Navigation Links
St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
Date:4/14/2008

ranslocation is the expression of BCR-ABL1, an oncogene.

"It appears from our study, and other work published previously, that all you need to get CML is that chromosomal translocation and BCR-ABL1 expression," Downing said.

In their new study, the researchers re-examined the genetic makeup of 304 ALL patients who had been studied earlier. The group included 43 pediatric and adult BCR-ABL1 ALL patients and 23 adults with CML. Using a more sensitive technology, the scientists increased the number of genetic mutations found in their original gene survey.

In the first study, the gene most commonly altered was one called PAX5, followed by a gene designated IKZF1. Its protein, Ikaros, is involved in the development and differentiation of B lymphocyte cells, which are part of the immune system.

"The vast majority of pediatric acute lymphoblastic leukemias are of B-cell lineage," Downing said.

Among the ALL patients, the researchers found an average of 8.79 copy number alterations, a form of genetic change linked to the development and progression of cancer. The most common change was deletion of the gene for Ikaros.

The gene was deleted in 36 (83.7 percent) of the BCR-ABL1 ALL patients, including 76.2 percent of the pediatric and 90.9 percent of the adult cases.

"The loss of the Ikaros gene is a nearly obligatory lesion for the development of BCR-ABL1 ALL," Downing said, "and clearly must be a genetic lesion that is cooperating with BCR-ABL1."

Moreover, a gene known as CDKN2A was deleted in 53.5 percent of the BCR-ABL1 ALL patients, 87.5 percent of whom also had lost the gene for Ikaros. The PAX5 deletion occurred in 51 percent of the BCR-ABL1 ALL patients; and 95 percent of these people were missing the Ikaros gene.

Among the CML patients whose disease converted to ALL, two out of three had the deletion of the Ikaros gene; a lower percentage of those who converted to acute myeloblastic leuke
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
2. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
3. Pollin Pediatric Research Prize awarded for discovery of lifesaving treatment of RDS
4. Mitosis gets harder thanks to new gene discovery
5. ARCA Discovery Changes Name to ARCA biopharma to Reflect Focus on Drug Commercialization
6. GeneGo Rolls out MetaMiner Cystic Fibrosis - the First Disease-Specific Software Platform to Advance Drug Discovery
7. Baby Madness is Sweeping the Nation! Forty Sets of Twins and Triplets Hit the Court in Discovery Healths BABY MADNESS: MULTIPLES
8. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
9. New protein discovery helps researchers understand autoimmune diseases
10. Specialists in drug discovery and development convene
11. Keystone Programs for Collaborative Discovery Launch at Fox Chase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... York, New York (PRWEB) March 06, 2015 ... dancing’s dazzling days on the grand stage, to the silver ... Dancers sparkle throughout with precision toe-tapping numbers and their famous ... Karyn Tomczak deliver the rich history of tap dancing in ... forms to come out of the United States. , ...
(Date:3/6/2015)... 06, 2015 At Natural Products ... today the launch of its powerful, location-aware iOS ... and sustainable products at any retailer that carries ... at Expo West Booth 6054. , Makeena’s ... Kosher, non-GMO, organic, Paleo, and vegan, among many ...
(Date:3/6/2015)... First Choice Emergency Room opened its ... located at 13351 W. Bowles Avenue, Littleton, Colorado and is ... 24-7 to provide the highest quality emergency medical care to ... First Choice Emergency Room Littleton. , First Choice ... Denver Chamber of Commerce and a medical community open house ...
(Date:3/6/2015)... 06, 2015 Truly Nolen, the largest ... announce the grand opening of their first independently-owned and ... down to the Fort Mill – Rock Hill, SC ... 27th, 2015 at their new location. , ... of collective experience in the pest control industry. Locally ...
(Date:3/6/2015)... The Gluten-Free Certification Program (GFCP), ... pleased to announce that Dufflet Pastries, the ground-breaking ... their product line of gluten-free treats certified by ... as satisfying as any of their other desserts! ... contains hydrogenated fats or oils, artificial flavours, colours ...
Breaking Medicine News(10 mins):Health News:The Legacy Dancers, a Dazzling Dance Troupe of Former Rockettes, Kick to New Heights in “On Tap: From Broadway to the Silver Screen” 2Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 2Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 3Health News:First Choice Emergency Room Opens New Facility in Littleton, Colorado 2Health News:First Truly Nolen Franchise Opening in North Carolina 2Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 2Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 3Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 4
... research team led by Queen,s University have developed a ... new drug will benefit sufferers who have the ,Celtic ... Ireland. The study, which was carried out by ... the Belfast Health and Social Care Trust and teams ...
... LOS ANGELES(June 20, 2011)Doctors warned of a potential public health ... and New York who developed serious skin reactions after smoking ... medication drug dealers are using to dilute, or "cut," up ... report, published online in the Journal of the American ...
... Although sex and infidelity are now only a keyboard ... no substitute for physical, face-to-face contact in our sexual ... Kholos Wysocki, from the University of Nebraska at Kearney, ... They investigated the behaviors of infidelity on the internet ...
... as lesbian, gay, or bisexual increases emotional well-being even ... benefits of revealing one,s sexual identity -- less anger, ... supportive settings, shows a study published June 20 in ... findings underscore the importance of creating workplaces and other ...
... SUNDAY, June 19 (HealthDay News) -- Dads don,t have to forego ... research that has linked red and processed meat consumption to ... M.D. Anderson Cancer Center say that small changes in what people ... toward lowering their risk of cancer. , , "The good news ...
... An international research team, co-led by scientists at ... potential susceptibility genes for development of progressive supranuclear ... symptoms similar to those of Parkinson,s disease ... being published online June 19 in Nature Genetics ...
Cached Medicine News:Health News:Scientists develop first ever drug to treat 'Celtic gene' in cystic fibrosis sufferers 2Health News:Adulterated cocaine causing serious skin reactions 2Health News:Let your fingers do the talking: Sexting and infidelity in cyberspace 2Health News:Is coming out always a good thing? 2Health News:Is coming out always a good thing? 3Health News:Dads Can Light Their Grills Without Fear 2Health News:Possible susceptibility genes found in neurodegenerative disorder 2Health News:Possible susceptibility genes found in neurodegenerative disorder 3
(Date:3/6/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rvhg65/european_patient ) has ... Equipment Market by Product, by Type of Care, by ... report to their offering. The European ... a double-digit CAGR of 11.4% to reach $5,150.2 million ... geriatric population, increasing incidences of lifestyle diseases, and high ...
(Date:3/5/2015)... DETROIT , March 5, 2015   ... percent and met all seven optional leading indicators ... Benefit Management. "We are very proud ... said Rene Acker , Chief Operating Officer ... employees, dedication and commitment to transparency, flexibility and ...
(Date:3/5/2015)... March 5, 2015 Vermillion, Inc. (Nasdaq: ... focused on gynecologic disease, announced today it will ... the market open on Wednesday, March 25, 2015, ... at 8:30am Eastern. Conference Call & Webcast: ... Eastern/5:30am Pacific Domestic: , 800-753-9057International: , 913-981-5571Conference ID: ...
Breaking Medicine Technology:European Patient Handling Equipment (Wheelchair, Scooters, Bathroom Safety Supply, Mechanical, Ambulatory) Market 2015-2019 2European Patient Handling Equipment (Wheelchair, Scooters, Bathroom Safety Supply, Mechanical, Ambulatory) Market 2015-2019 3MeridianRx Earns Highest URAC Accreditation Status 2Vermillion to Report Fourth Quarter and Year-End 2014 Financial Results and Host an Investor Conference Call on March 25 2
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
45 left angled suture passer....
Medicine Products: