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St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
Date:4/14/2008

mia had the same gene deleted. That finding suggested that the deletion of Ikaros is cooperating with BCR-ABL1 to cause ALL.

"That is an important finding that may give insight into how that transformation occurs, or it may give insight into a better way to treat the disease, if one can figure out how the Ikaros deletion is working," Downing said.

Other authors of this paper include Charles Mullighan, Christopher Miller, Ina Radtke, Letha Phillips, James Dalton, Jing Ma, Ching-Hon Pui, Mary Relling, Sheila Shurtleff (St. Jude); Deborah White and Timothy Hughes (The Institute for Medical and Veterinary Science, Adelaide, Australia); and Michelle Le Beau (University of Chicago, Ill.).

This work was supported by ALSAC. Mullighan was supported by grants from the National Health and Medical Research Council, the Royal Australasian College of Physicians and the Haematology Society of Australasia.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


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