Navigation Links
Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
Date:6/13/2008

Paris, France, Friday 13 June 2008: The TRAF1/C5 locus on chromosome 9 has been revealed to play a role in multiple autoimmune diseases including type 1 diabetes and systemic lupus erythematosus (SLE), according to new data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

TRAF1 (Tumour Necrosis Factor-receptor associated factor 1) and C5 (complement component 5) are both immune related genes thought to be closely involved in the onset and/or perpetuation of the inflammatory process. They sit adjacent to one another on chromosome 9 at location q33-34. The TRAF1/C5 gene has previously been established as a genetic risk factor for rheumatoid arthritis. In this study, a further link was also found between the gene locus and the presence of autoantibodies (antibodies against antigens naturally occurring in the human body commonly found in patients with immune disorders). Since many autoimmune disorders tend to coexist within a given family as well as an individual, this indicates that there may be a common genetic pathway something the researchers were keen to investigate.

In this study, genotyping of 735 type 1 diabetes patients and 746 SLE patients from Spain and The Netherlands identified a significant association of one part of the TRAF1/C5 gene with type 1 diabetes (odds ratio 1.14, p=0.027) and SLE (odds ratio 1.16, p=0.016). In order to test the reliability of this finding, researchers replicated the test in a homogeneous patient population originating from Crete, where an increase in the same part of the TRAF1/C5 gene was also observed when compared to respectively matched controls (odds ratio 1.64, p=0.002; odds ratio 1.43, p=0.002).

Lead researcher, Ms Fina Kurreeman of Leiden University Medical Center in The Netherlands, said, "The results of our study have shown that the TRAF/1C5 gene locus may have an important role in multiple autoimmune diseases. We hope that further study will give an insight into potential shared genetic pathways across autoimmune disorders and may even stimulate innovation into novel therapeutic targets in the future."

A further joint analysis of all type 1 diabetes (n=834)) and SLE patients (n=1018) patients yielded a common odds ratio of 1.19 (p=0.002) and 1.22 (p<0.001) respectively, indicating that this genetic risk factor has modest effect sizes in these diseases.


'/>"/>

Contact: Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. Specific antagonism lowers blood pressure
2. New technique detects specific chromosomal damage, may indicate lung cancer risk
3. Its a knock out: eIF4E-specific anti-sense oligonucleotides knock down cancer
4. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
5. Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms
6. Influenza: Insights into cell specificity of human vs. avian viruses
7. Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology
8. Sentillion Launches Channel Partner Program for Healthcare-Specific Identity & Access Management Solutions
9. Breast-Specific Gamma Imaging (BSGI) Changes Patient Care Management
10. Lung Cancer Alliance-Georgia Issues Second Annual State-Specific Report Card on Lung Cancer
11. Lung Cancer Alliance-Massachusetts Issues Inaugural State-Specific Report Card on Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... industry, announced today that Legacy Health is expanding its use of Intrigma’s cloud-based ... a highly successful initial proof of concept. The Portland, Oregon based health system ...
(Date:5/3/2016)... ... 03, 2016 , ... AvePoint, the Microsoft Cloud ... 6 Service Pack (SP) 7, the enterprise-class infrastructure management platform for SharePoint. ... of the platform’s latest features – whether in an on-premises, cloud, or hybrid ...
(Date:5/3/2016)... MD (PRWEB) , ... May 03, 2016 , ... ... line of reusable bags to replace billions of single-use, throw away plastic baggies. The ... devastating our oceans and sea life. , “The LunchSkins mission is all ...
(Date:5/2/2016)... FL (PRWEB) , ... May 03, 2016 , ... ... version of its FDA approved sSOIP telemedicine stethoscope software that enables the stethoscope ... version is called PCP-SSP and works with RNK’s flagship PCP-USB stethoscope. , Remote ...
(Date:5/2/2016)... ... May 02, 2016 , ... As directed by its ... Pennsylvania (HAP) issues its full support to allow certified nurse practitioners (CNP) to practice ... they have worked under such supervision for three years and 3,600 hours. , In ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... -- Pharmaceutical giant Johnson & Johnson has ... who says its talc-based powder products caused ovarian cancer. ... $5 million in compensatory damages and $50 million in ... ) , This is the second in ... the same court awarded $72 million to the family ...
(Date:5/3/2016)... Intec Pharma Ltd. (NASDAQ: ... today announced the appointment of Pnina Strauss-Levy ... "Ms. Strauss-Levy has 15 years of experience in clinical ... track record, having supported the advancement of several products ... the United States and ...
(Date:5/3/2016)... 2016 Norgine B.V. ... einen entscheidenden Meilenstein durch diese Veröffentlichung zur  ... Handeln, um Patientenresultate  bei Verdauungs- und Lebererkrankungen ... im Verständnis der Hepatischen Enzephalopathie bei und ... Hepatische Enzephalopathie in der Öffentlichkeit zu schaffen ...
Breaking Medicine Technology: