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Split-dose preparation for colonoscopy increases precancerous polyp detection rates
Date:9/19/2012

iance, leading to a poor preparation. Recent studies have explored new approaches in administering PEG solutions to improve patient tolerability, compliance, and efficacy. Splitting the preparation is such an approach. Patients are advised to consume two or three liters the night before and one or two liters the morning of the procedure.

"A recent meta-analysis of randomized studies using split-dose preparations suggested a significant improvement in the quality of preparation and patient compliance. However, the effects of split-dose preparations on other quality indicators of colonoscopy, such as cecal intubation (colonoscopy completion) and adenoma detection rates, have not been evaluated, as far as we know," said study lead author Suryakanth R. Gurudu, MD, Division of Gastroenterology and Hepatology, Mayo Clinic Arizona. "In our study, we have demonstrated, for the first time to our knowledge, that system-wide implementation of a split-dose preparation for colonoscopy significantly improves both polyp detection rates and adenoma detection rates as well as improves the quality of the preparation and colonoscopy completion rates. These results confirm the benefit of split-dose preparations and the importance of bowel preparation in the detection of colon polyps."

Methods

The primary aim of this study was to compare polyp detection rates (PDRs) and adenoma detection rates (ADRs) before and after implementation of split-dose preparations (SDP) as the preferred bowel preparation in a tertiary GI practice. Secondary goals were to compare the quality of the preparation and cecal intubation rates (colonoscopy completion rate) before and after implementation of the SDP. This was a retrospective study at Mayo Clinic Arizona. Electronic medical records of all the patients who underwent colonoscopy from January 2009 to December 2009 (before SDP) and from October 2010 to March 2011 (after SDP) were reviewed. All patients who underwent colonoscop
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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