Navigation Links
Spinal fluid proteins signal Lou Gehrig's disease
Date:1/28/2009

High levels of certain proteins in the spinal fluid could signal the onset of Lou Gehrig's disease, according to researchers. The discovery of these biomarkers may lead to diagnostic kits for early diagnosis, accurately measuring the progression of the disease and monitoring the effects of treatment.

Lou Gehrig's disease -- or Amyotrophic Lateral Sclerosis (ALS) -- is caused by the degeneration of nerve cells controlling the voluntary movement of muscles. However, it is hard to diagnose because symptoms such as muscle weakness are common in other ailments and currently, there is no diagnostic test for the disease.

"The disease has to progress far enough so that the patient begins to experience significant muscle weakness, so that a physician can identify the problem," said James Connor, distinguished professor and vice-chair of neurosurgery, Penn State Hershey. "If we had a biomarker we could start treatments earlier and perhaps save more nerve cells and slow the disease."

The problem is compounded by the speed at which the disease progresses. In some patients the disease can run its course in just a couple of years, while in others it can take seven to ten years.

To find an early warning signal for the onset of Lou Gehrig's disease, Connor and his colleagues, Zachary Simmons and Ryan Mitchell at the Hershey Medical Center, focused their attention on proteins related to inflammation in the spinal cord. Studies show that the progression of the disease involves excessive inflammation of nerve cells. The team also argued that because these proteins tend to be much smaller than most other proteins, they are likely to be overlooked in large-scale protein studies.

The researchers extracted spinal fluid from two groups of patients. The first group, comprising 41 patients, was known to have Lou Gehrig's disease, while the second group of 31 patients complained of muscle problems such as weakness and cramps.

Next, the researchers tested th
'/>"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cialis Eases Erectile Dysfunction After Spinal Cord Injury
2. Summit on Spinal Muscular Atrophy
3. New Low-Back Pain Guidelines Should Encourage Patients to Utilize Spinal Manipulation
4. Pioneer Surgical Technology Hires New Spinal Franchise Manager
5. Video: Kyphon Supports World Osteoporosis Day on October 20, 2007 to Raise Awareness of Osteoporosis and Spinal Fracture Risk
6. Mayo Clinic clarifies diagnosis for serious blood vessel disease of brain and spinal cord
7. Spinal cord injury expert to be honored by research foundation
8. ArthroCare Releases New SpineWand(R) for Less Invasive Spinal Surgeries
9. Engineers developing new cements to heal spinal fractures
10. Polyanalgesic Consensus Panels New Treatment Guidelines Via Intraspinal Infusion for Severe Chronic Pain
11. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
(Date:12/25/2014)... 2014 AngelWeddingDress.com tries its best to ... realm. Today, the business has introduced its new collection ... dress promotion. , The new prom outfits are guaranteed ... dress lover. They are specially designed for 2015. Anyone ... dresses should visit its website before Jan. 26, 2015, ...
(Date:12/25/2014)... 2014 Plugin creators from Pixel Film ... fully customizable business presentation tool made specifically for ... 5k business tool, users can now display their stats ... Pixel Film Studios. “ProFire 5k gives users a multiple ... professionalism to a presentation” , Pixel Film Studios takes ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2
... monoclonal antibodies effective against bird and seasonal flu ... working with researchers at the Dana-Farber Cancer Institute ... reported the identification of human monoclonal antibodies that ... including avian influenza A (H5N1) virus, previous pandemic ...
... the Jobseekers Facelift Giveaway ContestSAN FRANCISCO, May 12 ... Kim has established a Jobseekers Facelift Giveaway Contest. ... jobs, older applicants (those over 40) see facial surgery ... with younger applicants. "Of course, one,s accomplishments should set ...
... a leading innovator of noninvasive physiological monitoring solutions, ... oximeter, announced today the release of its personal ... The all-new GO2 provides patients a proven, cost-effective, ... oxygen saturation to complement their clinician-advised oxygen therapy ...
... those needing to work from home or on ... Ericom Software, a global leader in Application Access ... access solution, PowerTerm WebConnect can significantly reduce the ... during disaster situations, such as an H1N1 pandemic ...
... research grants to help solve some of the biggest ... the Engineering and Physical Sciences Research Council (EPSRC) , ... and treating major public health issues such as cancer, ... grants, worth 16.5m, have been given by the EPSRC, ...
... Bleak, NCPA Says It,s Much Worse DALLAS, May 12 ... today - will likely paint an extremely bleak future ... of trillions of dollars. As bad as those projections ... according to NCPA experts. "The reality is that Medicare ...
Cached Medicine News:Health News:Recent developments at Burnham Institute for Medical Research, May 2009 2Health News:Recent developments at Burnham Institute for Medical Research, May 2009 3Health News:Recent developments at Burnham Institute for Medical Research, May 2009 4Health News:Recent developments at Burnham Institute for Medical Research, May 2009 5Health News:Want to Help Your Job Hunt? Win a Facelift! 2Health News:Nonin Medical's GO2(TM) Personal Fingertip Pulse Oximeter Empowers Patients Worldwide 2Health News:Ericom's Remote Access and Business Continuity Solution Increases Immunity to Productivity Losses -- Combats Swine Flu Scare 2Health News:Ericom's Remote Access and Business Continuity Solution Increases Immunity to Productivity Losses -- Combats Swine Flu Scare 3Health News:$24.4 million for research into future health care solutions 2
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)...   TRU-D SmartUVC LLC, producers of the ... today that the General Services Administration has awarded the ... This newly formed agreement will allow TRU-D ... purchasers, including Department of Veteran Affairs and Department of ... purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... , Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... the treatment and management of epilepsy, today announced it will ... Conference on Wednesday, January 14, 2015, in San ... President and Chief Executive Officer, will speak at 11:00 AM ... be accessed by clicking on the Investor Relations link on ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... April 27 SI-BONE, Inc. ( Cupertino, California ), ... minimally invasive surgical (MIS) device to treat the sacroiliac (SI) joint ... at upcoming 2010 minimally invasive spine surgery meetings. , ... SI-BONE has been working with ...
... CareFusion Corporation (NYSE: CFN ) today announced plans to release third ... close of trading on the New York Stock Exchange. , ... The company will host a webcast and conference call on May 6 ... to discuss the results for its third quarter, ended on March 31, 2010 ...
Cached Medicine Technology:iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 2iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 3iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 4CareFusion Will Host an Earnings Conference Call on May 6 to Discuss the Results for the Third Quarter of Fiscal 2010 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: