Navigation Links
Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
Date:4/22/2012

New research from Mount Sinai Medical Center in New York reveals that repeated exposure to cocaine decreases the activity of a protein necessary for normal functioning of the brain's reward system, thus enhancing the reward for cocaine use, which leads to addiction. Investigators were also able to block the ability of repeated cocaine exposure, to induce addiction. The findings, published online April 22 in the journal Nature Neuroscience, provide the first evidence of how cocaine changes the shape and size of neuron rewards in a mouse model.

Repeated exposure to cocaine decreases the expression of a protein necessary for normal functioning of the brain's reward system, thus enhancing the reward for cocaine use and stimulating addiction. Using the protein's light-activated form in real time, in a technique known as optogenetics, investigators were also able to block repeated cocaine exposure from enhancing the brain's reward center from cocaine. Even though the results are very early and many steps will be important in moving from mice to humans, the researchers say that the finding opens the door to a new direction for treatment for cocaine addiction.

"There are virtually no medication regimens for cocaine addiction, only psychotherapy, and some early work with vaccines," said the study's senior investigator, Eric Nestler, MD, PhD, Nash Family Professor of Neuroscience, Chairman of the Neuroscience and Director of the Friedman Brain Institute at Mount Sinai School of Medicine. The protein, Rac1, is found in many cells in mice, rats, monkeys, and humans, and it is known to be involved in controlling the growth of nerve cells.

Investigators "knocked out," or deleted, the gene responsible for Rac1 production, or injected a virus to enhance expression of Rac1.

"The research gives us new information on how cocaine affects the brain's reward center and how it could potentially be repaired," said Dr. Nestler. "This is th
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pollen.com Launches Features to Customize Allergy Information - Top Allergy Web Site Provides ZIP-specific Allergy Information and Diary to Track Symptoms
2. LifeScan Recalls Specific Lots of Consumer and Professional OneTouch(R) SureStep(R) Test Strips Due To Inaccurate Readings at High Levels
3. Latest quality and purity specifications for food ingredients help protect consumers
4. SCAN Health Plan Debuts the First Mobile Resource Center Built Specifically for Seniors
5. Specific lymph node radiotherapy is well tolerated after surgery in early breast cancer patients
6. Even 9-Month-Olds Choose Gender-Specific Toys
7. Study of Williams syndrome patients reveals specific genes role in intelligence
8. ASCO data show serum DNA blood tests detect cancers with high sensitivity and specificity
9. Study: Specific PTSD symptoms related to anger and aggressiveness among Iraq/Afghanistan veterans
10. Aging and longevity tied to specific brain region in mice
11. Study shows patient-specific vaccines for metastatic melanoma may induce durable complete regression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 The ... by companies whose management forgot – or ignored or ... value: Validate the market based on physician input before ... companies – more specifically, founders – become so enamored ... the key question: Will physicians use the device?” says ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 On February ... complaint in the United States District Court for the ... Financial Freedom, as well as insurance companies Balboa, QBE, ... 2015 in Case No. 3:14-cv-152.) , The Plaintiff, a ... insurance companies to force her to buy too much ...
(Date:3/3/2015)... Chicago, IL (PRWEB) March 03, 2015 ... sits down with CARE Surrogacy Center for ... The interview originally appearing online is an exhilarating revelation ... details that have led him from Australia to the ... a recent press interchange, Tolga Umar, CEO and Founder ...
(Date:3/3/2015)... Ca (PRWEB) March 03, 2015 Dan E. ... with a special focus on capital crimes, recently spoke on ... Sniper” murder trial. The hosts of the Independent Journal Review ... his history working first as a prosecutor and now as ... into the decisions made in the trial and sentencing of ...
(Date:3/3/2015)... The report “Alopecia – Pipeline Review, ... for Alopecia. Alopecia is the loss of hair. Alopecia ... of alopecia. Causes for alopecia include aging, genetics, illness, ... include male pattern hair loss, female diffuse hair loss, ... classified as focal or diffuse and by the presence ...
Breaking Medicine News(10 mins):Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 2Health News:Want to Succeed in Medical Technology? Don't Innovate in a Vacuum 3Health News:Borrower Accuses Mortgage Lenders of Racketeering in Forcing Insurance on Homeowners 2Health News:CARE Surrogacy Center Mexico Conducts Candid Interview with Australian Father of Twins 2Health News:CARE Surrogacy Center Mexico Conducts Candid Interview with Australian Father of Twins 3Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 2Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4
... the human brain has something to do with god, religion ... a study// of brains of people belonging to different religions. ... foreheads, helps us focus our attention in prayer and meditation. ... our skulls, is the seat of our sensory information. Newberg ...
... born with low birth weight worldwide, more than 95% of ... neonatal and infant mortality, poor growth and cognitive development, and ... diabetes and heart disease. ,In a new ... of Public Health (HSPH) and Muhimbili University College of Health ...
... newly discovered method of assembling organic molecules, a team ... to sidestep many of the expensive// and hazardous barriers ... ,The new approach allows scientists to synthesize molecules ... generate alternate versions of drug molecules that can damage ...
... effects of climate change in terms of unusual animal behavior, ... scientists at the University of Birmingham are trying out an ... they can be used to monitor the effects of climate ... diving deeper for food, that tells us something about the ...
... may protect their children from developing asthma later in life//. ... dietary intake by nearly 2,000 pregnant women and examined the ... than 1,200 of their children five years later. ... the pregnant women, the researchers found that the children of ...
... report high levels of stress and low social support ... system activity//, which can trigger inflammatory responses and put ... ,These inflammatory immune system responses involve increases in ... ,'Stress affects levels of serum cytokines across pregnancy,' ...
Cached Medicine News:Health News:Brain Structured to Make Human Beings Religious, Claims a US Scientist 2Health News:Multivitamins Improve Birth Outcomes Among Children Born With HIV 2Health News:New Chemistry Approach Promises Less Expensive Drugs 2Health News:New Chemistry Approach Promises Less Expensive Drugs 3Health News:New Chemistry Approach Promises Less Expensive Drugs 4Health News:Stress Increases Inflammation in Pregnancy, Putting Women at Risk 2
(Date:3/3/2015)... PARIS , March 3, 2015 ... enrolled 356 and 240 patients respectively Publications ... Journal of Clinical Gastroenterology highlight diagnostic value ... in China and across ... Mauna Kea Technologies (Euronext: MKEA, FR0010609263), inventor of Cellvizio®, ...
(Date:3/3/2015)... N.J. , March 3, 2015 Konica ... USA announced today a new, integrated portable ... portable solution is now available with a larger integrated ... console mounted system offers a larger viewing area to ... now provides additional space for accessories and storage, along ...
(Date:3/3/2015)... , March 3, 2015  Web Industries, Inc., ... services in the Medical Device, Advanced Composites, Consumer ... named a 3M Medical Specialties Preferred Converter by ... will allow companies to streamline their supply chains ... contact for 3M materials, intermediate converting services, and ...
Breaking Medicine Technology:Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 2Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 3Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 4Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 3Web Industries Receives 3M Preferred Converter Status 2
... 2011 Four hospitals serving Virginia patients reduced healthcare-acquired ... days, resulting in savings of $1.2 million in additional ... persistent action plan to existing federal hand washing protocols, ... fewer infections and reduced patient length-of-stay and unnecessary readmissions. ...
... Pharmaceuticals, Inc., a publicly held corporation, (Symbol: PDRX.PK) ... an electronic medical record, from Wilson Medical Software, ... quality, low-cost tool for physicians to maintain patient ... and assistants to rapidly record visit notes and ...
Cached Medicine Technology:Virginia Hospitals Reduce Infections 41% 2Virginia Hospitals Reduce Infections 41% 3PD-Rx Pharmaceuticals Acquires Wilson Medical's EMR 2
... Complete MoisturePlus is ... multi-purpose solution to offer ... essential electrolytes and taurine. ... protein, stores and conditions ...
Opti-Free Express multi-purpose disinfecting solution lasting comfort No Rub formula provides triple action protection for your contact lenses....
Light weight adjustable trial frame - Child...
Half Trial Frames with precision engineering and lightweight material....
Medicine Products: