Navigation Links
St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease
Date:7/7/2008

eded products into small building blocks that the cell can reuse or dispose.

The St. Jude team found that in the absence of NEU1, white cell lysosomes are more prone than normal lysosomes to dock and eventually fuse with the cell membrane and subsequently spill their active enzymes into the bone marrow environment. This aberrant behavior hampers the ability of hematopoietic stem cells (HSCs) to be correctly retained within the bone niche. HSCs are immature cells that give rise to all the types of blood cells in the body. The researchers showed that the released enzymes prematurely digest a protein on bone marrow stromal cells called VCAM-1, a molecule that these cells use to hold onto HSCs in the bone marrow.

Deprived of their normal nurturing environment, the HSCs migrate out of the bone marrow and into the spleen, crowding into the organ until it becomes severely enlarged. "Our work represents an unexpected and important clue to one of the prominent clinical manifestations of sialidosis patients," d'Azzo said. "We were surprised to discover that an old, ubiquitous enzyme in lysosomes better known for digesting cellular waste products plays such an important role in a basic biological process that when exacerbated contributes to the outcome of such a terrible disease in children."

In a series of experiments, d'Azzo's team discovered that the way NEU1 regulates the pool of lysosomes destined for lysosomal exocytosis is by cutting off a sugar called sialic acid from a structural protein of the lysosomal membrane, known as LAMP-1. They found that LAMP-1 is involved in the docking of lysosomes at the cell membrane, a prerequisite for these organelles to fuse with the cell membrane and release their content outside the cell. When NEU1 strips the sialic acids off LAMP-1, this protein is rapidly turned over so that its total amount is reduced. Less LAMP-1 at the lysosomal membrane influences the capacity of lysosomes to dock at the cell membrane and t
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. 98% of Elective Mastectomy Patients Would Have Reconstruction Again, Says ASPS Study
2. 98 percent of elective mastectomy patients would have reconstruction again, says ASPS study
3. MDS Pharma Services Launches Next Generation Phase I Study Management System
4. Geisinger study: PTSD causes early death from heart disease
5. Aggressive treatment of childhood eczema could help prevent asthma, says new study
6. New study finds coronary arterial calcium scans help detect overall death risk in the elderly
7. Study: 9/11 Dogs Suffered Few Health Effects
8. Penn animal study identifies new DNA weapon against avian flu
9. Researcher receives $4 million from RWJ Foundation to study health quality reform project
10. NYU, Rutgers study shows how using mental strategies can alter the brains reward circuitry
11. Researchers study hidden homicide trend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... (EGFR) mutations found in the circulating free tumor DNA ... cancer (NSCLC) patients correlates well with the EGFR mutations ... inhibitor (TKI) therapy is approved for EGFR activating mutation ... determining mutation status is with DNA derived directly from ... A more abundant and less invasive source of tumor ...
(Date:8/22/2014)... DC (PRWEB) August 22, 2014 Paying ... little easier in the coming year for four nurse ... the National League for Nursing Foundation for Nursing ... – will share $28,000, $10,000 more than in 2013, ... Ann Kerr Endowment and Elizabeth Isaac Marcil Endowment Funds, ...
(Date:8/22/2014)... August 22, 2014 Advancements in ... some clinical applications due to their cost-effectiveness, non-invasiveness, ... innovations in ultrasound, such as the evolution of ... to keep the market moving throughout 2014 and ... can enhance not only the point-of-care (POC) testing ...
(Date:8/22/2014)... Eagerly embracing intended parents around the ... now offers the top male infertility programs — run ... fertility network of IVFinMexico.com continues to shape ... care, female and male infertility, advanced research and education. ... so eminently set by company CEO and Founder Tolga ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 CarePoint ... specialist in Internal Medicine, Geriatrics, Hospice and Palliative ... CarePoint Health Medical Group. Their system welcomes Dr. ... and experienced physicians comprise CarePoint Health Medical Group, ... in Hudson County, representing a wide range of ...
Breaking Medicine News(10 mins):Health News:High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 3Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:Dr. Reisner Joins CarePoint Health Medical Group 2
... ReBuilder Medical,Technologies, Inc. (Pink Sheets: RBRM), announces ... ), "We have leased, fitted and established ... will allow us to streamline the process,of new ... facility will house,both electronic and pharmaceutical laboratories," announced ...
... &, Presidential Election May Mean for Private Equity in 2008, Jan. ... the ... credit markets in,turmoil, the economy in a seeming slowdown and a presidential ... Outlook,Conference on January 29-30 at the Grand Hyatt in New York to ...
... men with chronic anxiety are at substantially higher risk, experts ... who suffer from chronic anxiety substantially increase their risk of ... stress has been linked to an increased risk of heart ... been identified as a risk factor also. , "There is ...
... 2 diabetes are often advised to cut out sucrose (table ... has been questioned by some researchers who suggest that moderate ... the diet of patients with diabetes. Now a new study ... It showed that patients who increased their daily sugar intake ...
... tendon grafts loaded with gene therapy may soon ... that has eluded surgeons to date. According to ... Therapy, a new graft technique may provide the ... can reorganize as it heals. Such tissue-engineering approaches ...
... Haemonetics,Corporation (NYSE: HAE ) will announce its Q3FY08 earnings on January ... Conference Call Dial-In Information (888) 802-8577 ... ID: 30405896 This call will be ... dial:, (800) 642-1687 (US & Canada) ...
Cached Medicine News:Health News:ReBuilder Medical Technologies, Inc. Expands R&D of New Products 2Health News:Private Equity's Top Execs to Share Advice, Candid Predictions at 2008 Outlook Conference 2Health News:Anxiety Raises Heart Attack Risk 2Health News:Anxiety Raises Heart Attack Risk 3Health News:Carrot cake study on sugar in type 2 diabetes 2Health News:Freeze-dried tendon implants prove effective in early studies 2Health News:Freeze-dried tendon implants prove effective in early studies 3Health News:Freeze-dried tendon implants prove effective in early studies 4Health News:Freeze-dried tendon implants prove effective in early studies 5
(Date:8/22/2014)... Aug. 22, 2014 /CNW/ - On Aug. 20, at ... the Canadian Medical Association (CMA) voted on and approved ... material, including medicinal cannabis. Bedrocan Cannabis Corp., a leading ... the CMA motion. The CMA is quite ... associated with smoking any plant material, including medicinal cannabis. ...
(Date:8/22/2014)... CHICAGO , Aug. 22, 2014   Zacks Equity Research ... the Bull of the Day and Panera (Nasdaq: PNRA - ... Zacks Equity Research provides analysis on Amicus Therapeutics (Nasdaq: FOLD ... ) and Shire (Nasdaq: SHPG - Free Report ). ... Bull of the Day : The ...
(Date:8/22/2014)... COLORADO SPRINGS, Colo. , Aug. 22, 2014 ... Company specializing in cannabis formulation-based drug development and ... of UFCM iCare,s third international medical cannabis conference ... Strasbourg, France , on October ... experts with other stakeholders, such as researchers, health ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... 22, 2011 ResearchDx announced today the official ... CDO. Recent FDA initiatives, such ... Co-Development Concept Paper, have spurred biopharmaceutical companies, interest ... companion diagnostics. The traditional Contract Research Organization (CRO), ...
... OMER ) today announced that its exclusive license to ... been amended to include addiction and compulsive disorders in the ... Company,s discovery of a previously unknown link between PDE7 and ... it also is the first to link PDE7 to any ...
Cached Medicine Technology:ResearchDx Launches Contract Diagnostics Organization (CDO) 2Omeros Announces Expansion of Exclusive License to PDE7 Inhibitors from Daiichi Sankyo 2Omeros Announces Expansion of Exclusive License to PDE7 Inhibitors from Daiichi Sankyo 3Omeros Announces Expansion of Exclusive License to PDE7 Inhibitors from Daiichi Sankyo 4
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... The Research pro Electronic Pipette is ideal ... laboratory. Its easy-to-follow display, ergonomically-placed operating buttons, ... dispensing, reverse pipetting and diluting make this ... simple functions of a manual pipette without ...
... a 384 Well Plate at Once , To ... you need a pipettor that can adapt to ... get with our 16-channel Impact pipettor., Available with ... was specifically designed to allow you to transfer ...
Medicine Products: