Quarter Financial Results 23Questcor Reports Record Second Quarter Financial Results 24Questcor Reports Record Second Quarter Financial Results 25Questcor Reports Record Second Quarter Financial Results 26Questcor Reports Record Second Quarter Financial Results 27Questcor Reports Record Second Quarter Financial Results 28Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 2Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 3Bruin Biometrics Secures Support of EU Scientific Community for its SEM Scanner Technology 2
... ADDISON, Texas, May 11, 2011 ULURU Inc. ... scheduled a conference call to discuss the first quarter ended March ... on Tuesday, May 17, 2011 at 9:00 a.m. Eastern Time. ... for international callers dial (850) 429-1388 (access code 23748#) five to ...
... May 11, 2011 HCB Health, one of the ... and the leading healthcare agency in the Southwest, won ... the 22nd annual Manny Awards, a national competition honoring ... for a consumer campaign supporting Sound Surgical Technologies, VASER® ...
Cached Medicine Technology:ULURU Inc. Announces Conference Call to Discuss Financial Results for the First Quarter Ended March 31, 2011 and to Provide a Business Update 2HCB Health Wins Manny Award for Best Medical Device Campaign 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: