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Split-dose preparation for colonoscopy increases precancerous polyp detection rates
Date:9/19/2012

y for screening and surveillance of colon polyps and cancer were included in the study.

The bowel preparation choices for split dosing were four-liter PEG electrolyte solution or MoviPrep (Salix Pharmaceuticals Inc., Raleigh, NC). Patients were instructed to avoid eating a high-fiber diet for two days before taking the bowel preparation and to drink only clear liquids for the entire day before colonoscopy. With the four-liter PEG solutions, patients were instructed to drink three liters the night before, starting at 6:00 pm, and one liter at least four hours before the scheduled procedure time on the day of the procedure. Patients using MoviPrep (after preparing the solution according to manufacturer's specifications) were instructed to drink half of the volume the night before colonoscopy, starting at 6:00 pm, and the other half at least four hours before the scheduled procedure time on the day of the procedure. All patients were instructed to take nothing by mouth for at least three hours before the procedure. Patients who had an early morning procedure or long travel time to the endoscopy unit were offered the option of taking the entire preparation the night before (nonsplit dose).

Results

After the application of exclusion criteria, there were 3,560 patients in the pre-SDP group and 1,615 patients in the post-SDP group. The pre-SDP and post-SDP patient groups were similar in age, body mass index, and gender. The mean ages of patients were 62 and 61 years, respectively, in the pre-SDP and post-SDP groups. SDP use increased significantly from 9 percent to 74 percent after implementation. In comparison with the pre-SDP group, both PDRs (44.1 percent to 49.5 percent) and ADRs (26.7 percent to 31.8 percent) significantly improved in the post-SDP group. The cecal intubation rate significantly increased from 93.6 percent to 95.5 percent in the post-SDP group.

Bowel preparation quality also improved significantly in the post-SDP g
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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