Navigation Links
St. Jude finds link between cellular defense processes, showing how cancer cells survive
Date:12/19/2007

en macrophages phagocytosed special beads carrying pieces of germs, there was a rapid movement of the autophagy-associated LC3 proteins to the developing phagosome. The scientists then fed particles called zymosan (killed yeast cells) to macrophages that lacked TLR. In those macrophages, the movement of LC3 to phagosomes in response to zymosan ingestion was significantly slowed. This suggested that TLR was required for triggering movement of LC3 to the phagosome, Green said.

The team also showed that two proteins critical for autophagy, ATG5 and ATG7, were key to the ability of macrophages to enable phagosomes to mature. For example, macrophages lacking ATG5 were not able to fuse phagosomes with lysosomes. While macrophages lacking ATG7 were able to phagocytize live yeast cells, the yeast were more likely to survive degradation in macrophages without ATG7 than yeast ingested by normal macrophages. This indicated that ATG7, a protein scientists thought was exclusively associated with autophagy, also participates in the destruction of pathogens internalized by phagocytosis.

This strongly suggested that TLR recruits parts of the autophagy machinery to enable the phagosome to fully develop and fuse with the lysosome even if autophagy itself doesnt occur simultaneously, Green said.

We can actually see phagocytosis take place in live cells and we can study it in detail, so we know the steps involved, said Miguel Sanjuan, Ph.D., a staff scientist in Greens laboratory. But autophagy seems to occur suddenly and we know about it only after its very obviously underway. Now that we discovered that phagocytosis uses some of the same biochemical signals as autophagy does, we can use that information to solve the mystery of how autophagy works. We hope that we will be able to translate that new knowledge in the future into improved treatments for infections and cancer.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. MRI finds breast cancer before it becomes dangerous
3. RAND finds cases of undiagnosed diabetes drop sharply
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. Ability to cope with stress can increase good cholesterol in older white men, study finds
6. Pitt study finds inequality in tobacco advertising
7. Study finds some kids are being misdiagnosed with asthma
8. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
9. Parents perceptions can hamper kids asthma care, study finds
10. Study finds primary care depression treatment often does not follow quality guidelines
11. Study of Studies Finds No Risk to Children From Phthalates in Toys
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... The MedTech industry is gearing up for new ... of PartnerTech AB of Sweden, is prepared to facilitate the ... Certification. , All signs point to growth in the MedTech ... a repeal of the excise tax originally levied to fund ... annual growth of 9.3% and PartnerTech Inc. is prepared to ...
(Date:12/22/2014)... 7,178 small business owners and marketing professionals ... and opted instead to join Digital Marketer, an Austin, ... 5th annual “Black Friday Boot Camp”. , ... the 5 hour online training event and raised $50,000 ... two Central Texas based charities dedicated to fighting childhood ...
(Date:12/22/2014)... 22, 2014 Christmas is days away, and ... fast and easy solution that will please: the Sublime ... purchased from from $25 up to $350," says Kathy Heshelow, ... satisfaction and a wide array of skin care products and ... no expiration dates. , Gift delivery past shipping deadlines, ...
(Date:12/22/2014)... A substantial percentage of patients ... (CT) to evaluate abnormal findings on outpatient chest ... to a new study published online in the ... show that radiologist recommendations for additional imaging (RAIs) ... care. , RAIs, which have grown 200 percent ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Parker & ... absolute best in Arizona home contracting services reports a ... to its quality services in 2014. As a company ... the early 1970s, Parker and Sons is a business ... The company works side-by-side with other top quality companies ...
Breaking Medicine News(10 mins):Health News:PartnerTech Inc. Poised for Growth in MedTech 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 3
... Mich. Can a grape-enriched diet prevent the downhill sequence ... , A University of Michigan Cardiovascular Center study suggests grapes ... impact that can come from a diet rich in fruits ... phytochemicals naturally occurring antioxidants turning on a protective ...
... Sabertec , an emerging environmental technology company ... designed to reduce CO2 emissions and toxic particulate ... efficiency, took part in a press conference on Tuesday, April ... Harrington .At the press conference, the mayor announced that ...
... Early Detection and Treatment of Lyme is ImperativeNEW YORK, April ... charity dedicated to Lyme disease research and healthcare provider education, ... New York Stock Exchange closing bell on April 23, 2009. ... to the start of LDAM to reinforce the importance of ...
... of the uninsured , , WEDNESDAY, April 22 (HealthDay News) -- ... period of time is greater today than it was two ... in coverage, however, are shorter than they used to be ... Medicaid. , "The bad news is the continuing reduction of ...
... Va., April 22 The National Alliance on Mental ... www.nami.org/soloist , as part of a social ... 24) of The Soloist, starring Jamie Foxx and Robert ... with schizophrenia and are homeless," said NAMI executive director ...
... Halo Pharmaceutical, this week announced that it ... The Provident Bank to expand its operations.Headquartered ... full-service, specialty pharmaceutical company. Halo provides state-of-the-art ... laboratory services to the pharmaceutical and related ...
Cached Medicine News:Health News:Benefit of grapes may be more than skin deep 2Health News:Benefit of grapes may be more than skin deep 3Health News:Brockton Mayor, James E. Harrington Calls Press Conference to Unveil Newly Adopted Auto Emissions Technology Acquired With Federal Stimulus Money 2Health News:Brockton Mayor, James E. Harrington Calls Press Conference to Unveil Newly Adopted Auto Emissions Technology Acquired With Federal Stimulus Money 3Health News:Turn the Corner Foundation Rings in Lyme Disease Awareness Month Early at NYSE on April 23, 2009 2Health News:Turn the Corner Foundation Rings in Lyme Disease Awareness Month Early at NYSE on April 23, 2009 3Health News:Turn the Corner Foundation Rings in Lyme Disease Awareness Month Early at NYSE on April 23, 2009 4Health News:More Americans Experiencing Gaps in Health Coverage 2Health News:More Americans Experiencing Gaps in Health Coverage 3Health News:The Soloist: A Call to Action 2Health News:Halo Pharmaceutical Completes $14.6 Million in Financing from The Provident Bank 2
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 ... ;  Sorrento), an oncology company developing new treatments ... a privately-held immuno-oncology company developing proprietary Neukoplast ® ... therapy, announced today that the companies have entered ... generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the ...
(Date:12/19/2014)... 18, 2014 Somewhere between dropping five pounds ... forgotten. But Audicus , a next-generation hearing aids ... new year. Hearing loss is the third ... though it is often unaddressed. Forty-eight million Americans have ... hearing aid, mainly due to price. Hearing aids traditionally ...
(Date:12/19/2014)... Dec. 18, 2014  Sage Analytics ( www.sageanalytics.com ... equipment for the testing of marijuana potency and ... new Luminary™ Profiler, the industry,s first product suite ... a cost-effective, portable unit. Designed from ... of the cannabis industry, the Luminary™ Profiler utilizes ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Audicus Will Help People Resolve to Hear Better in 2015 2Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... Holdings, Inc., (NYSE: HRC ) invites you ... Suisse,s 2011 Healthcare Conference in Phoenix on November 9, ... invited to listen to the live discussion via the ... directly at http://cc.talkpoint.com/cred001/110911a_ah/?entity=1_CIKQF3F .  A recorded replay of ...
... Epilepsy Therapy Project (ETP), a non-profit organization whose mission ... epilepsy and seizures and the parent organization of epilepsy.com, ... inviting entries that represent the most innovative ideas in ... Shark Tank competition will receive national recognition and a ...
Cached Medicine Technology:Epilepsy Therapy Project Announces "Shark Tank" Competition to Identify the Most Innovative, New Products for People with Epilepsy 2Epilepsy Therapy Project Announces "Shark Tank" Competition to Identify the Most Innovative, New Products for People with Epilepsy 3
... is the first truely web-based solution on the ... POC (managed from the lab) and Critical Care ... of AegisPOC ensures that all groups have the ... in the manner best suited to them. Through ...
... ultrasonic technology. When managing glaucoma patients and ... to use the best technology available. ... analog and digital technology that utilizes ultrasound ... other ultrasonic pachymeters in the market. This ...
...
...
Medicine Products: