Navigation Links
St. Jude Researchers Identify Key Genetic Trigger of Acute Myeloid Leukemia
Date:11/27/2007

N-Myc gene lives a double life, triggering cancer when it works with the growth-promoting protein IL-3 and causing cell suicide in the absence of IL-3

MEMPHIS, Tenn., Nov. 27 /PRNewswire-USNewswire/ -- A gene called N-Myc leads a double life in certain white blood cells when it is overexpressed, helping to trigger acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.

"Since N-Myc overexpression frequently occurs in human AML as well, this discovery gives researchers an important insight into N-Myc's role in human AML," said Gerard Grosveld, Ph.D., chair of the St. Jude Department of Genetics and Tumor Cell Biology. "It also might contribute to new strategies for treating this leukemia or disrupting this gene's ability to cause it." Grosveld is senior author of a report on this work that appears in the Nov. 15 issue of "Cancer Research."

The researchers showed that artificially forcing overexpression of N-Myc in bone marrow cells of mice strongly promotes AML; and that levels of N-Myc RNA (the decoded form of a gene) from 137 patients with AML were between two- and 33-fold higher than in normal bone marrow cells.

The team also showed that myeloid cells that were genetically engineered to overexpress N-Myc became immortalized, or had an unlimited life span, and that this was associated with changes in levels of certain proteins known to occur when human myeloid cells become leukemic.

The St. Jude team demonstrated in cell cultures that N-Myc can also trigger apoptosis and kill the cell instead of making it reproduce uncontrollably. Specifically, most myeloid cells over-expressing N-Myc died within 24 hours when they were deprived of an anti-apotosis, growth-promoting protein called IL-3. In addition, there was a significant decrease in the activity of
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... Representatives with Health Food ... its website. , “Our ‘Ask a Nutritionist’ feature on our website is a free ... said Liza Brisk, nutritionist and spokeswoman for Health Food Grocers. , Health Food Grocers’ ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... Journal Constitution, the new Lifetime reality series, “Atlanta Plastic” is getting attention for ... receives plastic surgery, with its predominantly African-American cast of doctors and patients. Beverly ...
(Date:8/3/2015)... , ... August 03, 2015 , ... ... of Appeals ruled in favor of the firm’s client Rebecca Hamsher, deciding that ... Medical Center must reimburse benefits for Hamsher’s residential treatment for bulimia, depression and ...
(Date:8/3/2015)... ... August 03, 2015 , ... Novation, the ... to offer pharmacogenetic lab testing and precision medicine solutions that can help pharmacists ... , Annually, more than 8.6 million adverse drug events are reported in the ...
(Date:8/3/2015)... CA (PRWEB) , ... August 03, 2015 , ... ... services to help patients in need. Most people know that general health emergencies, such ... Unfortunately, a fewer amount of people know where to turn to during a dental ...
Breaking Medicine News(10 mins):Health News:Health Food Grocers Launches "Ask a Nutritionist" Service 2Health News:Health Food Grocers Launches "Ask a Nutritionist" Service 3Health News:Article on Lifetime’s New “Atlanta Plastic” Reality Series Underlines the Diversity of Today’s Plastic Surgery Patients, Says Plastic Surgeon Dr. J 2Health News:Article on Lifetime’s New “Atlanta Plastic” Reality Series Underlines the Diversity of Today’s Plastic Surgery Patients, Says Plastic Surgeon Dr. J 3Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 2Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 3Health News:Novation Awards Genelex First Group Purchasing Agreement for Pharmacogenetic Testing and Precision Medicine Software 2Health News:Novation Awards Genelex First Group Purchasing Agreement for Pharmacogenetic Testing and Precision Medicine Software 3Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 2Health News:Los Angeles Dental Practice, Sunset Plaza Dental, Now Offers Emergency Dental Services 3
... ... with HCG Diet Drops , ... 14, 2010 -- It is no secret that obesity has reached epidemic proportions in our country. ... as a result of the extra pounds. , , ,But thanks to the HCG ...
... ... accident claims service National Accident Helpline warns of the dangers of cycling injuries and urges caution ... (PRWEB) June 14, ... to prevent cycling injuries now the improving weather is seeing an increasing number of people take ...
... ... the amazing true tale of one man,s journey of growing up in poverty ... a college degree. He decided to make a difference in the lives ... numerous local and national awards for his community work. He took his ...
... ... software is pleased to welcome Click2Scan Ltd. a document scanning specialist, and document management software ... ... Ltd. www.click2scan.co.uk with offices in Wiltshire and London is one of the fastest ...
... ... Jazz Festival, , ... Newport, R.I. (PRWEB) June 14, 2010 -- New Festival Productions today announced that discounted ... the 2010 CareFusion Newport Jazz Festival in Newport, RI, August 6-8. Generously donated by ...
... ... in cosmetic, facial plastic, and reconstructive surgery, understands that women need options. With an ... an alternative method to breast implant surgery. Natural breast augmentation allows patients the opportunity ... ...
Cached Medicine News:Health News:Thousands Drop The Weight For Good with HCG Diet Drops 2Health News:Break The Injury Cycle, Says National Accident Helpline 2Health News:Celebrated Father Overcame Poverty and Mental Illness to Help His Son Earn a Scholarship to Harvard 2Health News:FileHold Document Management Software welcomes Click2ScanLtd. as a Value Added Re-sellers in the UK 2Health News:CareFusion Newport Jazz Festival Discounts Tickets for Health Care Practitioners 2Health News:Del Mar Plastic Surgeon Dr. Maurice Sherman Now Offering Natural Breast Implant Alternatives 2
(Date:8/3/2015)...  Sage Analytics ( www.sageanalytics.com ), the developers of ... systems, announced its sponsorship of the California Cannabis Industry ... number of tickets are available for groups or individuals ... while enjoying an open bar, buffet dinner and hors ... Bay at sunset. With the legislative session ...
(Date:8/3/2015)...  Depomed, Inc. (NASDAQ: DEPO ) ("Depomed" or ... HZNP ) ("Horizon") announcement that it intends to ... a record date to determine the shareholders eligible to ... Board will review the request when it is received. ... the information required under Depomed,s bylaws, the Depomed Board ...
(Date:8/3/2015)... , August 3, 2015 ... by Persistence Market Research "Global Market Study on ... to Witness Highest Growth by 2022", the global physiotherapy ... Bn by the end of 2015 and is expected ... 2015 to 2022, to account for US$23.7 Bn by ...
Breaking Medicine Technology:Sage Analytics Sponsors California Cannabis Industry Association Bay Area Cruise FUNdraiser 2Depomed Comments on Horizon Pharma Announcement 2Depomed Comments on Horizon Pharma Announcement 3Depomed Comments on Horizon Pharma Announcement 4Depomed Comments on Horizon Pharma Announcement 5Depomed Comments on Horizon Pharma Announcement 6Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 2Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 3Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 4
... Aug. 24 GE Healthcare is proud to ... is now included in the company,s ecomagination(SM) campaign. ... contrast media, offers significant advantages over traditional glass ... healthcare workers who administer contrast media to patients, ...
... Aug. 24 Regenicin, Inc. ... biotechnology company, announced today that Dr. Joseph Rubinfeld, one of ... agreed to join the company,s board of directors. Dr. Rubinfeld ... PermaDerm™, Regenicin,s proprietary autologous cultured skin ...
Cached Medicine Technology:+PLUSPAK (polymer bottle) Packaging Receives GE's Distinguished ecomagination(SM) Approval 2+PLUSPAK (polymer bottle) Packaging Receives GE's Distinguished ecomagination(SM) Approval 3Regenicin Appoints Amgen Co-founder Dr. Joseph Rubinfeld to Board of Directors 2
Prognosis / Patient Management. HIV-1 Viral Load Assay. NucliSens HIV-1 QT covers the entire dynamic range of viral load testing from a single patient sample, without reflex testing or thermalcycli...
EIA for Donor Screening. Synthetic peptide Enzyme Immunoassay (EIA) for the detection of antibodies to Human Immunodeficiency Virus Types 1 and/or 2,(HIV-1 and HIV-2) in human serum, plasma or ca...
... OraQuick ADVANCE Rapid HIV-1/2 ... single-use, qualitative immunoassay to ... Immunodeficiency Virus Type 1 ... (HIV-2) in oral fluid, ...
... performance benefits of TiMAX material have been applied ... Greater strength and an ultra-low profile combine to ... the lower extremity. , ,This complete set of ... Plate , Fibula Composite Plate ...
Medicine Products: