Navigation Links
Spinal cord injury research hampered by animal models, says new study
Date:4/28/2008

WashingtonResearch on traumatic spinal cord injuries is hampered by a reliance on animal experiments that dont accurately predict human outcomes, says a new study in the upcoming edition of the peer-reviewed journal Reviews in the Neurosciences. The review was written by scientists with the Physicians Committee for Responsible Medicine.

Despite decades of animal experiments, we still dont have a drug to cure spinal cord injury in humans, says Aysha Akhtar, a neurologist with PCRM and the lead author. According to the Journal of the American Paraplegic Society, at least 22 agents were found to improve spinal cord injury in animals, but not one of these was helpful in humans, says Dr. Akhtar.

The paper outlines the numerous problems with translating animal data into effective human treatments, including the many variations between laboratory-induced injuries in animals and human injuries, the difficulties in interpreting functional outcomes in animals, and the multitude of inter-species differences in physiology and anatomy.

The extrapolation problem, in general, has been widely acknowledged by scientists of many disciplines and affiliations. According to data from the Food and Drug Administration, more than 90 percent of drugs that proved successful in animal tests are not approved for wider use after clinical trials in humans. In February, three U.S. government agencies, including the National Institutes of Health, the Environmental Protection Agency, and the National Toxicology Program announced a major new program aimed at ending the use of animals in safety testing of new chemicals and drugs.

Because of the extrapolation challenge, some fields, such as cancer research and toxicity testing, are moving toward a greater use of alternatives. Unfortunately, spinal cord research, a relatively newer endeavor, is not yet learning from the failure of other fields of inquiry. As Dr. Akhtar warns, We need to develop new, more ef
'/>"/>

Contact: Simon Chaitowitz
schaitowitz@pcrm.org
202-686-2210
Physicians Committee for Responsible Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Future of Spine Care Has Just Gotten Better With the Use of SpineSix BioMotion Spinal System(TM)
2. Dynatronics Introduces New DynaPro Spinal Health System and X5 Turbo
3. U of M researchers identify process that may help treat Parkinsons, spinal cord injuries
4. Gel Enables Severed Spinal Cord Fibers to Regrow
5. Alberta physiologist earns top national honor for spinal cord research
6. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
7. Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases Disability
8. Physical Therapists Offer Low-Cost Solution to High-Cost Expenditures for Spinal Conditions
9. UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
10. UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
11. UCLA scientists restore walking after spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... plans its exit strategy from the war, now may be ... health care to veterans, says a Perspective piece in the ... go on doing more of the same is to fail ... and population structure pose in the longer run," said William ... Practice, and David Auerbach, from the RAND Corporation, in the ...
(Date:8/28/2014)... The Governor of Yucatán, Rolando Zapata Bello, ... press conference; this event is organized by the Microcredit ... through the National Microenterprise Financing Program ( PRONAFIM ) ... 5th at the Convention Center Yucatan Siglo XXI in ... responsibility for Yucatan to host the 17th Microcredit Summit ...
(Date:8/28/2014)... Bank lending to the private sector in the ... in real terms, and continuing to fall behind the rest ... the international accountancy network. , UHY warns that the figures ... credit crunch lingers on. , UHY says in the US, ... been wiped out by inflation. Over the four years since ...
(Date:8/28/2014)... did the earliest birds take wing? Did they fall from ... Or did they run along the ground and pump their ... million years in the past, but a new University of ... birds have an innate ability to maneuver in midair, a ... rather than fall from a perch. , The study looked ...
(Date:8/28/2014)... August 28, 2014 (BRONX, NY) Researchers from ... other institutions have developed a potential antibody therapy for Sudan ... Ebola. A different strain, the Zaire ebolavirus (EBOV), is now ... numerous Ebola outbreaks (most recently in 2012) that ... were reported in ACS Chemical Biology . , ...
Breaking Medicine News(10 mins):Health News:A VA exit strategy 2Health News:Governor of the State of Yucatan presents the 17th Microcredit Summit 2Health News:Governor of the State of Yucatan presents the 17th Microcredit Summit 3Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 2Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 3Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 4Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 5Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 6Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 7Health News:Flapping baby birds give clues to origin of flight 2Health News:Flapping baby birds give clues to origin of flight 3Health News:Drug shows promise against Sudan strain of Ebola in mice 2
... carcinoma in situDCISwho later develop invasive breast cancer in ... from breast cancer than those who do not develop ... 11 in the Journal of the National Cancer ... have compared breast conserving surgery (lumpectomy) to mastectomy and ...
... , FRIDAY, March 11 (HealthDay News) -- Taking ... but mostly in people at increased risk for the ... in their blood, according to a new study. ... or other nonsteroidal anti-inflammatory drugs (NSAIDs) have a reduced ...
... March 11 (HealthDay News) -- Watching your team win a ... be thrilling, but there may be a drawback: aggressive, testosterone-fueled ... found that traffic deaths at the game site and the ... game is over. Researchers at North Carolina State University ...
... are a burning issue. A straightforward guide to a closer understanding ... 2011). The Dose Makes the Poison: A Plain-Language Guide to Toxicology, ... leads to a distortion in many people,s conceptions of toxins and ... We are exposed to media reports on a daily basis of ...
... DETROIT Theories have long proposed that testosterone influences ... a recent study at Wayne State University give a ... mating behavior, and how testosterone is associated with dominance ... of an attractive woman. The study engaged ...
... causes AIDS invades human immune cells and causes ... can then infect new cells. A research team led ... Priv.-Doz. Dr. Barbara Mller of Heidelberg University Hospital have ... infected cell in virion release, and discovered that the ...
Cached Medicine News:Health News:DCIS patients who get invasive breast cancer have higher mortality 2Health News:Aspirin May Protect Against Colorectal Cancer -- But Only in Certain People 2Health News:Fans of Winning Teams Linked to Fatal Crashes 2Health News:'The Dose Makes the Poison: A Plain-Language Guide to Toxicology,' 3rd Edition 2Health News:Wayne State study links testosterone with men's ability to 'woo' potential mates 2Health News:Pushing HIV out the door: How host factors aid in the release of HIV particles 2
(Date:8/28/2014)... Aug. 28, 2014 Telik, Inc. (OTCQB: TELK), ... merged with MabVax Therapeutics, Inc. on July 8, ... related to the development of its lead antibody ... using the Company,s internally developed antibody discovery platform. ... multiple antibody based therapeutic and diagnostic products based ...
(Date:8/28/2014)... N.H. , Aug. 28, 2014  Critical ... Hampshire , today announces the expansion of ... Critical Process Filtration now offers customers and ... in fluids to filter failure analyses (even for ... addition to their hallmark services of system benchmarking ...
(Date:8/28/2014)... , Aug. 28, 2014  A decline in ... generics are adding pressure to pharmaceutical, biotechnology and ... resources continue to shrink and approval processes and ... led companies to look for additional support and ... for keeping approved products on the market.  ...
Breaking Medicine Technology:Telik Reports Progress Toward Multiple Early Stage Milestones in the Development of a Novel Antibody-based Therapeutic Agent for Gastrointestinal Cancers 2Telik Reports Progress Toward Multiple Early Stage Milestones in the Development of a Novel Antibody-based Therapeutic Agent for Gastrointestinal Cancers 3Telik Reports Progress Toward Multiple Early Stage Milestones in the Development of a Novel Antibody-based Therapeutic Agent for Gastrointestinal Cancers 4Critical Process Filtration, Inc. Announces Expanded Technical Services and Validation Support 24 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 24 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 34 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 4
... , SARASOTA, Fla. , Jan. 15 ... its Senior Subordinated Convertible Notes due 2034 (CUSIP No. 776696AA4) (the "Notes") ... to July 15, 2010 at an annual rate of ... trading days ended July 13, 2010 . Contingent cash interest, which ...
... , SCOTTSDALE, Ariz. , Jan. 15 ... pharmaceutical competitive intelligence and market research, has published a ... therapies to treat hematologic malignancies.  These reports are based ... America immediately following the American Society of Hematology ...
Cached Medicine Technology:New MedPredict Report Highlights Recent Advances in Management of Malignant Hematology 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: