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Special focus issue on sepsis
Date:1/7/2014

A special issue on sepsis has been released by the publisher Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Virulence have been authored by world-class investigators and provide new insights into both the pathogen-related factors and the host defense mechanisms that lead to septic shock and contribute to its resolution or fatal outcome.

Sepsis, or septic shock, is an excessive inflammatory response in answer to a serious infection, most commonly by bacteria, but also fungi, viruses, and parasites. Different microbial components, such as bacterial lipopolysaccharide (LPS), endotoxins, or exotoxins can cause the typical septic inflammatory cascade. The condition can continue even after the infection that caused it is gone. It is a significant cause of morbidity and mortality worldwide. Characteristics of sepsis are massive release of proinflammatory cytokines resulting in tissue damage, an uncontrolled reduction in blood-pressure, multiple organ failure, and death. Sepsis can originate anywhere microbes can gain entry to the body, common sites including the genitourinary tract, the liver and its bile ducts, the gastrointestinal tract, and the lungs. The condition is often life-threatening, especially in people with a weakened immune system or other medical issues.

Dr. Steven Opal from Alpert Medical School of Brown University (Pawtucket, RI USA) has worked with the editorial team of Virulence to organize this special issue on sepsis. Over 20 papers in this issue discuss many different aspects of sepsis and septic shock, such as epidemiology of severe sepsis (Sachin Yende), gender differences in sepsis (Irshad Chaudry), systemic inflammatory response syndrome (Robert Balk), the PIRO model (John Marshall), host innate immune responses to sepsis (Willem Joost Wieringa), the changing immune system in sepsis (Jonathan Boomer), pathogenesis of bacteremia (Eirini Christaki), role of mitocho
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Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience
Source:Eurekalert

Page: 1 2

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