Navigation Links
Spinal Fluid Substance May Help Drive Sleep Disorder: Study
Date:11/21/2012

WEDNESDAY, Nov. 21 (HealthDay News) -- A substance found in spinal fluid could act like a natural sleeping pill and help cause hypersomnia, a condition where people sleep more than 70 hours a week, a small new study suggests.

Despite their excessive sleeping, people with the condition also have difficulty waking up in the morning, the researchers noted, and even when awake their reaction times are comparable to someone who has been sleepless all night. Hypersomnia can greatly interfere with patients' daily lives, and conventional treatments such as stimulants do little to help them.

"These individuals report feeling as if they're walking around in a fog -- physically, but not mentally awake," study lead author Dr. David Rye, professor of neurology at Emory University School of Medicine, in Atlanta, and director of research for Emory Healthcare's Program in Sleep, said in a university news release.

Rye and his colleagues looked at seven hyper-sleepy patients and found that their cerebrospinal fluid contained a substance that enhances the effects of a brain chemical called gamma-amino butyric acid (GABA), which is one of the main inhibitory chemicals of the nervous system.

On average, the substance more than doubles GABA receptor function in the patients.

"In some of the more severely affected patients, we estimated the magnitude of the GABA-enhancing effect as nearly equivalent to that expected for someone receiving sedation for outpatient colonoscopy," Rye said. "This is a level of impaired consciousness that many subjects had to combat on almost a daily basis in order to live their usual lives."

"When encountering excessive sleepiness in a patient, we typically think it's caused by an impairment in the brain's wake systems and treat it with stimulant medications," Rye said. "However, in these patients, the situation is more akin to attempting to drive a car with the parking brake engaged. Our thinking needs to shift from pushing the accelerator harder to releasing the brake."

The study was published online Nov. 21 in the journal Science Translational Medicine.

Merrill Mitler, a program director at the U.S. National Institute of Neurological Disorders and Stroke, commended the study.

"Primary hypersomnias are disabling and poorly understood. This study represents a breakthrough in determining a cause for these disorders and devising a rational approach to therapy," Mitler said in the news release. "Further research is required to determine whether or not the results apply to the majority of patients."

Although the study found an association between this particular spinal-fluid substance and hypersomnia, it did not prove a cause-and-effect relationship.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about hypersomnia.

-- Robert Preidt

SOURCE: Emory University, news release, Nov. 21, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
2. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
3. Severely Obese Have More Complications With Spinal Surgery
4. Re-Routing Spinal Cord Signals Restores Movement in Paralyzed Rats
5. Magnets may help prevent rare complication of spinal anesthesia
6. Surgeon experience affects complication rate of spinal stenosis surgery
7. Researchers determine pathway for origin of most common form of brain and spinal cord tumor
8. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
9. Spinal cord, heal thyself
10. Zebrafish reveal promising mechanism for healing spinal cord injury
11. Musical glove improves sensation, mobility for people with spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Spinal Fluid Substance May Help Drive Sleep Disorder: Study
(Date:2/27/2017)... ... February 27, 2017 , ... This ... laser diffraction analysis as a tool to characterize particle size distributions in the ... obtain improved results and novel scientific findings. It describes methods of optimized and ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair Institute, a ... new informational post on robotic hair transplantation. San Francisco residents may be confused ... Follicular Unit Transplantation (FUT) can sound similar. Either treatment can be used to ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... lab became the world’s first to be ISO/IEC 17025:2005 INAB accredited for Der ... , ISO/IEC 17025:2005 is the globally recognised standard that sets out requirements for ...
(Date:2/26/2017)... ARLINGTON, VA (PRWEB) , ... February 26, 2017 , ... ... Medicaid Managed Care Summit, February 27-28 at the Sheraton Pentagon City Hotel in Arlington, ... work with PerformCARE to use behavioral health analytics to improve Medicaid population health management. ...
(Date:2/24/2017)... ... February 24, 2017 , ... Houston dentist ... his office, Antoine Dental Center. Currently, patients can get single dental implants for ... but patients can learn more about these offers by contacting Antoine Dental Center. ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... Israel and TAMPA, Fla. , Feb. ... emerging medical device company focused on developing cerebral ... applauds the members of the FDA,s Circulatory System ... their acknowledgement of the need for cerebral protection ... "The statements shared by this FDA panel ...
(Date:2/27/2017)... Feb. 27, 2017  Impax Laboratories, Inc. (NASDAQ: IPXL ) today ... Raymond James and Associates, 38 th ... 2017 in Orlando, FL. Cowen ... ET on March 7, 2017 in Boston, MA. ... 16, 2017 in Miami, FL. ...
(Date:2/27/2017)... 27, 2017  CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and ... , M.D., Ph.D., as President and Chief Executive Officer (CEO) ... 2017. Dr. Craig succeeds Richard Love , interim President ... Board of Directors.  Dr. Craig has over 20 years of ... US and Europe . "On ...
Breaking Medicine Technology: