Navigation Links
Spinal Fluid Substance May Help Drive Sleep Disorder: Study
Date:11/21/2012

WEDNESDAY, Nov. 21 (HealthDay News) -- A substance found in spinal fluid could act like a natural sleeping pill and help cause hypersomnia, a condition where people sleep more than 70 hours a week, a small new study suggests.

Despite their excessive sleeping, people with the condition also have difficulty waking up in the morning, the researchers noted, and even when awake their reaction times are comparable to someone who has been sleepless all night. Hypersomnia can greatly interfere with patients' daily lives, and conventional treatments such as stimulants do little to help them.

"These individuals report feeling as if they're walking around in a fog -- physically, but not mentally awake," study lead author Dr. David Rye, professor of neurology at Emory University School of Medicine, in Atlanta, and director of research for Emory Healthcare's Program in Sleep, said in a university news release.

Rye and his colleagues looked at seven hyper-sleepy patients and found that their cerebrospinal fluid contained a substance that enhances the effects of a brain chemical called gamma-amino butyric acid (GABA), which is one of the main inhibitory chemicals of the nervous system.

On average, the substance more than doubles GABA receptor function in the patients.

"In some of the more severely affected patients, we estimated the magnitude of the GABA-enhancing effect as nearly equivalent to that expected for someone receiving sedation for outpatient colonoscopy," Rye said. "This is a level of impaired consciousness that many subjects had to combat on almost a daily basis in order to live their usual lives."

"When encountering excessive sleepiness in a patient, we typically think it's caused by an impairment in the brain's wake systems and treat it with stimulant medications," Rye said. "However, in these patients, the situation is more akin to attempting to drive a car with the parking brake engaged. Our thinking needs to shift from pushing the accelerator harder to releasing the brake."

The study was published online Nov. 21 in the journal Science Translational Medicine.

Merrill Mitler, a program director at the U.S. National Institute of Neurological Disorders and Stroke, commended the study.

"Primary hypersomnias are disabling and poorly understood. This study represents a breakthrough in determining a cause for these disorders and devising a rational approach to therapy," Mitler said in the news release. "Further research is required to determine whether or not the results apply to the majority of patients."

Although the study found an association between this particular spinal-fluid substance and hypersomnia, it did not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about hypersomnia.

-- Robert Preidt

SOURCE: Emory University, news release, Nov. 21, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
2. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
3. Severely Obese Have More Complications With Spinal Surgery
4. Re-Routing Spinal Cord Signals Restores Movement in Paralyzed Rats
5. Magnets may help prevent rare complication of spinal anesthesia
6. Surgeon experience affects complication rate of spinal stenosis surgery
7. Researchers determine pathway for origin of most common form of brain and spinal cord tumor
8. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
9. Spinal cord, heal thyself
10. Zebrafish reveal promising mechanism for healing spinal cord injury
11. Musical glove improves sensation, mobility for people with spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Spinal Fluid Substance May Help Drive Sleep Disorder: Study
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
Breaking Medicine Technology: