Navigation Links
Special sugar, nanoparticles combine to detect cholera toxin
Date:1/18/2011

A complex sugar may someday become one of the most effective weapons to stop the spread of cholera, a disease that has claimed thousands of lives in Haiti since the devastating earthquake last year.

A technique developed by University of Central Florida scientists would allow relief workers to test water sources that could be contaminated with the cholera toxin. In the test, the sugar dextran is coated onto iron oxide nanoparticles and then added to a sample of the water. If the cholera toxin is present, the toxin will bind to the nanoparticles' dextran. This is because dextran looks similar to the cholera toxin receptor (GM1) found on cells' surface in the victim's gut.

The technique likely would be less expensive than those currently available, and it would provide results more quickly, enabling workers to restrict access to contaminated sources and limit the spread of the disease.

"It's really quite amazing," said UCF assistant professor J. Manuel Perez, the lead researcher on the project. "It means we have a quicker diagnostic tool using a simple and relatively cheap sugar-nanoparticle combination."

Early studies also show that the technique could someday be used to treat someone infected with cholera, which is caused by poor sanitation and dirty water, and potentially other diseases, Perez said.

More studies are needed to prove the adaptability of the technique, but its impact could be huge. In countries with poor sanitation, outbreaks caused by drinking contaminated water often prove fatal. Deadly toxins also can result from bioterrorism or food contamination.

There are an estimated 3 million to 5 million cholera cases, and 100,000 to 120,000 deaths, worldwide each year, according to the World Health Organization. A cholera outbreak has killed more than 3,000 people in Haiti since the earthquake, and WHO warned earlier in January that the outbreak has not yet reached its peak.

Research findings appear online today in the journal Bioconjugate Chemistry. (http://pubs.acs.org/doi/abs/10.1021/bc100442q). The National Institute of General Medical Sciences at the National Institutes of Health funded the research.

The findings may give the Federal Drug Administration, Centers for Disease Control and Prevention and several other agencies additional screening tools to combat toxins. The UCF-developed technique is faster than current detection methods, and it would likely be less expensive because these nanoparticles are cheap to make in large quantities. The detection instruments are compact in some cases the size of a desktop computer and a handheld calculator, and they could be turned into mobile devices that relief workers or food screeners could use in the field.

"As we have seen in the 2010 outbreak in Haiti, cholera remains a serious threat," said Janna Wehrle, Ph.D., of the National Institutes of Health, who oversees Dr. Perez's and other grants that focus on protein structures and interactions. "By developing a fast and sensitive test for cholera toxin that does not require sophisticated equipment or refrigeration, Drs. Perez and Teter have provided health care workers with a potentially valuable tool for use in areas struck by natural disasters or with inadequate infrastructure. The possibility that the novel chemistry discovered by these investigators might also be useful for treating cholera is especially exciting."

Studies that are under way may confirm early indications that dextran can be an effective drug for patients infected with cholera, added UCF Associate Professor Kenneth Teter, a co-author on the study. This could be especially beneficial in developing countries such as Haiti, as dextran is a relatively inexpensive compound to produce.

Additionally, both dextran and iron oxide are commonly used in other medical applications. Dextran is often used to prevent blood clots anticoagulant and in emergency treatments of hemorrhagic and traumatic shock. Iron oxide nanoparticles are used to treat anemia and as MRI contrast agents to achieve improved anatomical imaging.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related medicine news :

1. Biological Psychiatry special issue: Postmortem research
2. Clinical waste management needs specialized regulation
3. fMRI special section of Perspectives on Psychological Science
4. Special Infant Formula Might Help Shield Babies from Type 1 Diabetes
5. Special skin keeps fish species alive on land
6. Hospital for Special Surgery scientists share advances in lupus and related conditions
7. Aging Pets Need Special Care: Expert
8. Womens unique connection to nature is explored in special issue of Ecopsychology
9. Telementoring may address need for surgical subspecialty expertise in remote locations
10. OncologyPRO: Unique portal for cancer specialists
11. Parkinsons disease: Excess of special protein identified as key to symptoms and possible new target for treatment with widely used anti-cancer drug imatinib
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Special sugar, nanoparticles combine to detect cholera toxin
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. Josh Olson, ... and Chandler, Arizona. , Dr. Olson says the decision to support the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
Breaking Medicine Technology: