Navigation Links
Specialized Adult Stem Cells Re-Grow Fingertips
Date:8/24/2011

WEDNESDAY, Aug. 24 (HealthDay News) -- Specialized adult stem cells are make it possible for mammals to re-grow the tips of injured fingers or toes, rather than a "jack of all trades" cell type formed in response to serious injury, a new study shows.

Researchers from Stanford University found the regenerating stem cells are tissue-specific, meaning each has a particular job regenerating bone, skin, tendon, vessels or nerves.

The findings call into question a popular theory that damaged extremities are regenerated by a bump of cells considered "pluripotent," meaning that they are able to grow into a variety of cell types. This versatile bump of repair cells is called a blastema, but it appears to have nothing to do with fingertip regeneration.

"We've shown conclusively that what was thought to be a blastema is instead simply resident stem cells that are already committed to become specific tissue types," said Dr. Irving Weissman, director of Stanford's Institute for Stem Cell Biology and Regenerative Medicine in a news release. "The controversy about limb regeneration in mammals should be over."

Mice and some humans have the ability to re-grow the tips of injured fingers or toes. To better understand how they do this, Stanford researchers labeled specific tissue types of mice with fluorescent colors before cutting off a small part of the mice's toes. Over the course of three months, they examined the regenerated tissue.

The researchers found that each tissue type -- such as that found in nail, bone, tendon or blood vessels -- could only give rise to that type of tissue, Weissman said. "There was no cross-contribution between tissue types or germ layers," he said.

"I was extremely surprised," confessed first author Yuval Rinkevich. "I began the experiment very eager to find something like...one tissue type becoming another. But this is clearly not the case."

He and the other researchers noted, however, the findings could help develop ways to enhance regeneration in humans.

"Here we are characterizing and learning about a naturally occurring regeneration phenomenon without adding other genes," said Rinkevich. "We want to first understand how normal tissue regeneration works. Then we can try to exploit that knowledge to perhaps enhance the growth of digits or limbs in humans."

The researchers pointed out they also dismissed the alternate theory that stem cells circulating in the blood could play a role in this type of regeneration.

The study, published in the Aug. 24 issue of Nature, did not discredit previous studies showing that it is possible to persuade specialized adult cells to turn into cells very similar to embryonic skin cells.

More information

The National Institutes of Health provides more information on stem cell research.

-- Mary Elizabeth Dallas

SOURCE: Stanford University School of Medicine, news release, Aug. 24, 2011.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Specialized regulatory T cell stifles antibody production centers
2. Specialized blood plasma treatment does not improve rotator cuff healing, study finds
3. Clinical waste management needs specialized regulation
4. The Walden Group, a Specialized Strategic Healthcare Investment Banking Firm, Adds Key Advisory Services
5. Serving the World With Specialized Insurance for Missionaries
6. Racial disparities diminish in specialized cancer centers
7. Chateau Amber Retreat Provides Specialized Post-Cosmetic Surgery Care in Palm Springs Luxury
8. CareTech Solutions Presents Specialized Healthcare Call Center at HIMSS10
9. Short on specialized intensive care physicians, team-based approach improves ICU outcomes
10. Kellogg researcher helping eye care providers better assess driving in older adults
11. Study Shows Key Ways Young Adults Can Find, Keep a Job
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Specialized Adult Stem Cells Re-Grow Fingertips
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: