Navigation Links
Spread of cancer cells may be slowed by targeting of protein
Date:12/18/2012

HERSHEY, Pa.--The spread of cancer cells may be slowed by targeting the protein km23-1, according to researchers at Penn State College of Medicine.

A motor protein that transports cargo within the cell, km23-1 is also involved in the movement or migration of cells. Migration is necessary for cancer to spread, so understanding this cell movement is important for development of better cancer treatments.

Kathleen Mulder, Ph.D., professor, biochemistry and molecular biology, looked for partner proteins that bind to and cooperate with km23-1 during cell movement, which turned out to include factors that can control proteins actin and RhoA.

"Cell migration is an important aspect of the process of a tumor spreading," Mulder said. "Changes in this process transform tumor cells from local, noninvasive, confined cells to the migrating, metastatic cancer cells."

Cells move through the body using the protein actin, which forms the structural frame of the cell, called the cytoskeleton. The actin creates a protrusion in the cell membrane by forming strands of thread-like fibers on the leading edge of the cell, pushing the cell forward. Several identified proteins regulate the reorganization of the cytoskeleton and are more active in several types of cancers.

Overexpression of km23-1 increases actin fiber formation, whereas when km23-1 is diminished, RhoA activity decreases. RhoA is known to be an important switch, activating processes in migration.

"By knowing that RhoA activity was decreased when km23-1 was reduced, we infer that km23-1 is needed for the regulation of these switches and has a role in cell movement," Mulder said.

To test this in the lab, km23-1 was reduced in a sample of human colon cancer cells. When km23-1 was diminished, cancer cells migrated less. More research needs to be done, but km23-1 may be a promising target for anti-metastatic drugs and cancer therapies to slow the spread of the disease.

"By inhibiting km23-1, you inhibit events that contribute to the cells spreading to other parts of the body," Mulder said.


'/>"/>

Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. NIH scientists link quickly spreading gene to Asian MRSA epidemic
3. Can Heavy Metal in Foods, Cosmetics Spur Breast Cancer Spread?
4. Researchers gain better understanding of mechanism behind tau spreading in the brain
5. Genetic test identifies eye cancer tumors likely to spread
6. Fertilizing bone marrow helps answer why some cancers spread to bones
7. Genes Might Be Key to Parkinsons Spread
8. Benefits of Widespread Statin Use Outweigh Risks: Study
9. Antibiotic-Resistant Gonorrhea Spreading: WHO
10. PawnUp.com Online Pawn Shop Spreads Awareness About its Small Business Loans.
11. Following the genomic pathways to stop the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting at a ... to wait until March 2017 for an interest rate increase, according to Rajeev Dhawan ... Business. , “The Federal Open Market Committee (FOMC) dot charts are of interest to ...
(Date:5/26/2016)... St. Louis, Missouri (PRWEB) , ... May 26, ... ... optimal cost, quality and clinical outcomes, hosted members and suppliers for its inaugural ... with a focus on their mission of elevating the operational health of America’s ...
(Date:5/26/2016)... ... 26, 2016 , ... The Woodlands at John Knox Village , Florida’s ... care for living and healing, celebrated its grand opening, today. The Woodlands at John ... provided by Empowered Staff. , “This is an incredibly fulfilling time for John Knox ...
(Date:5/26/2016)... N.J. (PRWEB) , ... May 26, 2016 , ... ... delivery technologies and development solutions for drugs, biologics, consumer health and global clinical ... sales office in Korea to support the company’s continued investment and strategic growth ...
(Date:5/26/2016)... ... , ... Memorial Day Weekend marks the unofficial start of summer and the ... make sure your family and vehicle are ready to hit the road this weekend. ... deaths and an additional 50,500 serious injuries from motor vehicle crashes during the three-day ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Zymo Research Corp. ... their new reference materials that help researchers obtain ... collection to analyses. The rapid growth of the ... researchers to have standard methods to improve the ... Biases inherently exist at every step of the ...
(Date:5/25/2016)... May 25, 2016  Granger Diagnostics today announced immediate ... wounds and infections. This test ensures discovery of ... viruses. The test requires only a simple swab of ... David G. Bostwick , MD, Chief Medical ... wound healing: "We are excited to make available, ...
(Date:5/25/2016)... , May 25, 2016 ... H1 2016"market research report that provides an overview ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
Breaking Medicine Technology: