Navigation Links
Spectrum Health study first to identify heart attack-causing plaque in living patients
Date:7/17/2013

GRAND RAPIDS, Mich., July 17, 2013 We may be closer to predicting who is at risk for a heart attack, according to a recently published Spectrum Health study.

Researchers with Spectrum Health's Frederik Meijer Heart & Vascular Institute used new imaging technology on patients being treated for heart attacks. The imaging technology allowed researchers to identify the characteristic makeup, or signature, of arterial plaque blocking an artery and causing a heart attack.

Knowing what type of plaque is present in narrowed arteries may help a physician determine a patient's risk for heart attacks and may lead to novel treatment options to avoid a serious cardiac event.

Previous research during autopsies has shown that most major heart attacks called ST-segment elevation myocardial infarctions (STEMIs) are caused by the rupture of lipid core plaque (LCP), a type of plaque rich in cholesterol. However, this is the first study to document the presence of LCP in living patients. The LCP was detected with the use of near-infrared spectroscopy (NIRS) performed with a special coronary catheter.

The study used this NIRS system to measure cholesterol in the plaques of 20 patients experiencing a STEMI. The measurements were made after blood flow was reestablished but before a stent was placed to keep the artery open.

The findings were published online this week in the Cardiovascular Interventions Journal of the American College of Cardiology.

"We have discovered a NIRS signature of the plaques which caused myocardial infarction, a leading cause of death and injury worldwide," said Ryan Madder, MD, a Spectrum Health interventional cardiologist and principal investigator of the study. "This signature is detectable at the time of cardiac catheterization using a novel intracoronary imaging device. It is our hope that this signature may be capable of predicting a myocardial infarction before it happens."

Madder says that these findings provide support for further research of arteries narrowed with LCP. He's interested in conducting a prediction study to determine if patients with significant deposits of LCP do have a higher risk of heart attack. "If using NIRS technology is validated as a reliable predictor of cardiac events, then randomized studies of promising systemic and local therapies could be conducted."

"Dr. Madder and the entire team at Spectrum Health have made a significant step forward in the effort to identify the cause of heart attacks in living patients," said James Muller, MD. Muller is chief medical officer of Infraredx, the company that developed the combined NIRS and ultrasound catheter. "It is likely that the signature of a heart attack identified in the Spectrum Health study is present long before the event and could therefore be identified before a dangerous heart attack has occurred. The Spectrum Health study will lead to large prospective studies of this possibility."

Muller has been active in the pursuit of vulnerable plaques for over 20 years, first as a member of the faculty of Harvard Medical School, and more recently in his role as chief medical officer of Infraredx. Madder used an imaging system developed by Infaredx, Inc., which uses advanced plaque characterization technology, NIRS, with intravascular ultrasound, for identification of plaque structure.

The system provides an image that displays key structural elements of a blockage. At the same time, the system performs spectroscopic analysis of optical data to produce a Chemogram map that indicates the location of LCP and quantifies the lipid core deposit in the artery.

Further research is needed, said Madder. "Through an international collaboration with several other centers, further studies are currently underway and others are being planned to validate this signature and to determine if near-infrared spectroscopy can accurately predict future myocardial infarction."


'/>"/>

Contact: Bruce Rossman
bruce.rossman@spectrumhealth.org
616-391-3706
Spectrum Health
Source:Eurekalert

Related medicine news :

1. Spectrum Surgical Offers Veterinary Bandage Scissor for Exotics and Avians
2. Spectrum Surgical Offers Pre-Configured Veterinary Dental Packs
3. Spectrum Surgical Attends Society of Gastroenterology Nurses and Associates' (SGNA) 40th Annual Conference in Austin, TX
4. Specialty Equipment Repair Services from Spectrum Surgical Instruments Corp.
5. Youths with autism spectrum disorder need help transitioning to adult health care
6. Can therapy dogs be beneficial for children with autism spectrum disorder?
7. UCI team finds new target for treating wide spectrum of cancers
8. Spectrum Surgical Announces Veterinary Eye Surgery Packs
9. Spectrum Surgical Releases Workstation-Mounted Surgical Instrument Inspection Magnifier for Inspecting Surgical Instruments
10. Spectrum Surgical Offers Surgical Instrument Identification Tape
11. Study details bullying involvement for adolescents with autism spectrum disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America proudly ... offer an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start and ... These 50,000 hour rated lamps utilize the existing electronic ballast, saving labor and ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Texas Cord Blood ... to the labor and delivery team at Women’s Hospital at Renaissance in Edinburg for ... birth at the hospital and decide to donate. , “Women’s Hospital at Renaissance ...
(Date:4/28/2017)... Ca (PRWEB) , ... April 28, 2017 , ... Bill ... management industry in the coastal communities. After Tina Howe joined the team, the Bill ... happy employees, honest services at affordable rates, and giving back to the San Diego ...
(Date:4/28/2017)... ... ... Intellitec Solutions announced the publication of a case study ... solution that integrates to their PointClickCare EHR software package. With the guidance of ... now has the capability to achieve its goal for a comprehensive EHR solution, ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular ... premier online modeling resource for fluorescence microscopists and optical system designers, enabling The ... 5 years spanning the globe, SearchLight has become a tremendously popular tool for ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), ... Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Executive Officer of the Company is scheduled to present on Tuesday, ... and the Chairman of the Board, Tony Holler ... ...
(Date:4/19/2017)... , April 19, 2017 Global Surgical Drainage ... are tubes used to remove excess liquid and air. ... pus, urine, bile or lymph. Surgical drains are used ... such as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery ... post-surgery to prevent accumulation of fluid e.g. blood or ...
(Date:4/19/2017)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... new treatments for cancer and other unmet medical ... announced underwritten public offering of 23,625,084 shares of ... of $2.00 per share, before deducting underwriting discounts ... Sorrento.  The net proceeds to Sorrento from this ...
Breaking Medicine Technology: