Navigation Links
Spinal cord injury research hampered by animal models, says new study
Date:4/28/2008

WashingtonResearch on traumatic spinal cord injuries is hampered by a reliance on animal experiments that dont accurately predict human outcomes, says a new study in the upcoming edition of the peer-reviewed journal Reviews in the Neurosciences. The review was written by scientists with the Physicians Committee for Responsible Medicine.

Despite decades of animal experiments, we still dont have a drug to cure spinal cord injury in humans, says Aysha Akhtar, a neurologist with PCRM and the lead author. According to the Journal of the American Paraplegic Society, at least 22 agents were found to improve spinal cord injury in animals, but not one of these was helpful in humans, says Dr. Akhtar.

The paper outlines the numerous problems with translating animal data into effective human treatments, including the many variations between laboratory-induced injuries in animals and human injuries, the difficulties in interpreting functional outcomes in animals, and the multitude of inter-species differences in physiology and anatomy.

The extrapolation problem, in general, has been widely acknowledged by scientists of many disciplines and affiliations. According to data from the Food and Drug Administration, more than 90 percent of drugs that proved successful in animal tests are not approved for wider use after clinical trials in humans. In February, three U.S. government agencies, including the National Institutes of Health, the Environmental Protection Agency, and the National Toxicology Program announced a major new program aimed at ending the use of animals in safety testing of new chemicals and drugs.

Because of the extrapolation challenge, some fields, such as cancer research and toxicity testing, are moving toward a greater use of alternatives. Unfortunately, spinal cord research, a relatively newer endeavor, is not yet learning from the failure of other fields of inquiry. As Dr. Akhtar warns, We need to develop new, more effective research techniques.

Although scientists have just begun to develop alternatives to the use of animals in spinal cord injury research, several techniques show great promise. Researchers at the University of Miami, for example, are collaborating on the Human Spinal Cord Injury Model Project which uses imaging techniques, post-mortem analysis, and nerve conduction methods to understand human spinal cords. Other promising directions involve computer modeling, studies on human nerve tissues, and the study of human cadavers.

At least 250,000 Americans are living with spinal cord injuries; an estimated 10,000 Americans are diagnosed each year.


'/>"/>

Contact: Simon Chaitowitz
schaitowitz@pcrm.org
202-686-2210
Physicians Committee for Responsible Medicine
Source:Eurekalert

Related medicine news :

1. The Future of Spine Care Has Just Gotten Better With the Use of SpineSix BioMotion Spinal System(TM)
2. Dynatronics Introduces New DynaPro Spinal Health System and X5 Turbo
3. U of M researchers identify process that may help treat Parkinsons, spinal cord injuries
4. Gel Enables Severed Spinal Cord Fibers to Regrow
5. Alberta physiologist earns top national honor for spinal cord research
6. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
7. Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases Disability
8. Physical Therapists Offer Low-Cost Solution to High-Cost Expenditures for Spinal Conditions
9. UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
10. UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
11. UCLA scientists restore walking after spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: