Navigation Links
St. Jude finds 'dancing' hair cells are key to humans' acute hearing
Date:5/7/2008

Zuo is the senior author of a report on this work that appears in the May 8 issue of the journal Neuron.

Since the prestin protein is the key component of somatic motility, in previous experiments Zuo and his colleagues genetically knocked out prestin in mice and tested the effects on hearing. Those mice showed a hearing defect that indicated a malfunction of somatic motility. While the knockout experiments were strong evidence for the role of somatic motility, the affected mice also showed structural abnormalities in their outer hair cells, Zuo said, thus complicating the interpretation.

In the new experiments to more unequivocally establish the role of somatic motility, the researchers genetically altered mice to have only subtle alterations in the prestin protein. These alterations only compromised prestins function as an amplifier but did not otherwise affect the outer hair cell structure or function, the researchers analysis showed.

We found that these mice showed exactly the same kinds of hearing deficiency as the previous knockout mice, Zuo said. Therefore, we believe that these experiments eliminate criticism of our earlier experiments with the knockout mice. The new experiments, Zuo said, thus firmly establish that the dancing somatic motility of the outer hair cells is critical to cochlear amplification.

However, he noted, With this study we still cannot really exclude stereociliary motility from contributing to cochlear amplification, because eliminating somatic motility also reduces ciliary motility. So, it is not possible to totally isolate either form of motility. In fact, we hypothesize that the two mechanisms might work together in different aspects of amplification.

By finding prestins role in hearing Zuo and his colleagues may help scientists better understand the mechanisms of hearing loss. For example, an overdose of aspirin causes a high-frequency hearing loss by inhibiting prestins function, Zuo sa
'/>"/>

Contact: Carrie Strehlau
media@stjude.org
901-495-3306
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. MRI finds breast cancer before it becomes dangerous
3. RAND finds cases of undiagnosed diabetes drop sharply
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. Ability to cope with stress can increase good cholesterol in older white men, study finds
6. Pitt study finds inequality in tobacco advertising
7. Study finds some kids are being misdiagnosed with asthma
8. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
9. Parents perceptions can hamper kids asthma care, study finds
10. Study finds primary care depression treatment often does not follow quality guidelines
11. Study of Studies Finds No Risk to Children From Phthalates in Toys
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- The risk of ... holidays, so you need to be extra cautious, an ... we see a significant increase in patients coming in ... the Suffolk County Volunteer Firefighters Burn Center of Stony ... should be full of joy, but if not careful, ...
(Date:12/25/2014)... Dennis Thompson HealthDay ... Researchers could be closing in on a "fountain of youth" ... the health of older adults, a new study suggests. ... given a drug that targets a genetic signaling pathway linked ... Novartis report. The experimental medication, a version ...
(Date:12/25/2014)... “ SmileStix ” was featured on NewsWatch ... and coolest mobile applications on the iOS, Android, and Windows ... NewsWatch, conducted the app review and shared with viewers how ... , The old saying goes, “A picture says a thousand ... can describe a single image, because each picture holds a ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... Milestone in Program to Help Local Producers Grow ... Texas, May 26 Whole Foods Market (Nasdaq: ... organic foods supermarket, announced today that its Local ... United States with $2.5 million in low-interest loans.Whole ...
... 12 times more likely to suffer serious injury, study finds ... million Americans over age 40 have some form of inner-ear ... times more likely to suffer a serious fall, a new ... are unaware of their risk, mostly because they,ve had no ...
... 26, 2009 Babies of East Asian and South Asian ... be misclassified as underweight at birth when compared to their ... Hospital physician Dr. Joel Ray. Dr. Ray and a team ... for these ethnic groups, suggest the need to consider differences ...
... A short, preoperative team briefing prior to cardiac surgery ... improves communication and reduces errors and costs, according to ... researchers believe this is the first such study to ... briefings on specific disruptions to surgery. Disruptions were categorized ...
... May 26 Americans United for Life ... President Barack Obama nominating Sonia Sotomayor to replace Justice ... the President,s talk of finding ,common ground, this appointment ... judicial philosophy undermines common ground. She is a ...
... First Women,s Center of Homestead ORLANDO, Fla., May 26 ... newest restaurant at 2531 NE 8th Street in Homestead, ... Steakhouse to open in Florida and the seventh in ... pre-opening training period, the restaurant recently hosted a Friends ...
Cached Medicine News:Health News:Whole Foods Market(R) Lends $2.5 Million to Local Growers, Producers and Food Artisans 2Health News:Whole Foods Market(R) Lends $2.5 Million to Local Growers, Producers and Food Artisans 3Health News:Inner Ear Dysfunction Puts Older Adults at Risk of Falls 2Health News:Newborns of South Asian and East Asian descent misclassified as underweight at birth: Study 2Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 2Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 3Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 4Health News:LongHorn Steakhouse Brings the Spirit of the West to Homestead 2
(Date:12/24/2014)... and FARMINGTON, Conn. , ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of 2,050,000 shares of its common ... shares of its common stock.  Funds under the ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... CHAPEL HILL, N.C., Dec. 17, 2010 The oncology ... by many organizations in the bio-pharmaceutical sector. It,s in ... are scrutinizing their strategies and tactics to support market ... successful launch, it,s critical that companies inform thought leaders, ...
... the growing cholera epidemic in Haiti, the American Red ... the Pan American Health Organization (PAHO) to purchase, ship, ... (Logo: http://photos.prnewswire.com/prnh/20090108/RedCrossLOGO ) ... in Haiti has now exceeded 100,000. Funds will provide ...
Cached Medicine Technology:Research from Best Practices, LLC Delivers Effective Market Education Tactics and Strategies for New Oncology Products 2Red Cross Supports Pan American Health Organization with $1.5 Million in Medicine and Supplies for Cholera Response 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: