Navigation Links
St. Jude Finds Mechanism for Faulty Protein Disposal
Date:12/6/2007

Discovery shows how a group of molecules pulls certain types of defective proteins out of the cell's protein factory, a finding that could help development of new cancer drugs

MEMPHIS, Tenn., Dec. 6 /PRNewswire-USNewswire/ -- A discovery by St. Jude Children's Research Hospital scientists offers new insights into how myeloma cells dispose of defective or excess proteins and could lead to new cancer treatments.

The researchers identified key cellular components that carry out protein disposal, a finding that helps to explain how cancer drugs called proteasome inhibitors interfere with this process. The discovery is important because the newly identified components of the protein disposal mechanism could be targets for novel cancer drugs designed to kill the cell by blocking disposal of defective proteins. A report on this work appears in the Nov. 30 issue of "Molecular Cell."

Myelomas are cancers of plasma cells, which are the "activated" form of B lymphocytes--immune system cells that respond to infection by temporarily producing extremely large amounts of proteins called antibodies that attack the target. The rapidly multiplying cancer cells continually make large numbers of new antibodies, which increases the chance for errors in the production process, resulting in the accumulation of defective proteins that must be degraded.

"Proteasome inhibitors are currently being used to treat some types of cancer including multiple myelomas, although many aspects of this cellular process remain poorly understood," said Linda Hendershot, Ph.D., a member of the St. Jude Department of Genetics and Tumor Cell Biology, and the paper's senior author.

"The results of our study help to explain how the process works and how we might design ways to block it in myelomas," said Yuki Okuda-Shimizu, Ph.D. a postdoctoral fellow in Hendershot's laboratory who contributed significantly to the project.

This work was supported by the National Institutes of Health, a Cancer Center Support Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


'/>"/>
SOURCE St. Jude Children's Research Hospital
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. MRI finds breast cancer before it becomes dangerous
3. RAND finds cases of undiagnosed diabetes drop sharply
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. Ability to cope with stress can increase good cholesterol in older white men, study finds
6. Pitt study finds inequality in tobacco advertising
7. Study finds some kids are being misdiagnosed with asthma
8. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
9. Parents perceptions can hamper kids asthma care, study finds
10. Study finds primary care depression treatment often does not follow quality guidelines
11. Study of Studies Finds No Risk to Children From Phthalates in Toys
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/16/2019)... ... 15, 2019 , ... As demand for legal medical marijuana ... well-managed dispensaries becomes more and more important, both for consumers and as part ... online, custom cannabis business plans is now increasing its support for marijuana dispensary ...
(Date:11/15/2019)... MIAMI (PRWEB) , ... November 15, 2019 , ... ... Anxiety and Depression Association of America (ADAA) puts the current figures ... any form of treatment. Such mental health issues manifest in many different ways, ...
(Date:11/15/2019)... (PRWEB) , ... November 15, 2019 , ... ... and co-builds next-generation cybersecurity and data science companies with nation-state experienced technical teams ... of its second-annual DataTribe Challenge is Code Dx Inc ., based in ...
(Date:11/14/2019)... ... ... Inland Detox, Inc. is proud of and grateful for its Chef, Arturo Banuelos, ... Mexico. The Chefs Latinos Guanajuato Festival Gastronomico was held at La Hacienda San Cristobal ... November 9, 2019. The event featured a total of 18 renowned Chef’s from Latin ...
(Date:11/14/2019)... ... 14, 2019 , ... In a first of its kind ... have performed a pioneering coronary intervention with an Impella heart assist device ... The new procedure offers surgeons another option to help save the lives of ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... ... November 19, 2019 , ... Liquid nutrients have reigned supreme ... space have been transitioning to powdered nutrients because of the cost-effectiveness and ease of ... difficulty in combining essential macro and micronutrients, most nutrient companies package them separately, forcing ...
(Date:11/19/2019)... ... 18, 2019 , ... San Antonio-based businesses, Rodkeys and Massage ... sales through a new partnership announced today. This collaboration has the potential to ... A selection of Rodkeys branded non-THC CBD products are now available at more ...
(Date:11/19/2019)... ... 2019 , ... Respected Hollywood actor and film director, Laurence ... Laurence Fishburne. The program’s central focus is to inform the general public about ... be aired on the show, a new segment covering TMJD (Temporomandibular Disorder) and ...
Breaking Medicine Technology: