Navigation Links
Spinal cord injury research hampered by animal models, says new study
Date:4/28/2008

WashingtonResearch on traumatic spinal cord injuries is hampered by a reliance on animal experiments that dont accurately predict human outcomes, says a new study in the upcoming edition of the peer-reviewed journal Reviews in the Neurosciences. The review was written by scientists with the Physicians Committee for Responsible Medicine.

Despite decades of animal experiments, we still dont have a drug to cure spinal cord injury in humans, says Aysha Akhtar, a neurologist with PCRM and the lead author. According to the Journal of the American Paraplegic Society, at least 22 agents were found to improve spinal cord injury in animals, but not one of these was helpful in humans, says Dr. Akhtar.

The paper outlines the numerous problems with translating animal data into effective human treatments, including the many variations between laboratory-induced injuries in animals and human injuries, the difficulties in interpreting functional outcomes in animals, and the multitude of inter-species differences in physiology and anatomy.

The extrapolation problem, in general, has been widely acknowledged by scientists of many disciplines and affiliations. According to data from the Food and Drug Administration, more than 90 percent of drugs that proved successful in animal tests are not approved for wider use after clinical trials in humans. In February, three U.S. government agencies, including the National Institutes of Health, the Environmental Protection Agency, and the National Toxicology Program announced a major new program aimed at ending the use of animals in safety testing of new chemicals and drugs.

Because of the extrapolation challenge, some fields, such as cancer research and toxicity testing, are moving toward a greater use of alternatives. Unfortunately, spinal cord research, a relatively newer endeavor, is not yet learning from the failure of other fields of inquiry. As Dr. Akhtar warns, We need to develop new, more effective research techniques.

Although scientists have just begun to develop alternatives to the use of animals in spinal cord injury research, several techniques show great promise. Researchers at the University of Miami, for example, are collaborating on the Human Spinal Cord Injury Model Project which uses imaging techniques, post-mortem analysis, and nerve conduction methods to understand human spinal cords. Other promising directions involve computer modeling, studies on human nerve tissues, and the study of human cadavers.

At least 250,000 Americans are living with spinal cord injuries; an estimated 10,000 Americans are diagnosed each year.


'/>"/>

Contact: Simon Chaitowitz
schaitowitz@pcrm.org
202-686-2210
Physicians Committee for Responsible Medicine
Source:Eurekalert

Related medicine news :

1. The Future of Spine Care Has Just Gotten Better With the Use of SpineSix BioMotion Spinal System(TM)
2. Dynatronics Introduces New DynaPro Spinal Health System and X5 Turbo
3. U of M researchers identify process that may help treat Parkinsons, spinal cord injuries
4. Gel Enables Severed Spinal Cord Fibers to Regrow
5. Alberta physiologist earns top national honor for spinal cord research
6. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
7. Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases Disability
8. Physical Therapists Offer Low-Cost Solution to High-Cost Expenditures for Spinal Conditions
9. UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
10. UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
11. UCLA scientists restore walking after spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... The National ... is pleased to announce the organization’s Certified Strength Coach credential has earned accreditation ... Coach (CSC) program validates the competency of qualified candidates for jobs in the ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech For ... the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at its ... LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment to ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients looking for ... Orthodontics, with or without a referral, from the multi-specialty Dr. Smile practice. Dr. ... is skilled in providing patients with the custom, convenient and long-lasting orthodontic treatment ...
(Date:5/22/2017)... ... 2017 , ... Dr. Kiya Green, a periodontist in Matthews, ... treatments, including crown lengthening and gum reduction surgery, with or without ... procedures to help patients improve their oral health, reduce gummy smiles and achieve ...
(Date:5/22/2017)... ... May 22, 2017 , ... Faithfully following pop culture, ... squatted, stretched, jumped, toned and shaped through fitness programs. It carries on to skin ... finished off with an irresistible, radiant smile. CDA has found that just ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Hologic, Inc. (Nasdaq: ... for the fiscal second quarter ended April 1, 2017 ... $1.84 increased 666.7% compared to the prior year period ... in a significant gain, while non-GAAP diluted EPS of ... or 3.8% in constant currency terms.  Excluding the effects ...
(Date:5/10/2017)... , May 10, 2017 Radiology has ... unfortunately its costs have also spiraled to the number ... sent to radiology than ever before as the most ... For a patient with lower back pain an MRI ... anatomical reason for pain, resulting in entirely different treatment ...
(Date:5/9/2017)...  Demonstrating its commitment to representing research- based ... Pharmaceutical Research and Manufacturers of America (PhRMA) today ... now have to meet new research and development ... join PhRMA. "By putting in place ... clear message that being a member of PhRMA ...
Breaking Medicine Technology: