Navigation Links
St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease
Date:7/7/2008

o engage in lysosomal exocytosis into the bone marrow environment.

"The evidence strongly suggests that in children lacking a normal gene for NEU1, disruption of the bone marrow environment causes the exodus of hematopoietic cells from the marrow to the spleen," d'Azzo said. "That leads to development of the symptoms of sialidosis. Although we don't have a cure for this terrible disease, we are now beginning to identify alternative ways to improve the disease outcome in affected children."

These findings offer new insight into why bone marrow transplants do not work in humans who lack the neu1 gene, d'Azzo said. Bone marrow cells transplanted into patients should normally home in the bone marrow niche and stay there until they mature. But if the bone marrow environment is hostile because of the loss of NEU1, the donated stem cells migrate out of the marrow and the transplant fails.

"The exciting thing about this work is that it sheds light on two major issues: the cause of sialidosis and the reason for bone marrow transplantation failure in the absence of NEU1," d'Azzo said. "This wealth of new information gives us a better understanding of the physiological function of NEU1, which appears to be much broader than originally thought. This illustrates the important role of basic research in making discoveries that have major implications for medical problems."

Other authors of this paper include Erik Bonten, Diantha van de Viekkert, Huimin Hu, Simon Moshiach and Samuel Connell (St. Jude) and Gouri Yogalingam (formerly of St. Jude).

This work was supported by the National Institutes of Health, the Assisi Foundation of Memphis and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jud
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. 98% of Elective Mastectomy Patients Would Have Reconstruction Again, Says ASPS Study
2. 98 percent of elective mastectomy patients would have reconstruction again, says ASPS study
3. MDS Pharma Services Launches Next Generation Phase I Study Management System
4. Geisinger study: PTSD causes early death from heart disease
5. Aggressive treatment of childhood eczema could help prevent asthma, says new study
6. New study finds coronary arterial calcium scans help detect overall death risk in the elderly
7. Study: 9/11 Dogs Suffered Few Health Effects
8. Penn animal study identifies new DNA weapon against avian flu
9. Researcher receives $4 million from RWJ Foundation to study health quality reform project
10. NYU, Rutgers study shows how using mental strategies can alter the brains reward circuitry
11. Researchers study hidden homicide trend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... New York, New York (PRWEB) May 24, 2015 ... of testosterone treatment lawsuits ( http://www.testosteronelawsuithub.com/ ) has ... discuss the progress of the multidistrict litigation. According ... Court, Northern District of Illinois, the Conference will ... p.m. (In re: Testosterone Replacement Therapy Product Liability ...
(Date:5/24/2015)... Scottsdale, Arizona (PRWEB) May 24, 2015 ... hired former Millennial Media strategy executive Jay Krihak ... as Medicx looks to ramp up its expertise ... services of the Pharmaceutical and Health sectors. , ... ad tech executive. Most recently, Krihak led sales ...
(Date:5/23/2015)... FL (PRWEB) May 23, 2015 On Saturday, ... build a new playground for Branches Florida City exactly five ... former play space in 2010. , A large fire tore ... playground on May 23, 2010 in the middle of the ... The fire was later declared arson even though it is ...
(Date:5/23/2015)... CA (PRWEB) May 23, 2015 With ... small businesses, are finding it increasingly difficult to provide ... which fail to provide adequate insurance for employees stand ... businesses been such an integral part of a business’s ... affordable healthcare for businesses, Online USA Doctors has created ...
(Date:5/23/2015)... Manufacturers are now required to produce water heaters ... Experts in the field agree that the regulation is aimed ... score is what miles per gallon is to your car. ... the minimum HSPF score has been raised to 8.2, technology ... north of 12. Indeed, the regulation was welcomed by environmentalist, ...
Breaking Medicine News(10 mins):Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 3Health News:Medicx Media Solutions Expands Executive Team 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2
... Genetic Testing IndustryWALTHAM, Mass., Feb. 2 Interleukin ... that Chief Executive Officer Lewis H. Bender will ... Financial Strategies for Molecular Diagnostics conference, taking place ... presentation is scheduled for Wednesday, February 4 at ...
... Ask for Provisions in Stimulus Package to Help ... than 57,000 new jobs, 26,800 of which will ... in the United States through the Renewable ... to Congress and the Administration by Health Care ...
... 2 AMDL, Inc. (NYSE,Alternext US: ADL), a vertically ... announced today its Chairman and CEO Mr.,Douglas MacLellan will ... (3:40 a.m.,PT) today, February 2, 2009. , ... expert on Fox Business News to,discuss the current business ...
... to Florida to Open its Doors, with Ceremonies at 103,000-Square-Foot Facility ... ... 2009 -- More than 200 community, government and science leaders celebrated ... Studies, (TPIMS) headquarters in the Florida Center for Innovation at ...
... Network" to serve Healthcare Industry , ... ... Marketing Solutions LLC today announced partnerships with several leading ... MindSet,s geoMEDICX Zip+4 and Zip code targeting tags and offer ...
... ... Denver, CO (PRWEB) February 2, 2009 -- Susan Cordts, ... in an exclusive interview with Mary Jo Nott and the BeyeNETWORK ... predict who to target with what product, identifying what media with ...
Cached Medicine News:Health News:Interleukin Genetics to Present at G-2 Reports' Molecular Diagnostic Conference 2Health News:Healthcare Sector Leaders Urge Obama, Congress to Invest in Alternative Energy and Green Jobs in Healthcare 2Health News:Healthcare Sector Leaders Urge Obama, Congress to Invest in Alternative Energy and Green Jobs in Healthcare 3Health News:AMDL Chairman & CEO Mr. Douglas MacLellan Featured on Fox Business News Monday February 2, 2009 2Health News:Torrey Pines Institute for Molecular Studies Opens New Headquarters in Florida 2Health News:Torrey Pines Institute for Molecular Studies Opens New Headquarters in Florida 3Health News:Mindset Marketing Solutions Partners with Platform-A, ValueClick Media, AdRX Media, Datran Media and Morefocus Media 2Health News:Mindset Marketing Solutions Partners with Platform-A, ValueClick Media, AdRX Media, Datran Media and Morefocus Media 3Health News:ATi Tailored BI and Advanced Predictive Analytics Solutions Improve Marketing Response Rates 2Health News:ATi Tailored BI and Advanced Predictive Analytics Solutions Improve Marketing Response Rates 3
(Date:5/22/2015)... THOUSAND OAKS, Calif. , May 22, ... today announced the Company has commenced termination ... commercialization of brodalumab with AstraZeneca (LON:AZN, STO:AZN ... investigational IL-17 inhibitor, is in development for ... and axial spondyloarthritis.  The decision was based ...
(Date:5/22/2015)... OTTAWA , May 22, 2015 /CNW/ - More than ... prescribed to treat morning sickness in expectant mothers. Tragically, Thalidomide ... children and families. Support has been provided ... the Government of Canada in 1991 ... the absence of a legal obligation to provide support, we ...
(Date:5/22/2015)... 22, 2015  BioLife Solutions, Inc. (NASDAQ: BLFS ), ... hypothermic storage and cryopreservation freeze media ... tissues ("BioLife" or the "Company"), announced that the Company is ... The Company is scheduled to present at the ... at the Grand Hyatt Hotel in New York ...
Breaking Medicine Technology:Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5Statement from Minister Ambrose on Thalidomide 2Statement from Minister Ambrose on Thalidomide 3BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2
... Porous Technologies, a developer and manufacturer of custom fluid-handling ... introduce a new range of hydrophilic, polyurethane foams for ... trade fair in Dusseldorf, Germany from 16 to 18 ... New innovations to be featured at the ...
... Texas, Nov. 2, 2011 Novation commends the White ... facing America,s hospitals through its October 31st Executive Order. ... support of the bipartisan legislation – (S. 296 and ... to establish a framework by which the quality and ...
Cached Medicine Technology:Filtrona Porous Technologies to Introduce New Hydrophilic Foam Products for Advanced Wound Care at the MEDICA / COMPAMED Trade Fair 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: