Navigation Links
Sperm-Producing Cells Coaxed to Produce Insulin

By Serena Gordon
HealthDay Reporter

SUNDAY, Dec. 12 (HealthDay News) -- Researchers have been able to prod human cells that normally produce sperm to make insulin instead and, after transplanting them, the cells briefly cured mice with type 1 diabetes.

"The goal is to coax these cells into making enough insulin to cure diabetes. These cells don't secrete enough insulin to cure diabetes in humans yet," cautioned study senior researcher G. Ian Gallicano, an associate professor in the department of Biochemistry and Molecular and Cellular Biology, and director of the Transgenic Core Facility at Georgetown University Medical Center, in Washington D.C.

Gallicano and his colleagues will be presenting the findings Sunday at the American Society of Cell Biology annual meeting in Philadelphia.

Type 1 diabetes is believed to be an autoimmune disease in which the body mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, people with type 1 diabetes must rely on insulin injections to be able to process the foods they eat. Without this additional insulin, people with type 1 diabetes could not survive.

Doctors have had some success with pancreas transplants, and with transplants of just the pancreatic beta cells (also known as islet cells). There are several problems with these types of transplants, however. One is that as with any transplant, when the transplanted material comes from a donor, the body sees the new tissue as foreign and attempts to destroy it. So, transplants require immune-suppressing medications. The other concern is that the autoimmune attack that destroyed the original beta cells can destroy the newly transplanted cells.

A benefit of the technique developed by Gallicano and his team is that the cells are coming from the same person they'll be transplanted in, so the body won't see the cells as foreign.

The researchers used spermatogonial cells, extracted from the testicles of deceased human organ donors. In the testes, the function of these cells is to produce sperm, according to Gallicano. However, outside of the testes the cells behave a lot like human eggs do, and there are certain genes that turn them on and make them behave like embryonic-like stem cells, he said.

"Once you take them out of their niche, the genes are primed and ready to go," he explained.

After removing the spermatogonial cells from the testes, the researchers put them into a special media. According to Gallicano, it's here that the cells are "chemically" instructed to develop into beta-like cells. In other research attempting to create insulin-producing cells, such as induced pluripotent stem cells, researchers must insert outside genes to get the cells to behave like stem cells. Such outside genes have the potential to lead to additional problems, such as creating cancer.

Once the cells were coaxed into becoming insulin-producing cells, the researchers transplanted them into the mice. The result: blood sugar levels in the mice were reduced for about a week, essentially curing the rodents' diabetes for a brief time, Gallicano said.

He said he hopes that by transplanting the cells into different areas of the body the researchers may be able to achieve longer blood sugar control.

The only side effect of concern, said Gallicano, is a certain type of tumor called a teratoma. But, he said, it appears with these cells it would take significantly more transplanted cells than would likely be needed before such a tumor might potentially be created.

Funding for the study came from the American Diabetes Association, Georgetown University Medical Center and private donors.

"This study is a positive step, but you still have a risk of teratomas, and the autoimmunity could destroy the new insulin-producing cells," said one expert, Dr. Camillo Riccordi, scientific director of the Diabetes Research Institute in Hollywood, Fla. "And the other limitation is that this is only for men, not for women."

But, perhaps a bigger concern in replacing beta cells, said Riccordi, is the potential of causing dangerously low blood sugar levels. Both beta and alpha cells are destroyed in people with type 1 diabetes, and alpha cells produce glucagon, a hormone that increases blood sugar levels in the body when they drop too low. So, if researchers only replace insulin-producing beta cells, and not alpha cells, there is a potential of causing low blood sugar levels, which can also be deadly.

Still, "it is important to explore all avenues in diabetes research," Riccordi said, "because what you learn in one area may be helpful for others. But don't place too much hope or hype in one area."

More information

Learn more about type 1 diabetes from the American Diabetes Association.

SOURCES: G. Ian Gallicano, Ph.D., associate professor, department of Biochemistry and Molecular and Cellular Biology, and director, Transgenic Core Facility, Georgetown University Medical Center, Washington, D.C.; Camillo Riccordi, M.D., scientific director, Diabetes Research Institute, Hollywood, Fla., Dec. 12, 2010, presentation, American Society of Cell Biology annual meeting, Philadelphia

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers Turn Stem Cells Into Intestinal Tissue in Lab
2. Stray Breast Tumor Cells in Early Chemo Could Be Bad Sign
3. Circulating tumor cells predicted recurrence, death in patients with early-stage breast cancer
4. Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
5. UCLA scientists discover mechanism that turns healthy cells into prostate cancer cells
6. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
7. Tumors bring their own support cells when forming metastases
8. Discovery halts breast cancer stem cells
9. Putting the squeeze on fat cells
10. Stanford researchers first to turn normal cells into 3-D cancers in tissue culture dishes
11. Spleen Cells Tied to Damage of Spinal Cord Injury in Animal Study
Post Your Comments:
Related Image:
Sperm-Producing Cells Coaxed to Produce Insulin
(Date:11/27/2015)... ... , ... According to an article published November 13th on, ... D.C. revolved around the fact that proper dental care, both at-home and in the ... between periodontal disease (more commonly referred to as gum disease) and diabetes. According to ...
(Date:11/27/2015)... ... ... According to an article published November 15th by ABC News, ... in light of the recent terrorist attacks in Paris, other cities are taking extra ... from reaching U.S. soil. Especially around special events that may be high-profile in nature, ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... A team ... ways to treat it. Surviving Mesothelioma has just posted the findings on the ... University Hospital Zurich analyzed the cases of 136 mesothelioma patients who were treated with ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When I ... an inventor from Hillside, N.J. "Many people catch diseases simply from sitting on ... will always be protected from germs." , He developed the patent-pending QUDRATECS to ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print ... USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation ... is distributed nationally, through a vast social media strategy and across a network ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
(Date:11/26/2015)... , November 26, 2015 ... addition of the "Radioimmunoassay Market by ... (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), ... Global Forecast to 2020" report to ... has announced the addition of the ...
Breaking Medicine Technology: