Navigation Links
Spanish scientists confirm extra virgin olive oil helps to combat breast cancer
Date:2/5/2009

This release is available in Spanish.

Researchers of the Catalonian Institute of Oncology (Spain) and the University of Granada (Spain) have discovered that extra virgin olive oil may help to combat breast cancer, according to a paper published in the last issue of the renowned scientific journal BMC Cancer. The scientists have confirmed the bioactivity of polyphenols (this is, natural antioxidants) present in olive oil in breast cancer cell lines.

The study has proved the anti-HER2 effect of fractions of phenolic compounds directly extracted of extra virgin olive oil in breast cancer cell lines. They have used solid-phase extraction methods of semi-preparative liquid chromatography to isolate fractions of commercial oils and, later, separation techniques (capillary electrophoresis and liquid chromatography connected to mass spectrometry) to check the purity and composition of the fractions.

Such fractions were tested in their anti-cancer capacity both against positive HER2 and negative HER2 breast cancers, using in Vitro models and evaluating the effect of polyphenolic fractions in the expression and activation of HER2 oncoprotein through ELISA specific methods for HER2. Fractions containing polyphonels such as hydroxitirosol, tirosol, elenolic acid, lignans, pinoresinol and acetopinoresinol, and secoiridoids, diacetox oleuropein aglycone, ligustrosid aglycone and oleuropein aglycone were able to induce important tumoricid effects in a range of micromolar and in a selective way against HER2 oncogene.

Proved potentiality

Therefore, this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation. Such results, together with the fact that humans have consumed secoiridoids and lignans safely for a long time through oil and olive oil consumption, endorse the fact that such phytochemicals could be an excellent and safe basis for the design of new antiHER2 compounds.

This work has been carried out by Javier A. Menndez, coordinator of the Translational Research Unit of the Catalonian Institute of Oncology (ICO) in Girona, and by doctors Alberto Fernndez Gutirrez in charge of the "Research Group of Analytic, Environmental, Biochemical and Food Control"- and Antonio Segura Carretero, member of such group.

This Research Group of the Department of Analytical Chemistry of the University of Granada (Spain) has developed other interesting research works in the characterization of polyphenolic profiles of an important number of plants and metabolomic studies of extracts with proved bioactivity through the use of advanced separation techniques.


'/>"/>

Contact: Alberto Fernandez Gutierrez
albertof@ugr.es
34-958-243-296
Universidad de Granada
Source:Eurekalert

Related medicine news :

1. Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations
2. Command Spanish Online offers Healthcare Spanish Anytime, Anywhere, and at Your Own Pace
3. Nurses: Command Spanish Onlines Occupational Spanish Language Course Accepted for Credit by the American Nurses Credentialing Center (ANCC)
4. Elsevier to Include Doyma Spanish Medical Collection Titles on ScienceDirect
5. Folic acid survey of Spanish-speaking women finds most are missing benefits, March of Dimes says
6. First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says
7. Guide on Blood Thinner Now Available in Spanish
8. Newport Introduces More Resources for Spanish Speaking Plan Participants
9. Leading Spanish Health Service Provider Selects Autonomy for Innovation in Healthcare
10. Yo Mujer: Woman Escapes from Abusive Marriage in New Spanish-Language Novel
11. Response rates to antidepressants differ among English- and Spanish-speaking Hispanics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... ... it will join America's leading engineers at the American Society of Safety Engineers ... World Congress Center. , Engineers, speakers and exhibitors from more than 40 ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... its inaugural health care blockchain event, Distributed: Health, to be held in Nashville, ... downtown Symphony Center. , A 24-hour Hackathon preceding the event will host teams ...
(Date:5/24/2016)... ... May 24, 2016 , ... i2i, a national leader in ... its “Transforming Outcomes” User Conference in Las Vegas on May 19-20, 2016. ... set the market standard for meaningful population health management. The company recently ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... Center at Sentara Northern Virginia Medical Center located in Woodbridge, VA. The ... surgical services into a single site. , The new 2 story building houses ...
(Date:5/24/2016)... Irvine, CA — , ... ... the appointment of three new members of its Advisory Board. ... Chico and Sarah Kusch. “All three of them embody the mission ... team. We are very fortunate to have them as we continue ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 ReportsnReports.com adds "Chronic ... that provides an overview on therapeutic pipeline of ... stages, therapeutics assessment by drug target, mechanism of ... type, along with latest updates, and featured news ... involved in the therapeutic development for Chronic Cough ...
(Date:5/24/2016)... HENDERSON, Nev. , May 24, 2016  Diana ... painfully "eats" her organs from the inside out.  This ... her completely dependent on her children and grandchildren to ... of her wheelchair, Diana,s family cannot haul the wheelchair.  ... rides in the car, and Diana is left to ...
(Date:5/24/2016)... , May 24, 2016 ... the world , s first dual ... fistula intervention   OrbusNeich, a global company ... expanded its portfolio to include products to treat peripheral ... the company,s first entry devices for lower limb and ...
Breaking Medicine Technology: