St. Jude Finds Link Between Cellular Defense Processes, Showing How Cancer Cel... (velop and fuse with thelysosome even if ...)

St. Jude Finds Link Between Cellular Defense Processes, Showing How Cancer Cells Survive

Date:12/19/2007

velop and fuse with the lysosome even if autophagy itself doesn't occur simultaneously," said Douglas Green, Ph.D., chair of the St. Jude Department of Immunology and senior author of the report.

"Now that we discovered that phagocytosis uses some of the same biochemical signals as autophagy does, we can use that information to solve the mystery of how autophagy works," said Miguel Sanjuan, Ph.D., a staff scientist in Green's laboratory and first author of the report.

Other authors of this paper include Christopher P. Dillon, Stephen W. G. Tait, Simon Moshiach, Samuel Connell and Sebo Withoff (St. Jude); Masaaki Komatsu and Keiji Tanaka (Tokyo Metropolitan Institute of Medical Science, Japan); Frank Dorsey and John L. Cleveland (The Scripps Research Institute, Jupiter, Florida).

This work was supported by the National Institutes of Health and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.

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