Navigation Links
Spanish scientists confirm extra virgin olive oil helps to combat breast cancer

This release is available in Spanish.

Researchers of the Catalonian Institute of Oncology (Spain) and the University of Granada (Spain) have discovered that extra virgin olive oil may help to combat breast cancer, according to a paper published in the last issue of the renowned scientific journal BMC Cancer. The scientists have confirmed the bioactivity of polyphenols (this is, natural antioxidants) present in olive oil in breast cancer cell lines.

The study has proved the anti-HER2 effect of fractions of phenolic compounds directly extracted of extra virgin olive oil in breast cancer cell lines. They have used solid-phase extraction methods of semi-preparative liquid chromatography to isolate fractions of commercial oils and, later, separation techniques (capillary electrophoresis and liquid chromatography connected to mass spectrometry) to check the purity and composition of the fractions.

Such fractions were tested in their anti-cancer capacity both against positive HER2 and negative HER2 breast cancers, using in Vitro models and evaluating the effect of polyphenolic fractions in the expression and activation of HER2 oncoprotein through ELISA specific methods for HER2. Fractions containing polyphonels such as hydroxitirosol, tirosol, elenolic acid, lignans, pinoresinol and acetopinoresinol, and secoiridoids, diacetox oleuropein aglycone, ligustrosid aglycone and oleuropein aglycone were able to induce important tumoricid effects in a range of micromolar and in a selective way against HER2 oncogene.

Proved potentiality

Therefore, this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation. Such results, together with the fact that humans have consumed secoiridoids and lignans safely for a long time through oil and olive oil consumption, endorse the fact that such phytochemicals could be an excellent and safe basis for the design of new antiHER2 compounds.

This work has been carried out by Javier A. Menndez, coordinator of the Translational Research Unit of the Catalonian Institute of Oncology (ICO) in Girona, and by doctors Alberto Fernndez Gutirrez in charge of the "Research Group of Analytic, Environmental, Biochemical and Food Control"- and Antonio Segura Carretero, member of such group.

This Research Group of the Department of Analytical Chemistry of the University of Granada (Spain) has developed other interesting research works in the characterization of polyphenolic profiles of an important number of plants and metabolomic studies of extracts with proved bioactivity through the use of advanced separation techniques.


Contact: Alberto Fernandez Gutierrez
Universidad de Granada

Related medicine news :

1. Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations
2. Command Spanish Online offers Healthcare Spanish Anytime, Anywhere, and at Your Own Pace
3. Nurses: Command Spanish Onlines Occupational Spanish Language Course Accepted for Credit by the American Nurses Credentialing Center (ANCC)
4. Elsevier to Include Doyma Spanish Medical Collection Titles on ScienceDirect
5. Folic acid survey of Spanish-speaking women finds most are missing benefits, March of Dimes says
6. First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says
7. Guide on Blood Thinner Now Available in Spanish
8. Newport Introduces More Resources for Spanish Speaking Plan Participants
9. Leading Spanish Health Service Provider Selects Autonomy for Innovation in Healthcare
10. Yo Mujer: Woman Escapes from Abusive Marriage in New Spanish-Language Novel
11. Response rates to antidepressants differ among English- and Spanish-speaking Hispanics
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... Sir ... customer service: the TrustDale certification. The award recognizes good companies for excellence in ... , tile and grout, and hard surface restoration company earned this recognition after ...
(Date:11/24/2015)... ... 2015 , ... Autism Speaks, the world’s leading autism science and advocacy organization, ... the generosity of people around the world. On December 1, supporters can make an ... and share the personal stories behind those gifts. , Just as Black Friday ...
(Date:11/24/2015)... ... ... Don Peck’s mother wondered if she was a descendant of Samuel Fuller, a passenger on ... search for information, Don and his aunt discovered that she was not, in fact, related ... was Don’s father who was descended from not one, but four passengers on the famed ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dehydration, defined as a loss ... to perspiration in the hot sun, and heat stroke and death will quickly follow. ... radio host Sharon Kleyne. Every cell, system and structure requires water to function properly. ...
(Date:11/24/2015)... ... November 24, 2015 , ... The ... OSHA Training Institute Education Center in Northern California, is calling on retail employers ... sales events. As the volume of sales and shoppers rapidly expands, retailers ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , November 24, 2015 F1000Workspace ... for scientists - since it was launched just six months ... reference management and authoring platform for scientists - since it ... million references have been loaded on to F1000Workspace ... scientists - since it was launched just six months ago. ...
(Date:11/24/2015)... 24, 2015  Family Rentals, a South ... launch of their newly designed, mobile-responsive website. ... --> Logo - ... --> Now, renting essential items for ... just got a whole lot easier through the ...
(Date:11/24/2015)... NEWTOWN, Pa. , Nov. 24, 2015  NuShield, Inc., an industry leader in LCD screen ... mobile and stationary computer technology as part of their patient monitoring or electronic documentation system. ... ... ... ...
Breaking Medicine Technology: