Navigation Links
St. Jude Researchers Identify Key Genetic Trigger of Acute Myeloid Leukemia
Date:11/27/2007

several other proteins that normally cooperate to prevent apoptosis -- a known effect of the protein made by N-Myc, Grosveld said.

The researchers then showed that mice that received bone marrow cells that were genetically engineered to overexpress N-Myc developed AML and died within 50 days.

Finally, Grosveld's team showed that the transformation of a myeloid cell to a leukemic cell requires overexpression of Twist, a gene that normally inhibits apoptosis.

"This work demonstrates the critical role N-Myc plays in AML and maps out the cooperation with other genes that blunt N-Myc's apoptotic effects, thereby tipping the delicate balance between cell death and cancer," Grosveld said.

Other authors of this report include Hiroyuki Kawagoe, Ayten Kandilci and Tanya Kranenburg (St. Jude).

This work was supported by the National Cancer Institute, a Cancer Center Support Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


'/>"/>
SOURCE St. Jude Children's Research Hospital
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... A large influx of international aid is needed, and ... thousands of deaths from the widening Ebola crisis, a ... a specially designed mathematical model, the researchers looked at ... densely populated county of hard-hit Liberia -- Montserrado County, ... researchers said that if international aid isn,t delivered to ...
(Date:10/25/2014)... By Randy Dotinga ... -- As more genetic tests are developed that spot increased ... would be more proactive about getting screened. But a ... does not change behavior: People who found out their genes ... than people with average risk to get screened. "It ...
(Date:10/22/2014)... 2014 At a time when the ... and athletes at all levels, the UPMC Sports ... current discussion where two powerful messages are lost: Concussions ... result in full recoveries every day. , In striving ... fact and research, UPMC and the Concussion Program are ...
(Date:10/22/2014)... On October 22, CBS will air an ... both fictional and real. The Charles E Holman ... to advocacy and philanthropy in the battle against Morgellons ... to impart truth and clarity about this misunderstood and ... misconceptions about Morgellons Disease (MD) and most ...
(Date:10/22/2014)... Isabel Healthcare will participate in ... Conference on October 22-24 in Las Vegas, NV. Jason ... panel discussion on Technology in Health Professions Education – ... diagnostic decision support tool and clinical education platform designed ... and clinical learners. The Isabel tools help clinicians broaden ...
Breaking Medicine News(10 mins):Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:Knowing Genetic Risk for Cancer May Not Change Behavior 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2
... schoolgirls in Texas must be vaccinated against the sexually transmitted ... to require the shots. ,The girls will have ... the human papillomavirus, or HPV, that are responsible for most ... efforts to pass laws in state legislatures across the country ...
... has continued to decrease since the early 1990s, the rate ... percent higher in African American women than in white men ... ,However, the disparity among men has narrowed over ... African Americans than whites. These data appear in the newly ...
... Prince George, Canada are down with food poisoning after a ... of the school’s// weekly hot lunch program. ,Incidentally ... authorities got concerned when an unusual number of parents phoned ... ,School authorities immediately notified the Northern Health authorities ...
... an ‘all clear’ report after a breast scan, has ... eyebrows in the medical community and caused outrage among// ... the breast scan. ,Consultant radiologist Amjad ... been suspended and is going through a General Medical ...
... Instead of dismissing grumblings about being tired or exhausted, ... to a worsened health state or even death, says ... ,Dr. Karin Olson, a U of A professor from ... between tiredness, fatigue and exhaustion and that recognizing those ...
... study has found that a brief session of muscle-building exercise ... response.// ,The immune system’s reaction differs markedly between ... process remains unclear. ,“We’re trying to find ... benefit your vaccine response,” said lead author Kate Edwards, Ph.D., ...
Cached Medicine News:Health News:Cancer Death Rates High in African-Americans 2Health News:Take Fatigue Seriously - Says Researcher 2Health News:Take Fatigue Seriously - Says Researcher 3Health News:Muscle-Building Exercise Improves Response to Flu Shot 2
(Date:10/25/2014)... 24, 2014 ... announced the addition of the  "Global and ...  report to their offering.       ... Acne Medication Industry Report 2014 is a ... state of the global acne medication industry ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
(Date:10/22/2014)... 22, 2014  Medical Diagnostic Laboratories, L.L.C., ... in high complexity, state-of-the-art, automated DNA-based molecular ... new Cystic Fibrosis Testing which utilizes cutting ... platforms. Cystic fibrosis (CF), or ... that affects the respiratory, gastrointestinal and reproductive ...
Breaking Medicine Technology:Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3Strong Participation in Best Practices' Medical Affairs Consortium Survey 2Medical Diagnostic Laboratories, L.L.C. Institute for Biomarker Research Announces New Prenatal Cystic Fibrosis Tests 2
... Merit Medical Systems, Inc. (NASDAQ: MMSI ... medical devices used in interventional and diagnostic procedures, particularly ... Company will release its financial results for the third ... the stock market on Tuesday, October 25th, 2011. ...
... Md., Oct. 11, 2011 Christine K. Pierre, president ... "Professional Woman of the Year" by the National Association ... Pierre,s "outstanding leadership and commitment" within her profession, according ... Pierre founded RxTrials, Inc., in 1994, and ...
Cached Medicine Technology:Christine Pierre Selected as "Professional Woman of the Year" 2
... MediCopia is a system for inpatient caregiving ... automated computer system offers four technologies in ... a handheld computer (for work order processing), ... thermal printer (for label generation at bedside) ...
The Metrologic MS9520 Voyager is a high performance single line laser bar code scanner with automatic activation and sophisticated data transmission via Metrologic proprietary CodeGate technology....
... wristband that provides automated ID verification for ... efficiency and accuracy. Meets healthcare patient ID ... risk of data left on ribbons (HIPAA) ... (FDA). Also available with UV varnish, which ...
... Laser Sheeted Wristband / ... laser-printable sheets with an ... laser labels that adhere ... clear, fold-over protective window ...
Medicine Products: