Navigation Links
Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
Date:2/16/2010

Research published in the February edition of the Journal of Thoracic Oncology sought to assess the overall efficacy of split-course palliative chest radiotherapy (RT) for symptom relief in patients with advanced non-small cell lung cancer. Additionally, researchers investigated the impact the regimen's two-week break has on survival outcomes.

The majority of lung cancer patients present with locally advanced or stage IV disease. The primary challenge in treating these patients is that most present with poor performance status, and the benefit of treatment may be doubtful because of poor tolerance to any form of therapy. Palliative chest RT for lung malignancies has shown to be effective in relieving serious chest symptoms from tumor bleeding or mass effect on major airways, vessels and nerves. However, there is a lack of consensus for an optimal palliative RT regimen.

Researchers reviewed the medical records of 140 patients in a retrospective analysis. The team evaluated symptom relief and toxicity during and after completion of RT treatment from clinician notes and patient-reported symptom inventory forms. Then, the researchers examined the impact of the treatment regimen on survival rates. Symptomatic relief was observed in all types of chest symptoms with an extent ranging from 52-84 percent. Long-lasting symptom relief was experienced in 58 percent of patients. Therapy was well-tolerated, and toxicity was mild and transient, with grade 1 or 2 treatment-related esophagitis completely resolved during the two-week break. Furthermore, cancer survival was not adversely affected by a break in treatment.

"Balancing symptomatic relief with the side effects of radiotherapy remains a critical element of patient treatment," explains lead investigator, Su K. Metcalfe, MD, MPH of the James P. Wilmot Cancer Center at the University of Rochester. "Our selection design represents a viable option for patients who cannot tolerate continuous radiation treatment courses. Furthermore, the study's finding provides the basis for future large prospective studies that evaluate split-course palliative chest radiotherapy against other regimens.


'/>"/>

Contact: Megan Richter
mrichter@spectrumscience.com
202-587-2556
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Center to Advance Palliative Care Director and MacArthur Recipient, Diane E. Meier, MD, Accepts Fellowship Post With Senate HELP Committee
2. San Diego Hospice and The Institute for Palliative Medicine on the Passing of Sol Price
3. Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care
4. Journal of Hospice & Palliative Nursing Names New Editor
5. The Regence Foundation Announces Debut of Sojourns Award for Innovation and Leadership in Palliative Care
6. Regence Foundation Launches Palliative Care Grantmaking Program in Idaho, Oregon, Utah and Washington
7. New Palliative Medicine Hotline Reaches California
8. San Diego Hospice and The Institute for Palliative Medicine Program Wins National American Psychiatric Association Gold Achievement Award
9. Discovering the Voice of Hospice and Palliative Care Worldwide: World Hospice and Palliative Care Day - October 10, 2009
10. New Palliative Medicine Fellowship Created to Train Pacific Northwest Doctors in End-of-Life Care
11. SIUE School of Pharmacy Launches Collaborative Site for Pain, Palliative Care Pharmacy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 26, 2016 , ... There are many ways to cook a hot dog, ... that Americans prefer their dogs straight off the grill. Of the 90 percent of ... way to cook a hot dog, far outpacing other cooking methods such as steaming ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, ... defective respirators, according to court documents and SEC filings. A jury has ... Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State ... its specialty academic programs. , Answering to the increasing demand for curricular specializations, ... health law, and environmental and land use law. ,  , “The demand for ...
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For Heroes ... lives in military battle for the country. The nonprofit Hope For Heroes partnered ... programs that empower independence for disabled military veterans, as well as police, firemen, and ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac ... significant negative impact on long-term patient survival, reports a team of UPMC researchers ... this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland , ... QGEN ; Frankfurt Prime Standard: QIA) today announced ... agreement with Therawis Diagnostics GmbH to develop and commercialize predictive ... and market PITX2 as a marker to predict effectiveness of ... patients. "We are pleased to partner with Therawis, ...
(Date:5/25/2016)... , May 25, 2016 As ... Expo earlier this month, the numbers and momentum of ... to climb into the billions, more research and development ... 4th Edition State of Legal Marijuana Markets Report  from ... data-analysis firm, much of the increase in sector is ...
(Date:5/25/2016)... Inivata, a global clinical ... tumour DNA (ctDNA) analysis to improve personalised healthcare ... Clive Morris as Chief Medical Officer. ... development programme, scientific collaborations, and through to commercialisation ... in clinical outcomes for patients. Clive ...
Breaking Medicine Technology: