Navigation Links
Spanish gene expression data promise targeting of anti-angiogenesis treatment
Date:4/29/2010

Analyzing the expression of particular genes in lung cancers could soon allow researchers to identify groups of patients who are likely to benefit most from treatment with angiogenesis-inhibitor drugs, a Spanish team reports.

Dr Eloisa Jantus from the General University Hospital of Valencia reports new findings from an analysis of 135 lung cancer specimens. She and her colleagues, led by Dr Carlos Camps, evaluated the expression of 8 different genes related to vascular endothelial growth factor (VEGF), a molecule that helps tumors develop the blood supply they need to grow larger. VEGF is a key target for new "anti-angiogenesis" drugs that aim to arrest this process.

"The vascular endothelial growth factor (VEGF) family of ligands and receptors has an important role in tumor angiogenesis," Dr Jantus said. "We studied the expression, at molecular level, of the members of this family in tumor samples as well as in normal lung tissues in order to understand their role in tumor development and prognosis."

The group measured the expression of the 8 genes, including VEGF A, -B, -C and PIGF, tyrosine-kinase receptors VEGFR-1, VEGFR-2 and VEGFR-3. In addition to these receptors, they also studied related genes for neuropilins NRP1 and NRP2.

The researchers then correlated gene expression levels with important clinical outcomes, including overall survival and the time to tumor progression, in patients whose tumors were surgically removed.

"Patients whose tumors expressed high levels of VEGF-A and VEGFR-1 tended to have a worse prognosis in terms of progression-free survival and overall survival," Dr Jantus said. "The subgroup of patients with high levels of expression of VEGF-A and VEGFR-1 showed a 30% shorter time to progression and overall survival, when compared to those with low expression levels."

The findings provide early clues that 'angiogenic profiles' could define subgroups of patients who will better benefit from the use of anti-angiogenic therapies, the researchers say.

"We think that it seems improbable that a single angiogenic marker will provide all of the relevant clinical information because only one biomarker cannot reflect the complexity of the angiogenic process; however, when the markers were considered in combination, they provided a more comprehensive pattern or profile, significantly improving their prognostic value."

These angiogenic profiles need validation in larger groups of patients before they can be implemented in the clinic, the researchers note, however they represent an emerging way to improve lung cancer therapy by tailoring it to the characteristics of individual patients and their tumors.


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. LifeLinks Revolutionizes Video Interpreting, Shows Spanish Interpreting in Added Dimension-VIDEO!
2. Prescriptions Translated to Spanish Could Be Hazardous to Health
3. HealthLinkRx Announces Classes in Spanish for Occupational and Physical Therapists
4. Yakult USA Launches Spanish-Language Website
5. Put Some Fiesta Into Dinner - Sam's Club Adds New Spanish Red Wine From Torres Winery
6. ECELA Spanish School in Argentina Offers Students Opportunity to Work in Buenos Aires Free Health Fair
7. Spanish Only, Please: Special Latino Clinic Launched For Potential Abdominal Transplant Patients
8. Spanish-Speaking Mothers Less Likely to Turn on TV
9. Really Big Coloring Books Debuts Bi-Lingual Spanish-English Line of Custom and Imprintable Coloring Books
10. Gene expression test reduces need for invasive heart muscle biopsy
11. Personal Tragedy Reveals Untapped Artistic Expression / Family Business Memorializes Loved Ones with Compassion During Grieving
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... ... May 19, 2017 , ... In a continuous effort to raise awareness of ... mattress company that specializes in natural and organic latex mattresses, has announced that they ... every unique share their recent viral Facebook video receives, up to $10,000.00. ...
(Date:5/19/2017)... Kansas City, Mo (PRWEB) , ... May 19, 2017 , ... ... on Saturday, May 20, his name will already appear on two major research studies ... Busch has been working with Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Miller Agency, a Jacksonville ... and business owners in the region, is embarking on a cooperative charity event ... families. , Multiple sclerosis (MS) is a demyelinating disease that affects the insulation ...
(Date:5/19/2017)... ... May 19, 2017 , ... As a groundbreaking surgeon on the frontline of ... cancer screenings. Early detection of the disease, he says, can make a world of ... Urology , stands alongside the Georgia Comprehensive Cancer Control’s (GC3) Prostate Cancer Task Force ...
(Date:5/19/2017)... ... May 18, 2017 , ... Eisenhower ... served eight American presidents of both political parties, will become the 9th Chairman ... Colin L. Powell, USA (Retired) as Chairman in May, 2018. , Secretary Gates ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... , May 22, 2017  As the specialty ... whole continue to make the revolutionary shift from ... important for ensuring positive patient outcomes and shaping ... are shifting focus away from clinical trials and ... of long-term specialty drug therapy utilization in precise ...
(Date:5/15/2017)... , May 15, 2017 Enterin Inc., a ... and developing novel compounds to treat Parkinson,s disease (PD), ... study is a Phase 1/2a randomized, controlled, multicenter study involving ... It will enroll 50 patients over a 9-to-12-month period. The ... in 10 patients with PD. Participating sites include ...
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
Breaking Medicine Technology: