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St. Jude finds anti-leukemia drug increases patient fatigue
Date:11/2/2007

The anti-leukemia drug dexamethasone contributes to a relentless fatigue and poor quality of sleep in children undergoing treatment for acute lymphoblastic leukemia (ALL), according to a new study from St. Jude Children's Research Hospital. The finding suggests that clinicians could improve the quality of life for these children by developing new methods of drug administration that reduce or eliminate these side effects.

The St. Jude team showed that dexamethasone significantly increased patients?fatigue, length of daytime naps, frequency of awakening at night and the amount of restlessness during sleep. The findings also suggest that before initiation of continuation therapy for ALL, health care workers should prepare patients and families to expect an increase in disrupted sleep and fatigue during dexamethasone treatment. Continuation therapy is the long-term treatment that occurs following the initial intensive use of anti-cancer drugs designed to quickly reduce the number of cancer cells.

Parents and patients have long reported altered behaviors during dexamethasone treatment, but this is the first trial to document that disrupted sleep and fatigue are behavioral indicators of patients?response to the treatment,?said Pamela Hinds, Ph.D., R.N., director of the Division of Nursing Research at St. Jude. Hinds is the first author of this study, which appears in the online version of the journal Cancer.?

Previous studies had found that dexamethasone was especially effective in the treatment of ALL, but that it could also cause a variety of side effects in children, including fatigue. Therefore, the St. Jude team designed the current study to determine if the direct and consistent link between dexamenthasone and fatigue and disrupted sleep in children was significant and common.

Before we could begin to revise the way we give dexamethasone to children we had to establish if the drug routinely disrupts the sleep of children, o
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Contact: Carrie Strehlau
media@stjude.org
901-495-2295
St. Jude Children's Research Hospital
Source:Eurekalert

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