Navigation Links
Speedy Delivery of Clot-Busting Drug Helps Stroke Patients Avoid Disability

WEDNESDAY, Aug. 6, 2014 (HealthDay News) Another study confirms that "time is brain" when treating stroke patients with a powerful clot-busting drug, tPA.

Prompt treatment with tissue plasminogen activator (tPA, also known as alteplase) "is a very effective means of limiting the degree of disability in stroke patients," study co-author Dr. Jonathan Emberson, of University of Oxford in the U.K., said in a news release from the journal The Lancet.

The study, published in the journal on Aug. 5, also reinforces the idea that the quicker that patients can get tPA, the better.

One U.S. expert agreed. "The analysis reiterates the importance of patients going to the ER immediately at the time of developing acute neurological symptoms that could be due to a stroke," said Dr. Rafael Alexander Ortiz, director of interventional neuroradiology and stroke at Lenox Hill Hospital in New York City.

Clot-busting drugs are used to treat people who have suffered an ischemic stroke, which occurs when a clot blocks blood flow to the brain.

In the study, Emberson's team looked at data from more than 6,700 stroke patients who took part in nine clinical trials involving tPA.

The likelihood of a good outcome -- defined as no significant disability three to six months after stroke -- were 75 percent higher for patients who received the drug within three hours of initial stroke symptoms, compared with patients didn't get tPA.

While that three-hour window is ideal, even patients who got tPA a bit later received some benefit. For example, the chances of a good outcome were still 26 percent higher among patients who received the clot-buster within 4.5 hours of the attack, and 15 percent higher for those who received the drug more than four to five hours after initial stroke symptoms, the group found

The benefits of quick treatment with tPA were seen in all patient groups, including those older than 80 and those with severe strokes, the authors add.

There was a slight added risk with the drug, however: the researchers also found that tPA increased the risk of dying from brain bleeding by about 2 percent within the first few days after stroke.

One U.S. stroke expert called the new review "powerful."

"The information is very significant because it helps support our concept of 'time is brain' by showing that faster treatment times do result in better outcomes for patients," said Dr. Keith Siller, director of the Stroke Consultative Service at North Shore-LIJ's Cushing Neuroscience Unit in Manhasset, N.Y.

He said that the finding that tPA helped even elderly patients was key, because "there has been a negative bias about offering IV tPA because of concerns about decreased clinical benefit and increased hemorrhage in this subset of patients."

In the Lancet news release, study co-author Kennedy Lees, a professor of cerebrovascular medicine at the University of Glasgow, in Scotland, said that "what this shows is that we are up against the clock when treating ischemic stroke. Every minute counts. People need to be identified quickly and systems need to be in place to get them scanned, diagnosed accurately and then treated within minutes to hours."

More information

The American Heart Association/American Stroke Association has more about stroke treatments.

SOURCES: Rafael Alexander Ortiz, M.D. director, Neuro-Endovascular Surgery/Interventional Neuroradiology and Stroke, Lenox Hill Hospital, New York City; Keith A. Siller, M.D. director, Stroke Consultative Service, North Shore-LIJ's Cushing Neuroscience Institute, Manhasset, N.Y.; The Lancet, news release, Aug. 5, 2014


Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Low-Cost, Speedy Liver Test in Development
2. Speedy Claims Medical Billing Software Ready to Meet Challenge of New CMS 1500 Form
3. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
4. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
5. New delivery method improves efficacy of 2 common Parkinsons disease medications
6. Popularity Causing Several Week Lag In Delivery Of 'Plug In' Device To Start Saving On Electricity Between 8% and 20%
7. Internists express support for new payment and delivery models as basis for replacing SGR
8. Vaginal delivery as safe as cesarean for most early preterm births
9. Strategy developed to improve delivery of medicines to the brain
10. Elsevier launches new journal: Health Care: The Journal of Delivery Science and Innovation
11. Study finds unique anonymous delivery law effective in decreasing rates of neonaticide in Austria
Post Your Comments:
Related Image:
Speedy Delivery of Clot-Busting Drug Helps Stroke Patients Avoid Disability
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ... ... No.1 Herpes-only dating community in the world, revealed that over 50% of its members are ... people under the age of 50 – or 67% of the population - are infected ... HSV-1 infection . , "The data shocks us highly!" said Michelle Li, Co-Founder of ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping ... platform for mental health and wellness consultation, has collaborated with a leading web-based ... the knowledge gap experienced by parents and bring advice from parenting experts within ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... contact center software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term ... fully supported Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of ...
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent Applied Drug ... need to integrate dose form selection in early phase drug development. The first ... supporting and bringing together the UK’s emerging life sciences companies, corporate partners, and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Marker Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
(Date:11/25/2015)... 2015  The American Academy of Pediatrics (AAP), ... the March of Dimes cheered today,s signature into ... Act of 2015 (S.799), which takes much-needed ... exposed to drugs, such as opioids, and to ... three organizations have worked together leading advocacy efforts ...
(Date:11/25/2015)... 2015  ARKRAY USA , Inc., ... evidence demonstrating the accuracy of its blood glucose meter ... Resistance, Diabetes and Cardiovascular Disease in Los ... GLUCOCARD ® 01 meter and the Assure ® ... ability to accurately measure glucose levels in blood is ...
Breaking Medicine Technology: