Navigation Links
Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
Date:6/13/2008

Paris, France, Friday 13 June 2008: The TRAF1/C5 locus on chromosome 9 has been revealed to play a role in multiple autoimmune diseases including type 1 diabetes and systemic lupus erythematosus (SLE), according to new data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

TRAF1 (Tumour Necrosis Factor-receptor associated factor 1) and C5 (complement component 5) are both immune related genes thought to be closely involved in the onset and/or perpetuation of the inflammatory process. They sit adjacent to one another on chromosome 9 at location q33-34. The TRAF1/C5 gene has previously been established as a genetic risk factor for rheumatoid arthritis. In this study, a further link was also found between the gene locus and the presence of autoantibodies (antibodies against antigens naturally occurring in the human body commonly found in patients with immune disorders). Since many autoimmune disorders tend to coexist within a given family as well as an individual, this indicates that there may be a common genetic pathway something the researchers were keen to investigate.

In this study, genotyping of 735 type 1 diabetes patients and 746 SLE patients from Spain and The Netherlands identified a significant association of one part of the TRAF1/C5 gene with type 1 diabetes (odds ratio 1.14, p=0.027) and SLE (odds ratio 1.16, p=0.016). In order to test the reliability of this finding, researchers replicated the test in a homogeneous patient population originating from Crete, where an increase in the same part of the TRAF1/C5 gene was also observed when compared to respectively matched controls (odds ratio 1.64, p=0.002; odds ratio 1.43, p=0.002).

Lead researcher, Ms Fina Kurreeman of Leiden University Medical Center in The Netherlands, said, "The results of our study have shown that the TRAF/1C5 gene locus may have an important role in multiple autoimmune diseases. We hope that f
'/>"/>

Contact: Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-077-892-70392
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific antagonism lowers blood pressure
2. New technique detects specific chromosomal damage, may indicate lung cancer risk
3. Its a knock out: eIF4E-specific anti-sense oligonucleotides knock down cancer
4. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements
5. Study Determines Breast-Specific Gamma Imaging Has Higher Specificity Than MRI in Patients With Equivocal Mammograms
6. Influenza: Insights into cell specificity of human vs. avian viruses
7. Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology
8. Sentillion Launches Channel Partner Program for Healthcare-Specific Identity & Access Management Solutions
9. Breast-Specific Gamma Imaging (BSGI) Changes Patient Care Management
10. Lung Cancer Alliance-Georgia Issues Second Annual State-Specific Report Card on Lung Cancer
11. Lung Cancer Alliance-Massachusetts Issues Inaugural State-Specific Report Card on Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 More ... annual President’s Circle Reception on Monday at the home ... accomplishments and hear from guest speaker Dr. Winifred Lender ... worlds. , Dr. Lender, a Santa Barbara psychologist, author ... challenges and benefits of living in the digital age. ...
(Date:10/25/2014)... 2014 The Wehrman Collaborative, ... IT-accessibility for disabled users by disabled users, has ... to Mackin Educational Resources of Burnsville, Minnesota, for ... and to the Minnesota Alliance for Patient Safety ... Medicine" website. Both organizations have met ...
(Date:10/25/2014)... 2014 Homeowners that are wondering how ... need wonder no more. Clean Crawls gives 5 ... out for when it comes to insulation in their ... article released by Clean Crawls, can cause problems throughout ... insulation that has deteriorated, become damp, or been infested ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 Limbkeepers® announced ... episode of Innovations with Ed Begley Jr, airing 1st ... TBA. , In this episode, Innovations will focus on ... to protect fragile, thinning skin on arms, hands, and ... learn about these versatile products, which help reduce injuries, ...
(Date:10/25/2014)... -- Not getting the right amount of sleep might ... suggests. Those who sleep less or more than ... be more prone to developing the chronic condition, which ... authors concluded that duration and quality of sleep are ... bowel diseases. "Both short and long durations of ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2
... 26 John Williams,a shrimp fisherman and executive ... the House Subcommittee on Oversight and,Investigations of the ... criticized the Food and Drug Administration,s,(FDA) reliance on ... legislative actions., "On behalf of the U.S. ...
... Customers and ... Private Insurance Corporations, OAKLAND, Calif., Feb. 26 ... organized by the California,Nurses Association/National Nurses Organizing Committee that ... a,9/11 rescue worker; Donna Smith, who has recently joined ...
... Settlement on Outstanding Disputes, SPOKANE, Wash., Feb. ... Sandpoint, Idaho reached settlement on four,outstanding disputes. The ... Spokane, Washington., "This settlement is very important ... capably despite management,s refusal to negotiate a fair,contract," ...
... entertains sports world, KANSAS CITY, Mo., Feb. ... with Kansas City roots. A team of college ... premier,community for all athletes, fans, coaches and professionals., ... have a positive impact,on the entire athletic community," ...
... ARJO, Inc. announces the release,of two new lifts, and ... a unique open, twin mast design, and the SARA ... Twin has twin masts, which improve stability and weight,distribution, ... design.,All powered functions, including Powered DPS (Dynamic Positioning System),are ...
... of the Board of Directors; Daniel ... Operating Officer -, EXTON, Pa., Feb. 26 ViroPharma Incorporated,(Nasdaq: ... J.,Milano will succeed Michel de Rosen as president and chief executive,officer ... directors. Mr.,de Rosen, who has led the company as president and ...
Cached Medicine News:Health News:Testimony to Congress Denounces FDA Reliance on Self-Policing 2Health News:Michael Moore Defends 9/11 Rescue Workers and Criticizes Insurance Industry on California Nurses Association Press Call 2Health News:Nurses Convince Hospital to Return to Bargaining Table 2Health News:AthletixNation.com Launches Sports Website and Community Programs 2Health News:Vincent J. Milano to Succeed Michel de Rosen as President and Chief Executive Officer of ViroPharma 2Health News:Vincent J. Milano to Succeed Michel de Rosen as President and Chief Executive Officer of ViroPharma 3
(Date:10/25/2014)... DUBLIN , Oct. 24, 2014 ... "Dental Equipment Market Current Trends, Opportunities - Global ... In this report, the global dental equipment ... geography. The dental systems and equipment market is expected ... equipment market during the forecast period (2014 to 2019). ...
(Date:10/25/2014)... , Oct. 24, 2014  America,s future engineers ... robotic competition at the  Medical Design and Manufacturing ... 29-30 th at the Minneapolis ... local student built robots from the "For Inspiration ... FIRST students and mentors will offer information to ...
(Date:10/25/2014)... , October 24, 2014 ... the addition of the "Global and Chinese ... their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ...
Breaking Medicine Technology:Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 2Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 3Local robotics teams compete - a "FIRST" at next week's MD&M Minneapolis- October 29-30th at the Minneapolis Convention Center 2Local robotics teams compete - a "FIRST" at next week's MD&M Minneapolis- October 29-30th at the Minneapolis Convention Center 3Global and Chinese Hemodialysis Concentrates Industry Report 2014 2Global and Chinese Hemodialysis Concentrates Industry Report 2014 3
... Quark siRNAs Examined Alone and in Combination ... Quark Pharmaceuticals, Inc., a,development-stage pharmaceutical company ... today announced that the,journal Cancer Research published ... target gene against non-small cell lung cancer ...
... Prophylaxis Treatment with Kogenate FS Reduces the,Risk of ... No Pre-Existing,Joint Damage, BERKELEY, Calif., Oct. 10 ... Food and Drug Administration (FDA) has,approved routine prophylaxis ... frequency of bleeding episodes and the risk of,joint ...
Cached Medicine Technology:Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 2Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 3Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 2FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 3FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 5
Synchron CX3 Delta is a critical care clinical system, providing unparalleled testing speed for the most frequently ordered chemistries-Glucose, BUN, Creatinine, Sodium, Potassium Chloride, CO2 Calci...
Iron (Total/Ferene). Storage temp: 15 - 30 C. Linearity: 0 - 500 ug/dl. Expected values: from males 60 - 160 ug/dl, from females 43 - 140 ug/dl. Available with Calibrator and Number of test are 120....
For the quantitative determination of iron, total iron-binding capacity in human serum....
HDL Cholesterol, liquid....
Medicine Products: