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St. Jude Researchers Identify Key Genetic Trigger of Acute Myeloid Leukemia
Date:11/27/2007

several other proteins that normally cooperate to prevent apoptosis -- a known effect of the protein made by N-Myc, Grosveld said.

The researchers then showed that mice that received bone marrow cells that were genetically engineered to overexpress N-Myc developed AML and died within 50 days.

Finally, Grosveld's team showed that the transformation of a myeloid cell to a leukemic cell requires overexpression of Twist, a gene that normally inhibits apoptosis.

"This work demonstrates the critical role N-Myc plays in AML and maps out the cooperation with other genes that blunt N-Myc's apoptotic effects, thereby tipping the delicate balance between cell death and cancer," Grosveld said.

Other authors of this report include Hiroyuki Kawagoe, Ayten Kandilci and Tanya Kranenburg (St. Jude).

This work was supported by the National Cancer Institute, a Cancer Center Support Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


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SOURCE St. Jude Children's Research Hospital
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