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Special focus issue on sepsis
Date:1/7/2014

ndrial dysfunction in sepsis-induced multi-organ failure (Mervyn Singer), pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock (Daniel De Backer), an alternate pathophysiologic paradigm of sepsis and septic shockimplications for optimizing antimicrobial therapy (Anand Kumar), meningococcal disease and the complement system (Lisa Lewis and Sanjay Ram), contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis (Shiranee Sriskandan), the complex link between influenza and severe sepsis (Diana Florescu), animal models of sepsis (Mitchell Fink), invasive candidiasis as a cause of sepsis (Thierry Calandra), neonatal sepsis (James Padbury), pediatric sepsis (Adrienne Randolph), clinical controversies in the management of patients with severe sepsis (Simon Finfer), clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock (Aurora Pop-Vicas), bacterial toxins in sepsis (Girish Ramachandran), anti-endotoxin vaccines (Alan Cross), bacteriophage therapy (Xavier Wittebole), rapid diagnosis of sepsis (Konrad Reinhart), and severe sepsis and septic shockmanagement and performance improvement (Christa Schorr).

In an accompanying editorial, Dr. Opal highlights the importance of this collection of review articles, providing a detailed summary of the current knowledge and science of septic shock research, extending from the molecular to the population level. He writes, "Septic shock continues to pose formidable challenges for emergency room physicians, critical care specialists, surgeons, and infectious disease clinicians alike in caring for these critically ill patients. Early recognition of sepsis and improved therapies to manage the multi-organ dysfunction that frequently follows sepsis pathophysiology remain major unmet medical needs."


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Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

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