Navigation Links
St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
Date:4/14/2008

Finding that a combination of genetic mutations can cause an aggressive form of acute lymphoblastic leukemia could lead to new cancer-fighting therapies

MEMPHIS, Tenn., April 14 /PRNewswire-USNewswire/ -- Researchers at St. Jude Children's Research Hospital have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL).

These defects, known as "cooperating oncogenic lesions," include the deletion of a gene, IKZF1, whose protein, Ikaros, normally helps guide the development of a blood stem cell into a lymphocyte. The researchers also found that loss of the same gene accompanied the transformation of chronic myelogenous leukemias (CMLs) to a life-threatening acute stage.

"These findings provide new avenues to pursue to gain a better understanding of these disease processes and, ultimately, to develop better therapies," said James R. Downing, M.D., St. Jude scientific director and chair of the Department of Pathology.

The new study, which he and his colleagues reported in the advance online publication of the journal "Nature," adds further support to a key concept in cancer genetics: Malignancies frequently require mutations in multiple genes in order to develop.

Cells contain oncogenes, which exist harmlessly until something triggers them to turn the cells malignant.

"It really takes a series of genetic lesions to lead to cancer," Downing said. "You may get activation of an oncogene, but you may also need activation of a tumor suppressor gene and an alteration in a cell-death pathway."

St. Jude researchers sought to identify genetic differences between CML and a form of acute leukemia known as BCR-ABL1positive ALL.

Both diseases are characterized by the Philadelphia chromosome, which results from the translocation (joining) of parts of two different chromosomes. The result of this t
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
2. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
3. Pollin Pediatric Research Prize awarded for discovery of lifesaving treatment of RDS
4. Mitosis gets harder thanks to new gene discovery
5. ARCA Discovery Changes Name to ARCA biopharma to Reflect Focus on Drug Commercialization
6. GeneGo Rolls out MetaMiner Cystic Fibrosis - the First Disease-Specific Software Platform to Advance Drug Discovery
7. Baby Madness is Sweeping the Nation! Forty Sets of Twins and Triplets Hit the Court in Discovery Healths BABY MADNESS: MULTIPLES
8. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
9. New protein discovery helps researchers understand autoimmune diseases
10. Specialists in drug discovery and development convene
11. Keystone Programs for Collaborative Discovery Launch at Fox Chase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... 2015 , ... A July 9 article from USA Today has ... to the American Dental Association. According to a study by the American Dental Association, ... in a single year to 2.2 million a year. Dentists and ADA officials all ...
(Date:8/3/2015)... ... August 03, 2015 , ... From 2006-2017 the number ... according to market research compiled for the National Association of Dental Laboratories ( ... Labor, Bureau of Labor Statistics. As the number of dental laboratories decreases, dentists ...
(Date:8/3/2015)... ... ... Dignity Health named Dr. Norris A. Baldwin, Jr. the Facility Medical Director ... August. The new facility is licensed under Dignity Health Arizona General Hospital ... is an excellent leader and will ensure our new freestanding emergency room delivers the ...
(Date:8/3/2015)... ... 2015 , ... Constantin Vasilica, 48 from Romania wanted to have an alternative ... many years of suffering and using medications with strong side effects. This had already ... extra time off or wait longer hours in the waiting rooms. Instead, he went ...
(Date:8/3/2015)... ... August 03, 2015 , ... Foot and Ankle ... new associate podiatrist, creating the largest medical practice in the Mid-Atlantic region – and ... FASMA operates 21 locations with 33 doctors. , Dr. Hetal Kathrotiya-Mago is a Maryland ...
Breaking Medicine News(10 mins):Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 2Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 3Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 2Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 3Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 2Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 3Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 2Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 3Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 2Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 3Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 4
... , , , ... Governor Schwarzenegger line-item vetoed the Department of Public Health,s ... shelters and centers. , , Services provided ... with restraining orders, counseling and other vital support services. ...
... , , , ... weight management industry, announced today their "Less Is More" campaign, which ... lives and the lives of others through simple, every day thoughtful ... major cities across the country on September 26, 2009 with the ...
... , , , TREVOSE, Pa., ... ) the nation,s largest Italian Ice concept with more than ... $451,000 this June for Alex,s Lemonade Stand Foundation for Childhood Cancer ... of June for the past four years, Rita,s has collectively raised ...
... consisted of 10 patients (three male and seven female) ... years (age range, 19-78 years). Of these patients, dynamic ... with intratumoral fatty density, absence of a capsule, and ... small hepatic angiomyolipomas, with or without a fat component ...
... , , DEERFIELD ... found a promising solution that puts power back in the healthcare ... in an upcoming episode of the show,s series on Solutions for ... http://www.newscom.com/cgi-bin/prnh/20080206/AQW030LOGO-b ) , , The days when ...
... , LIVONIA, Mich., July 30 American ... Individual health insurance, announced today that it has introduced its ... Provider Network will save policyholders an average of 5 percent ... remains committed to ensuring that policyholders have the freedom and ...
Cached Medicine News:Health News:Governor Eliminates Funding to Domestic Violence Programs 2Health News:Metabolife(R) Reminds Us That the Little Things We Do Can Bring Positive Change to Our Lives and the Lives of Others 2Health News:Rita's Squeezes Pediatric Cancer with $451,000 Donation 2Health News:Rita's Squeezes Pediatric Cancer with $451,000 Donation 3Health News:Healthcare: Solutions for the American Crisis 'The Economic Report' Show to Feature Rising Medical Solutions, Inc. 2Health News:Healthcare: Solutions for the American Crisis 'The Economic Report' Show to Feature Rising Medical Solutions, Inc. 3Health News:American Community Introduces Its Own PPO Network in Ohio to Save Policyholders Money 2
(Date:8/3/2015)... , Aug. 3, 2015   ConvergeHEALTH ... pharmaceutical company Allergan plc is expanding ... and Intermountain Healthcare to include women,s ... ConvergeHEALTH,s OutcomesMiner analytics platform to generate real-world clinical ... "We look forward to expanding our ...
(Date:8/3/2015)... Va. , Aug. 3, 2015  Dr. ... joining Orthopaedic & Spine Center today, ... to manage their chronic pain through psychological counseling ... is a Fellowship-trained, certified medical psychologist with ... medicine. His vast experience ranges from assessment and ...
(Date:8/3/2015)... Aug. 3, 2015  BioElectronics Corporation (OTC Pink: BIEL), ... announced that Andrew J. Whelan , President will ... program "On Business" at 9am EDT on Wednesday, August ... tune to: http://tunein.com/radio/Money-Matters-Boston-1120-s27548/ ... exceptional acceptance the company,s flagship product, ActiPatch Therapy, is ...
Breaking Medicine Technology:ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 2ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 3ConvergeHEALTH by Deloitte and Intermountain Healthcare Expand Real World Evidence Collaboration with Allergan to Focus on Women's Health 4Orthopaedic & Spine Center Introduces New Pain Psychologist 2UpTick News Wire Radio Show Will Interview BioElectronics' CEO Andrew Whelan 2
... (NYSE: HSP ), a leading global specialty pharmaceutical ... a conference call to discuss its fourth-quarter and full-year 2010 ... at 8 a.m. Central time. The company will ... before the U.S. stock market open and the conference call. ...
... Eli Lilly and Company (NYSE: LLY ) ... chairman, president, and chief executive officer about his meeting ... economic growth, job creation, American innovation and competiveness: ... biopharmaceutical industry and take part in this very important ...
Cached Medicine Technology:Lilly Statement Regarding President Obama's Meeting With U.S. Business Leaders 2
... Microscope with excellent maneuverability. Konan ... weight maintaining high quality. Easy ... by simply changing the adapter. ... has resulted in a sharp ...
To maintain the conjunctival cul-de-sacs after enucleation or evisceration without hindering lid closure....
With side bite Instrument recommended to catch the polypropylene thread in the nose....
Instrument necessary for insertion of Ritleng Bicanaliculus systems and of Self-Threading Monoka systems....
Medicine Products: